Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

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Melatonin: new insights on its therapeutic properties in diabetic complications

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Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis

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Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO‐1 Signaling Pathway to Protect the Kidney from Ischemia‐Reperfusion Injury

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Comprehensive overview of Nrf2-related epigenetic regulations involved in ischemia-reperfusion injury

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Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment

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Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells

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Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways

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NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis

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Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome

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Nrf-2 as a therapeutic target in acute kidney injury

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Melatonin as a powerful antioxidant

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Melatonin Alleviates Contrast‐Induced Acute Kidney Injury by Activation of Sirt3

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Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway

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Melatonin ameliorates cerebral ischemia‐reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1‐BMAL1 pathway

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Withania somnifera Ameliorates Doxorubicin-Induced Nephrotoxicity and Potentiates Its Therapeutic Efficacy Targeting SIRT1/Nrf2, Oxidative Stress, Inflammation, and Apoptosis

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Mesenchymal Stem Cell‐Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO‐1 Signaling Pathway

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Protective Effects of Melatonin Against Aristolochic Acid-Induced Nephropathy in Mice

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Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin

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Therapeutic Targets for Regulating Oxidative Damage Induced by Ischemia‐Reperfusion Injury: A Study from a Pharmacological Perspective

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Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway

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Small molecules as modulators of regulated cell death against ischemia/reperfusion injury

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Diosmetin alleviates acute kidney injury by promoting the TUG1/Nrf2/HO-1 pathway in sepsis rats

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Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats

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Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway

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Melatonin suppresses atherosclerosis by ferroptosis inhibition via activating NRF2 pathway

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Iron metabolism and ferroptosis in diabetic bone loss: from mechanism to therapy

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L‐carnitine reverses methotrexate‐induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC‐1α/Nrf2/HO‐1 axis

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FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy

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Perspective Adjunctive Therapies for COVID-19: Beyond Antiviral Therapy

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Melatonin Improves Endoplasmic Reticulum Stress-Mediated IRE1α Pathway in Zücker Diabetic Fatty Rat

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Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury)

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Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway

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The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair

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Melatonin improves periodontitis‐induced kidney damage by decreasing inflammatory stress and apoptosis in rats

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New insights into the role of melatonin in diabetic cardiomyopathy

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Sirtuin Family and Diabetic Kidney Disease

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Melatonin attenuates high glucose‑induced endothelial cell pyroptosis by activating the Nrf2 pathway to inhibit NLRP3 inflammasome activation

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Molecular pathophysiology of acute kidney injury: The role of sirtuins and their interactions with other macromolecular players

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Taxifolin Protects Against 5-Fluorouracil-Induced Cardiotoxicity in Mice Through Mitigating Oxidative Stress, Inflammation, and Apoptosis: Possible Involvement of Sirt1/Nrf2/HO-1 Signaling

Abukhalil, M. H., Al‐Alami, Z. M., Alfwuaires, M. A., Imran, M., Aladaileh, S. H., & Althunibat, O. Y. (2025) · Cardiovascular Toxicology · doi:10.1007/s12012-025-09962-w · Cited by 22

Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6 /Axl signaling

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Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1/Nrf2 signaling pathway and gut microbiota

Jiang, H., Mao, T., Sun, Z., Shi, L., Han, X., Zhang, Y., Zhang, X., Wang, J., Hu, J., Zhang, L., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1001778 · Cited by 23

Water extract of earthworms mitigates kidney injury triggered by oxidative stress via activating intrarenal Sirt1/Nrf2 cascade and ameliorating mitochondrial damage

Shu, G., Wang, C., Song, A., Zheng, Z., Zheng, S., Song, Y., Wang, X., Yu, H., Yin, S., & Deng, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118648 · Cited by 21

Renoprotective Potential of the Ultra-Pure Lipopolysaccharide from Rhodobacter Sphaeroides on Acutely Injured Kidneys in an Animal Model.

