Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of IκB Kinase through Suppression of Metalloproteinase Expression
Abstract
It has previously been shown that BMS-345541 [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline], a highly-selective inhibitor of IkappaB kinase (IKK), blocks both inflammation and joint destruction in murine collagen-induced arthritis. Although this agent has been shown to inhibit nuclear factor-kappaB-dependent cytokine expression in mice, we examined whether the inhibitor directly inhibits cytokine-driven metalloproteinase expression and cartilage degradation. In SW-1353 human chondrosarcoma cells, BMS-345541 inhibited interleukin-1 (IL-1)-dependent expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 in a concentration-dependent manner. IL-1 treatment failed to induce and BMS-345541 did not inhibit the expression of aggrecanases ADAMTS-4 (a disintegrin and metalloproteinase domain with thrombospondin motif) and ADAMTS-5, as well as the tissue inhibitor of metalloproteinase-3. In bovine cartilage explant cultures stimulated with IL-1 to induce aggrecan and collagen degradation over 3 weeks of culture, BMS-345541 was effective in inhibiting the degradation of both aggrecan and collagen. Secreted ADAMTS-4 was not inhibited by BMS-345541 in these explants, whereas ADAMTS-5 secretion was blocked in the same concentration range that inhibited aggrecan degradation. The ability of the IKK inhibitor to block aggrecan and collagen degradation through suppression of metalloproteinase expression, coupled with its ability to block inflammatory cytokine production, shows IKK to be a promising target for the development of novel agents to treat arthritic diseases.
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ADAMTS-4 and ADAMTS-5 are implicated prominently in cartilage breakdown during OA.
“During OA, ADAMTS-4 (aggrecanase 1) [28] and ADAMTS-5 (aggrecanase 2) [29,30] have been implicated prominently in cartilage breakdown.”
From Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage (2015) · cites this paper as [30]
Cites
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 1× · see citing works
“IKK-2 appears to play a dominant role over IKK-1 in the activation of NF- B (Ghosh and Karin, 2002).”
BackgroundFarndale, R. W., Buttle, D. J., & Barrett, A. J. (1986) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(86)90306-5 · Cited by 3,313 · see citing works
Two Improved and Simplified Methods for the Spectrophotometric Determination of Hydroxyproline.
Bergman, I., & Loxley, R. (1963) · Analytical Chemistry · doi:10.1021/ac60205a053 · Cited by 1,514 · see citing works
The IKK NF-κB system: a treasure trove for drug development
Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364 · see citing works
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Stanton, H., Rogerson, F. M., East, C. J., Golub, S. B., Lawlor, K. E., Meeker, C. T., Little, C. B., Last, K., Farmer, P. J., Campbell, I. K., et al. (2005) · Nature · doi:10.1038/nature03417 · Cited by 920 · see citing works
Vincenti, M. P., & Brinckerhoff, C. E. (2002) · Arthritis Research & Therapy · doi:10.1186/ar401 · Cited by 796 · see citing works
Yoshihara, Y., Nakamura, H., Obata, K., Yamada, H., Hayakawa, T., Fujikawa, K., & Okada, Y. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.6.455 · Cited by 566 · see citing works
Burke, J. R., Pattoli, M. A., Gregor, K. R., Brassil, P. J., MacMaster, J. F., McIntyre, K. W., Yang, X., Iotzova, V. S., Clarke, W., Strnad, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209677200 · Cited by 550 · see citing works
Self-citationTIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)
Kashiwagi, M., Tortorella, M. D., Nagase, H., & Brew, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000848200 · Cited by 509 · see citing works
Liacini, A. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00180-0 · Cited by 312 · see citing works
Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage
Pratta, M. A., Yao, W., Decicco, C. P., Tortorella, M. D., Liu, R.-Q., Copeland, R. A., Magolda, R. L., Newton, R. C., Trzăskos, J. M., & Arner, E. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303737200 · Cited by 292 · see citing works
