Proteolysis of the collagen fibril in osteoarthritis
Abstract
The development of cartilage pathology in osteoarthritis involves excessive damage to the collagen fibrillar network, which appears to be mediated primarily by the chondrocyte-generated cytokines interleukin-1 and tumour necrosis factor α and the collagenases matrix metalloproteinase-1 (MMP-1) and MMP-13. The damage to matrix caused by these and other MMPs can result in the production of sufficient degradation products that can themselves elicit further degradation, leading to chondrocyte differentiation and eventually matrix mineralization and cell death. Knowledge of these MMPs, cellular receptors and cytokine pathways, and the ability to selectively antagonize them by selective blockade of function, may provide valuable therapeutic opportunities in the treatment of osteoarthritis and other joint diseases involving cartilage resorption, such as rheumatoid arthritis. The ability to detect the products of these degradative events released into body fluids of patients may enable us to monitor disease activity, predict disease progression and determine more rapidly the efficacy of new therapeutic agents.
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ADAMTS-4 and ADAMTS-5 are implicated prominently in cartilage breakdown during OA.
“During OA, ADAMTS-4 (aggrecanase 1) [28] and ADAMTS-5 (aggrecanase 2) [29,30] have been implicated prominently in cartilage breakdown.”
From Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage (2015) · cites this paper as [28]
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Tuska, P., Tóth, B. I., Vásárhelyi, G., et al. (2016) · Acta Veterinaria Hungarica · doi:10.1556/004.2016.017 · Cited by 1 · see citing works
“The product of the primary initiating event of this cleavage can be measured by immunoassay of a C1,2C neoepitope (Billinghurst et al., 1997; Poole et al., 2003; Celeste et al., 2005).”
BackgroundAntioxidant and Antiinflammatory Properties of Heme Oxygenase-1 in Osteoarthritic Articular Cells
Guillén, M. I., García-Arnandis, I., Clérigues, V., et al. (2012) · Springer eBooks · doi:10.1007/978-1-4614-6166-1_11
Le rôle de la cathepsine K dans le développement de l'ostéoarthrose équine
Vinardell, T. (2007) · doi:10.71781/3959
Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
Green, J. A. (2015) · UEA Digital Repository (University of East Anglia)
Molecular Biology Techniques in Musculoskeletal Research
von Rechenberg, B., & Hottiger, M. O. (2006) · Elsevier eBooks · doi:10.1016/b1-41-600123-9/50081-4
Upcoming value of gene expression analysis in rheumatology
Chetina, E. V., & Markova, G. A. (2018) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20186403221
Prospects for the Use of Gene Expression Analysis in Rheumatology
Chetina, E. V., & Markova, G. A. (2019) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750819010049
- Authors
- Poole, A. R., Nelson, F., Dahlberg, L., Tchetina, E., Kobayashi, M., Yasuda, T., Laverty, S., Squires, G., Kojima, T., Wu, W., & Billinghurst, R. C.
- Affiliations
- Shriners Hospitals for Children - Canada (CA)
- Corresponding author
- Nelson, Fred
- Dahlberg, Leif
- Tchetina, Elena
- Kobayashi, Masahiko
- Yasuda, Tadashi
- Laverty, Sheila
- Squires, Ginette
- Kojima, Toshihisa
- Wu, William
- ORCID
- Venue
- Biochemical Society Symposia
- Publisher
- Portland Press Ltd.
- Published
- 2003-09-01
- Volume
- 70
- Issue
- 70
- Pages
- 115-123
- ISSN
- 0067-8694 (ISSN-L)
- 1744-1439
- OpenAlex
- W1804092355
- Cited by
- 103
- References
- 0
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Society Symposia (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- osteoarthritis, collagen fibril degradation, matrix metalloproteinases, MMP-1, MMP-13, interleukin-1, TNF-α, chondrocytes, cartilage degeneration, chondrogenic differentiation, matrix mineralization, biomarkers, disease activity monitoring, rheumatoid arthritis, matrix metalloproteinase inhibitors
- MeSH terms
- Aging, Cartilage, Articular, Collagen, Humans, Hydrolysis, Osteoarthritis, Matrix Metalloproteinases
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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