The DOI matches its Crossref record; 69 of the 71 references it cites were found in a registry or an index.
Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
Open accessAbstract
Background and aims: Diabetic kidney is more sensitive to ischemia/reperfusion (I/R) injury, which is associated with increased oxidative stress and impaired nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling. Melatonin, a hormone that is secreted with the rhythm of the light/dark cycle, has antioxidative effects in reducing acute kidney injury (AKI). However, the molecular mechanism of melatonin protection against kidney I/R injury in the state of diabetes is still unknown. In the present study, we hypothesized that melatonin attenuates renal I/R injury in diabetes by activating silent information regulator 2 associated protein 1 (SIRT1) expression and Nrf2/HO-1 signaling. Methods: Control or streptozotocin (STZ)-induced Type 1 diabetic rats were treated with or without melatonin for 4 weeks. Renal I/R injury was achieved by clamping both left and right renal pedicles for 30 min followed by reperfusion for 48 h. Results: Diabetic rats that were treated with melatonin undergoing I/R injury prevented renal injury from I/R, in aspects of the histopathological score, cell apoptosis, and oxidative stress in kidney, accompanied with decreased expressions of SIRT1, Nrf2, and HO-1 as compared with those in control rats. All these alterations were attenuated or prevented by melatonin treatment; but these beneficial effects of melatonin were abolished by selective inhibition of SIRT1 with EX527. Conclusion: These findings suggest melatonin could attenuate renal I/R injury in diabetes, possibly through improving SIRT1/Nrf2/HO-1 signaling.
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“In a recent animal study, it has been confirmed that melatonin was able to attenuate kidney ischemia/reperfusion by the triggering SIRT1/Nrf2/HO-1 signaling pathway (Shi et al. 2019).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Shi et al. 2019
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Cites
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Update on Mechanisms of Ischemic Acute Kidney Injury
Devarajan, P. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006010017 · Cited by 1,026
Melatonin: Pharmacology, Functions and Therapeutic Benefits
Tordjman, S., Sylvie Chokron, A., Delorme, R., Charrier, A., Bellissant, É., Jaafari, N., & Fougerou, C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666161228122115 · Cited by 879
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Bonkowski, M. S., & Sinclair, D. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.93 · Cited by 834
Melatonin: Buffering the Immune System
Carrillo‐Vico, A., Lardone, P. J., Álvarez‐Sánchez, N., Rodríguez-Rodríguez, A., & Guerrero, J. M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14048638 · Cited by 763
Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 680
Daitoku, H., Hatta, M., Matsuzaki, H., Aratani, S., Ohshima, T., Miyagishi, M., Nakajima, T., & Fukamizu, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400593101 · Cited by 616
Flagged first, then by citations
2 of the 71 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Bao, 2018, Kidney disease models: tools to identify mechanisms and potential therapeutic targets, Zool. Res., 39, 72
- Bai, 2016, Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1, Sci. Rep., 6, 32199, 10.1038/srep32199 · DOI
- Hadj, 2015, Melatonin modulates endoplasmic reticulum stress and Akt/GSK3-beta signaling pathway in a rat model of renal warm ischemia reperfusion, Anal. Cell Pathol. (Amst.), 2015, 635172
Cited by
Sorted by citations
Items 101–135 of 135