Ruocco, M. G., Maeda, S., Park, J. M., Lawrence, T., Hsu, L.-C., Cao, Y., Schett, G., Wagner, E. F., & Karin, M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042081 · Cited by 252 · see citing works
McIntyre, K. W., Shuster, D. J., Gillooly, K. M., Dambach, D. M., Pattoli, M. A., Lu, P., Zhou, X., Qiu, Y., Zusi, F. C., & Burke, J. R. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11131 · Cited by 217 · see citing works
Self-citationBondeson, J., Foxwell, B. M. J., Brennan, F. M., & Feldmann, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5668 · Cited by 207 · see citing works
Dai, S., Hirayama, T., Abbas, S., & Abu‐Amer, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400258200 · Cited by 196 · see citing works
Aggrecanase-mediated cartilage degradation
Arner, P. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00148-0 · Cited by 178 · see citing works
Cowell, S., Knäuper, V., STEWART, M. L., d’Ortho, M., Stanton, H., Hembry, R. M., López-Otı́n, C., Reynolds, J. J., & Murphy, G. (1998) · Biochemical Journal · doi:10.1042/bj3310453 · Cited by 173 · see citing works
Keyszer, G. M., Lambiri, I., Nagel, R., Keysser, C., Keysser, M., Gromnica‐Ihle, E., Franz, J. K., Burmester, G. R., & Jung, K. (1999) · PubMed · Cited by 157 · see citing works
Vincenti, M. P., & Brinckerhoff, C. (2001) · Arthritis Research & Therapy · doi:10.1186/ar331 · Cited by 152 · see citing works
Joint cartilage degradation : basic and clinical aspects
Woessner, J. F., & Howell, D. S. (1993) · M. Dekker eBooks · Cited by 151 · see citing works
Kozacı, L. D., Buttle, D. J., & Hollander, A. P. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400121 · Cited by 122 · see citing works
Expression and activity of ADAMTS‐5 in synovium
Vankemmelbeke, M. N., Holen, I., Wilson, A. G., Ilic, M. Z., Handley, C. J., Kelner, G. S., Clark, M. E., Liu, C., Maki, R. A., Burnett, D. A., et al. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.01990.x · Cited by 116 · see citing works
Proteolysis of the collagen fibril in osteoarthritis
Poole, A. R., Nelson, F., Dahlberg, L., Tchetina, E., Kobayashi, M., Yasuda, T., Laverty, S., Squires, G., Kojima, T., Wu, W., et al. (2003) · Biochemical Society Symposia · doi:10.1042/bss0700115 · Cited by 103 · cited 2× · see citing works
“Metalloproteinases such as MMP-1 and MMP-13 have major roles in the degradation of collagen (Poole et al., 2003), whereas the aggrecanases ADAMTS-4 and ADAMTS-5 appear to mediate the aggrecan degradation (Arner, 2002).”
BackgroundGendron, C. M., Kashiwagi, M., Hughes, C., Caterson, B., & Nagase, H. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01295-x · Cited by 89 · see citing works
Fossati, G., Bucknall, R. C., & Edwards, S. W. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.1.13 · Cited by 89 · see citing works
Ellis, A. J., Curry, V. A., Powell, E. K., & Cawston, T. E. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1673 · Cited by 88 · see citing works
Is NF-κB a useful therapeutic target in rheumatoid arthritis?
Feldmann, M., Andreakos, E., Smith, C., Bondeson, J., Yoshimura, S., Kiriakidis, S., Monaco, C. G., Gasparini, C., Sacre, S. M., Lundberg, A. M., et al. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.suppl_2.ii13 · Cited by 85 · see citing works
Andreakos, E., Smith, C., Kiriakidis, S., Monaco, C. G., de Martin, R., Brennan, F. M., Paleolog, E. M., Feldmann, M., & Foxwell, B. M. J. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11044 · Cited by 65 · see citing works
Cuzzocrea, S., Chatterjee, P. K., Mazzon, E., McDonald, M. C., Dugo, L., Paola, R. D., Serraino, I., Britti, D., Caputi, A. P., & Thiemermann, C. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02338-5 · Cited by 61 · see citing works
Upregulation of enzymatic activity by interleukin-1 in osteoarthritis
Chevalier, X. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)87727-x · Cited by 52 · see citing works
Targeting I kappa B kinase for the treatment of inflammatory and other disorders.
