Withers, Dominic J.

Inhibition of Food Intake in Obese Subjects by Peptide YY 3–36

Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,604

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 1,120

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 953

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

Cited by 822

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 788

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

Cited by 532

Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

Foukas, L. C., Claret, M., Pearce, W., Okkenhaug, K., Meek, S., Peskett, E., Sancho, S., Smith, A. J. H., Withers, D. J., & Vanhaesebroeck, B. (2006) · Nature

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 463

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 398

Cardiac glycosides are broad-spectrum senolytics

Guerrero, A., Herranz, N., Sun, B., Wagner, V., Gallage, S., Guiho, R., Wolter, K., Pombo, J., Irvine, E. E., Innes, A. J., et al. (2019) · Nature Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 359

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.

Kulkarni, R. N., Wang, Z. L., Wang, R. M., Hurley, J. D., Smith, D. M., Ghatei, M. A., Withers, D. J., Gardiner, J. V., Bailey, C. J., & Bloom, S. R. (1997) · Journal of Clinical Investigation

Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Cited by 296

Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo

Previs, S. F., Withers, D. J., Ren, J.-M., White, M. F., & Shulman, G. I. (2000) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 291

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Widjaja, A. A., Lim, W.-W., Viswanathan, S., Chothani, S., Corden, B., Dasan, C. M., Goh, J. W. T., Lim, R., Singh, B. K., Tan, J., et al. (2024) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 238

Galactose‐modified duocarmycin prodrugs as senolytics

Guerrero, A., Guiho, R., Herranz, N., Uren, A., Withers, D. J., Martínez‐Barbera, J. P., Tietze, L. F., & Gil, J. (2020) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 172

Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice

Cantley, J., Selman, C., Shukla, D., Abramov, A. Y., Forstreuter, F., Esteban, M. A., Claret, M., Lingard, S. J., Clements, M., Harten, S. K., et al. (2008) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 127

The hypoxia response pathway and β ‐cell function

Cantley, J., Grey, S. T., Maxwell, P. H., & Withers, D. J. (2010) · Diabetes, Obesity and Metabolism

Pancreatic function and diabetesCancer, Hypoxia, and Metabolism

Cited by 119

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

Foukas, L. C., Bilanges, B., Bettedi, L., Pearce, W., Ali, K., Sancho, S., Withers, D. J., & Vanhaesebroeck, B. (2013) · EMBO Molecular Medicine

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 91

Detection of senescence using machine learning algorithms based on nuclear features

Duran, I., Pombo, J., Sun, B., Gallage, S., Kudo, H., McHugh, D., Bousset, L., Barragan Avila, J. E., Forlano, R., Manousou, P., et al. (2024) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 85

Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults

Van de Pette, M., Abbas, A., Feytout, A., McNamara, G., Bruno, L., To, W. K., Dimond, A., Sardini, A., Webster, Z., McGinty, J., et al. (2017) · Cell Reports

Genetic Syndromes and ImprintingEpigenetics and DNA Methylation

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Ribosomal S6 kinase 1 regulates ‘inflammaging’ via the senescence secretome

Gallage, S., Irvine, E. E., Pedroni, S. M. A., Barragan Avila, J. E., Khadayate, S., Pombo, J., Brookes, S., Heide, D., Dharmalingham, G., Choudhury, A. I., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 31