Song, R., Ren, J., Sun, J., & Li, M. (2021) · Archives of Biological Sciences · doi:10.2298/abs210111004s · Cited by 6
Heme oxygenase-1 as a predictor of sepsis-induced acute kidney injury: a cross-sectional study
Xia, S., Zhang, M., Liu, H., Dong, H., Wu, N., Wiedermann, C. J., Andaluz‐Ojeda, D., Chen, H., & Li, N. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-4793 · Cited by 6
Ferroptosis at the crossroads: Insights and advances in non-neoplastic pancreatic diseases
Gao, D., Chen, T., Dong, J., He, Y., Ge, N., Guo, J., Sun, S., & Yang, F. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114870 · Cited by 7
Ghafil, F. A., Majeed, S. A., Qassam, H. S., Mardan, H. W., & Hadi, N. R. (2023) · Wiadomości Lekarskie · doi:10.36740/wlek202301117 · Cited by 5
Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease
Chen, J., Zhang, S., Xue, X., Ma, X., Chen, A., Wu, Y., Wang, G., Zhang, Q., Xue, Y., Jia, Y., et al. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025034 · Cited by 4
Hosseinzadeh, A., Seirafianpour, F., Sheibani, M., Taheri, M., Naeini, A. J., Reiter, R. J., & Mehrzadi, S. (2025) · Current Drug Targets · doi:10.2174/0113894501360934250512052503 · Cited by 4
Tweij, T.-A. R., Al-Issa, M. A., Hamed, M., Khaleq, M. A. A., Jasim, A. H., & Hadi, N. R. (2022) · Wiadomości Lekarskie · doi:10.36740/wlek202212108 · Cited by 4
Effects of melatonin against acute kidney injury: A systematic review and meta-analysis
Yang, J., Gan, Y., Feng, X., Chen, X., Wang, S., & Gao, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110372 · Cited by 4
Liu, Y., Zhang, R., Zou, J., Yin, H., Zhao, M., & Zhao, L. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4078 · Cited by 6
ÖZENOĞLU, S., TURAN, İ., ÖZAÇMAK, H. S., & ÖZAÇMAK, V. H. (2020) · Turkish Journal of Diabetes and Obesity · doi:10.25048/tudod.595479 · Cited by 4
Saikosaponin-D Prevents Acute Renal Injury via Inhibition of NLRP3 Inflammasome By SIRT1
Lin, K., Yang, F., Zhang, X., Zhao, J., Liu, Y., Zhao, H., Hu, Z., Liu, B., & He, C. (2022) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-022-02554-w · Cited by 4
Effects of curcumin and melatonin treatment in the cerebral cortex of adult rats
Yazıcı-Mutlu, Ç., Aktan, A. K., & AKBULUT, K. G. (2023) · General Physiology and Biophysics · doi:10.4149/gpb_2022047 · Cited by 4
PROTECTIVE ROLE OF MELATONIN FOR ACUTE KIDNEY INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS
Jing, Y., Bao, X., & Meng, L. (2023) · Shock · doi:10.1097/shk.0000000000002278 · Cited by 6
Alsufyani, S. E., Eid, A. H., Althobaiti, M. M., El‐Sheikh, A. A. K., Arafa, E. A., Ashour, A. M., & Arab, H. H. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04736-5 · Cited by 3
Liu, X., Hou, M., Lv, X., Lan, W., Li, X., Han, X., Su, Q., Hu, J. Y., Zhang, Y., Liu, Y., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178864 · Cited by 3
The effect of melatonin on benzo(a)pyrene-induced renal toxicity in mice
Barangi, S., Asadi, R., Mehri, S., & Karimi, G. (2023) · Toxicology and Industrial Health · doi:10.1177/07482337231166491 · Cited by 3
Arab, H. H., Althobaiti, M. M., Alharthi, A. K. Z., Almalki, E. O., Alsoubie, S. S., Qattan, J. M., Almalki, S. A., Ashour, A. M., & Eid, A. H. (2024) · Pharmaceuticals · doi:10.3390/ph17121690 · Cited by 3
Yu, X., Li, C., Ming, R., Wang, B., Guo, H., & Li, B. (2025) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2025.104345 · Cited by 2
Fan, W., Huang, J., Guo, Z., Zhong, A., Tong, X., Li, X., Li, W., Chen, Y., Chen, Y., Lin, X., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178541 · Cited by 2
Gong, D.-J., Chen, X., Dong, Z., Chen, H., & Liu, Z. (2026) · Renal Failure · doi:10.1080/0886022x.2026.2652103 · Cited by 2
Yaşar, F. K., Çil, N., Önder, E., Avcı, E., Özlülerden, Y., & Mete, G. A. (2025) · International Journal of Urology · doi:10.1111/iju.70054 · Cited by 2