Burke (2003) · PubMed · Cited by 38 · see citing works
Effects of methotrexate on normal articular cartilage in vitro and in vivo
Neidel, J., Sova, L., Schroers, B., Sintermann, F., Manzke, O., & Bohlen, H. (1998) · Annals of the Rheumatic Diseases · doi:10.1136/ard.57.7.414 · Cited by 16 · see citing works
Tardif, G., Dupuis, M., Reboul, P., Geng, C., Pelletier, J.-P., Ranger, P., & Pelletier, J. (2003) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(03)00079-7 · Cited by 10 · see citing works
Ho (2001) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200110)44:10 · Cited by 3 · see citing works
Romas (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200004)43:4
Flagged first, then by citations
Cited by
Sorted by citations
Wang, L., & He, C.-Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.967193 · Cited by 352 · see citing works
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis
Echtermeyer, F. G., Bertrand, J., Dreier, R., Meinecke, I., Neugebauer, K., Fuerst, M. E., Lee, Y. J., Song, Y. W., Herzog, C., Theilmeier, G., et al. (2009) · Nature Medicine · doi:10.1038/nm.1998 · Cited by 318 · see citing works
Update on the biology of the chondrocyte and new approaches to treating cartilage diseases
Goldring, M. B. (2006) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2006.06.003 · Cited by 295 · see citing works
Sheu, S.-Y., Ho, S.-R., Sun, J.-S., Chen, C.-Y., & Ke, C.-J. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0520-z · Cited by 181 · see citing works
The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.
Bondeson, J., Wainwright, S., Hughes, C., & Caterson, B. (2008) · PubMed · Cited by 181 · see citing works
Xu, J., Wang, W., Clark, C. C. A., & Brighton, C. T. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.07.001 · Cited by 128 · see citing works
Fosang, A., Rogerson, F. M., East, C. J., & Stanton, H. (2008) · European Cells and Materials · doi:10.22203/ecm.v015a02 · Cited by 97 · see citing works
Molecular mechanisms of cartilage remodelling in osteoarthritis
Bertrand, J., Cromme, C., Umlauf, D., Frank, S., & Pap, T. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.06.022 · Cited by 92 · see citing works
Chen, J., Xuan, J., Gu, Y., Shi, K., Xie, J.-J., Chen, J., Zheng, Z., Chen, Y., Chen, X.-B., Wu, Y., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.093 · Cited by 89 · see citing works
Seki, S., Asanuma-Abe, Y., Masuda, K., Kawaguchi, Y., Asanuma, K., Muehleman, C., Iwai, A., & Kimura, T. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2851 · Cited by 88 · see citing works
IκB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges
Strnad, J., & Burke, J. R. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.01.005 · Cited by 85 · see citing works
Self-citationThe IL-1β/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis
Ji, Q., Xu, X.-J., Zhang, Q., Kang, L., Xu, Y., Zhang, K., Li, L., Liang, Y.-C., Hong, T., Ye, Q., et al. (2016) · Journal of molecular medicine · doi:10.1007/s00109-016-1418-z · Cited by 77 · see citing works
Li, L., Lv, G., Wang, B., & Kuang, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.015 · Cited by 79 · see citing works
Boileau, C., Martel‐Pelletier, J., Fahmi, H., Mineau, F., Boily, M., & Pelletier, J. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22726 · Cited by 74 · see citing works
Liu, C., Zhang, Y., Dai, B., Ma, Y., Zhang, Q., Wang, Y., & Yang, H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6698 · Cited by 72 · see citing works
Xu, Z., Ke, T., Zhang, Y., Guo, L., Chen, F., & He, W. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00329-9 · Cited by 70 · see citing works
Novel IκB kinase inhibitors for treatment of nuclear factor-κB-related diseases
Suzuki, J., Ogawa, M., Muto, S., Itai, A., Isobe, M., Hirata, Y., & Nagai, R. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.559162 · Cited by 69 · see citing works
LaVallie, E. R., Chockalingam, P. S., Collins‐Racie, L. A., Annis-Freeman, B., Keohan, C. C., Leitges, M., Dorner, A. J., Morris, E. A., Majumdar, M. K., & Arai, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601905200 · Cited by 63 · see citing works
STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Heuvel, F. O., Holl, S., Chandrasekar, A., Li, Z.-H., Wang, Y.-B., Rehman, R., Förstner, P., Sinske, D., Palmer, A., Wiesner, D., et al. (2019) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2019.06.019 · Cited by 51 · see citing works
Zhu, F., Wang, P., Lee, N. H., Goldring, M. B., & Κωνσταντόπουλος, Κ. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015174 · Cited by 49 · see citing works
Lu, W., Shi, J., Zhang, J., Lv, Z., Guo, F., Huang, H., Zhu, W., & Chen, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101522 · Cited by 47 · see citing works
New Approaches to the Treatment of Inflammatory Disease
Ivanenkov, Y. A., Balakin, K. V., & Tkachenko, S. E. (2008) · Drugs in R&D · doi:10.2165/0126839-200809060-00005 · Cited by 47 · see citing works
Modeling IL-1 induced degradation of articular cartilage
Kar, S., Smith, D. W., Gardiner, B. S., Li, Y., Wang, Y., & Grodzinsky, A. J. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.02.008 · Cited by 40 · see citing works
Syndecan-4 in intervertebral disc and cartilage: Saint or synner?