Aal-Aaboda, M. S., Abu-Raghif, A. R., & Hadi, N. R. (2021) · PubMed Central · doi:10.22092/ari.2021.356202.1803 · Cited by 20

Protective Effect of Melatonin for Renal Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis

Dun, R.-L., Lan, T.-Y., Tsai, J., Mao, J.-M., Shao, Y., Hu, X., Zhu, W., Qi, G.-C., & Peng, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.791036 · Cited by 20

Carnosine and crocin ameliorate oxidative stress in rats with rhabdomyolysis-induced acute kidney injury through upregulating HO-1 gene expression

El‐Ashmawy, N. E., Khedr, E. G., Doghish, A. S., & Elballal, M. S. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101972 · Cited by 20

Role of SET7/9 in the progression of ischemic renal injury in diabetic and non-diabetic rats

Sharma, N., Sankrityayan, H., Kale, A., & Gaikwad, A. B. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.05.075 · Cited by 20

Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats

Zhang, X., Zhu, Y., Zhou, Y., & Fei, B. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s246743 · Cited by 19

Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1α/NF-κB and SIRT1/p53 regulatory axes

Mansoure, A. N., Elshal, M., & Helal, M. G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111776 · Cited by 19

Current advances in the study of diabetic cardiomyopathy: From clinicopathological features to molecular therapeutics (Review)

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RNA-Seq identifies condition-specific biological signatures of ischemia-reperfusion injury in the human kidney

Park, M., Kwon, C. H., Ha, H. K., Han, M., & Song, S. H. (2020) · BMC Nephrology · doi:10.1186/s12882-020-02025-y · Cited by 19

Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model

Saha, M., Das, S., Manna, K., & Saha, K. D. (2023) · Bioscience Reports · doi:10.1042/bsr20230128 · Cited by 19

Herbal antioxidants and renal ischemic-reperfusion injury; an updated review

Asgharpour, M., Tolouian, A. C., Bhaskar, L. V., Tolouian, R., & Massoudi, N. (2020) · Journal of Nephropharmacology · doi:10.34172/npj.2021.03 · Cited by 19

Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34

Ostrycharz, E., Wasik, U., Kempińska‐Podhorodecka, A., Bañales, J. M., Milkiewicz, P., & Milkiewicz, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249667 · Cited by 18

Vitamin D, Cellular Senescence and Chronic Kidney Diseases: What Is Missing in the Equation?

Martinelli, R. P., Rayego‐Mateos, S., Alique, M., Márquez‐Expósito, L., Tejedor-Santamaria, L., Ortíz, A., González‐Parra, E., & Ruiz‐Ortega, M. (2023) · Nutrients · doi:10.3390/nu15061349 · Cited by 17

Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1

Owczarek, A., Gieczewska, K. B., Polańska, M. A., Paterczyk, B., Gruza, A., & Winiarska, K. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.572911 · Cited by 17

The renoprotective effects of Heme Oxygenase-1 during contrast-induced acute kidney injury in preclinical diabetic models

da Fonseca, C. D., Watanabe, M., Fernandes, S. M., dos Santos, A. A. C., Borges, F. T., & Vattimo, M. D. F. F. (2021) · Clinics · doi:10.6061/clinics/2021/e3002 · Cited by 15

Modulating SIRT1, Nrf2, and NF-κB signaling pathways by bergenin ameliorates the cadmium-induced nephrotoxicity in rats

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Effect of Lipopolysaccharide from Rhodobacter sphaeroides on Inflammatory Pathway and Oxidative Stress in Renal Ischemia/Reperfusion Injury in Male Rats.

Aal-Aaboda, M. S., Abu-Raghif, A. R., & Hadi, N. R. (2021) · PubMed Central · doi:10.22092/ari.2021.356003.1761 · Cited by 13

Melatonin prevents deterioration of erectile function in streptozotocin‐induced diabetic rats via sirtuin‐1 expression

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