Gong, D.-J., Dong, Z., Chen, X., Chen, H., & Lin, H. (2024) · Acta Cirúrgica Brasileira · doi:10.1590/acb396124 · Cited by 1
Melatonin’s role in redox homeostasis: A preclinical and clinical perspective
Torres, F. F., Bernardo, V. S., Zucão, A. C. A., Gazarini, L., Reiter, R. J., & da Silva, D. G. H. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100147 · Cited by 2
Sapmaz, T., Topkaraoğlu, S., Şevgin, K., Tekayev, M., Guler, E. M., Kuraş, S., Aktaş, S., & İrkörücü, O. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152315 · Cited by 1
Li, N., Liu, X., Liu, W., Li, S., Lei, Y., & Wang, B. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102433 · Cited by 1
Topkaraoğlu, S., Sapmaz, T., Şevgin, K., Tekayev, M., Kuraş, S., Pence, H. H., Guler, E. M., Aktaş, S., & İrkörücü, O. (2026) · Biotechnic & Histochemistry · doi:10.1080/10520295.2026.2642383 · Cited by 1
Antioxidants and kidney diseases
Jorge, R. J. B., Marinho, A. D., Silveira, J. A. D. M., Ramos, M. M. V., Braga, J. R. M., Alves, R. D. S., Júnior, F. A. N., Vasconcelos, M. D. S., Sanches-Silva, A. T., Nabavi, S. M., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819096-8.00059-8 · Cited by 1
Al-Gholam, M. A.-S., Abd-Elhafiz, H. I., & Tayel, S. G. (2024) · Morphologie · doi:10.1016/j.morpho.2024.100940 · Cited by 1
Effectiveness of melatonin in preventing vancomycin-induced nephrotoxicity: an experimental study
Gergı̇n, Ö. Ö., Mat, Ö. C., Bolat, D., KABADAYI, M., Pehlivan, S. S., & Çoşkun, G. (2022) · Çukurova medical journal (Online)/Çukurova medical journal · doi:10.17826/cumj.1103876
Melatonin: A Saga of Health and Longevity
Gupta, S., Singh, A. K., Haldar, C., & Roy, A. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-22468-3_15
Zahran, F. M., Barakat, N. M., Ismail, E. S., & Khirallah, S. M. (2026) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2026.2640881
Nour, O. A., & Samaha, M. M. (2026) · Archiv der Pharmazie · doi:10.1002/ardp.70356
Bennaser, O. F., Amer, M. E., Othman, A. I., & El‑Missiry, M. A. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.104091
Topkaraoğlu, S., Sapmaz, T., Kuraş, S., Gürbüz, B., Erdem, E., Baki, K. B., Aktaş, S., & İrkörücü, O. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-06026-w
Metadata
- Authors
- Shi, S., Lei, S., Tang, C., Wang, K., & Xia, Z.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- University of Science and Technology of China (CN)
- Corresponding author
- Xia, Zhongyuan
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 2019-01
- Volume
- 39
- Issue
- 1
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- PMC
- PMC6331666
- OpenAlex
- W2906001979
- Cited by
- 135
- References
- 71
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 15 · 2023: 18 · 2022: 28 · 2021: 19 · 2020: 21 · 2019: 7
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Bioscience Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (WK9110000044, 81801175, 81671891)
- China Scholarship Council (201706270155)
- University of Science and Technology of China
- Fundamental Research Funds for the Central Universities (81801175, WK9110000044)
- School of Life Sciences and Biotechnology Division of Life Sciences, Korea University
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- melatonin, diabetic kidney, SIRT1, Nrf2, heme oxygenase-1, oxidative stress, apoptosis, streptozotocin-induced diabetes, EX527, SIRT1 inhibition, renal protection
- MeSH terms
- Animals, Carbazoles, Diabetes Mellitus, Experimental, Humans, Kidney, Melatonin, Signal Transduction, Reperfusion Injury, Apoptosis, Oxidative Stress, NF-E2-Related Factor 2, Rats, Heme Oxygenase-1, Sirtuin 1, Acute Kidney Injury
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