Binch, A. L. A., Shapiro, I. M., & Risbud, M. V. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.005 · Cited by 43 · see citing works
Nascimento, M. H. M., Ambrosio, F. N., Ferraraz, D. C., Neto, H. W., Querobino, S. M., Nascimento-Sales, M., Alberto-Silva, C., Christoffolete, M. A., Franco, M. K. K. D., Kent, B., et al. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112345 · Cited by 42 · see citing works
Kihara, S., Hayashi, S., Hashimoto, S., Kanzaki, N., Takayama, K., Matsumoto, T., Chinzei, N., Iwasa, K., Haneda, M., Takeuchi, K., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3080 · Cited by 39 · see citing works
TenBroek, E. M., Yunker, L., Nies, M. F., & Bendele, A. M. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-0921-5 · Cited by 37 · see citing works
Yoon, S.-W., Chun, J., Sung, M., Kim, J., & Poo, H. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.05.026 · Cited by 37 · see citing works
Sylvester, J., Mabrouk, M. E., Ahmad, R., Chaudry, A., & Zafarullah, M. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000341438 · Cited by 34 · see citing works
Metalloproteinases and metalloproteinase inhibitors in age-related diseases.
Gargiulo, S., Gamba, P., Poli, G., & Leonarduzzi, G. (2014) · Current pharmaceutical design · doi:10.2174/13816128113196660701 · Cited by 30 · see citing works
Novel Tricyclic Inhibitors of IκB Kinase
Kempson, J., Spergel, S. H., Guo, J., Quesnelle, C. A., Gill, P., Belanger, D. S., Dyckman, A. J., Li, T., Watterson, S. H., Langevine, C. M., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm8015816 · Cited by 26 · see citing works
Self-citationGillooly, K. M., Pattoli, M. A., Taylor, T. L., Chen, L., Cheng, L., Gregor, K. R., Whitney, G. S., Susulic, V., Watterson, S. H., Kempson, J., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.156018 · Cited by 26 · see citing works
Self-citationBusschers, E., Holt, J. P., & Richardson, D. W. (2010) · American Journal of Veterinary Research · doi:10.2460/ajvr.71.2.176 · Cited by 25 · see citing works
Roles of long non‑coding RNA in osteoarthritis (Review)
Wang, J., Sun, Y., Liu, J., Yang, B., Wang, T., Zhang, Z., Jiang, X., Guo, Y., & Zhang, Y. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4966 · Cited by 24 · see citing works
Lima, E. G., Tan, A. R., Tai, T., Bian, L., Ateshian, G. A., Cook, J. L., & Hung, C. T. (2008) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.06.015 · Cited by 24 · see citing works
Zhu, X., Li, Q., Hu, G., Wang, J., Hu, Q., Liu, Z., Wu, G., & Zhong, Y. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3762 · Cited by 21 · see citing works
Zhang, Y., Weng, Q., Chen, J., Li, M., & Han, J. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9819 · Cited by 20 · see citing works
Kempson, J., Guo, J., Das, J., Moquin, R. V., Spergel, S. H., Watterson, S. H., Langevine, C. M., Dyckman, A. J., Pattoli, M. A., Burke, J. R., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.03.159 · Cited by 19 · see citing works
Self-citationRujirek, C., Ongchai, S., Tangyuenyong, S., Kongtawelert, P., Ampai, P., & Reutrakul, V. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr11.1633 · Cited by 17 · see citing works
Short- and long-term exposure of articular cartilage to curcumin or quercetin inhibits aggrecan loss
Lay, E., Samiric, T., Handley, C. J., & Ilic, M. Z. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.11.004 · Cited by 16 · see citing works
Graeser, A.-C., Giller, K., Wiegand, H., Barella, L., Boesch, C., & Rimbach, G. H. (2009) · Molecules · doi:10.3390/molecules15010027 · Cited by 16 · see citing works
Tao, Q., Ren, J., & Li, J. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00482.x · Cited by 12 · see citing works
van Geffen, E. W., van Caam, A., Vitters, E. L., van Beuningen, H. M., van de Loo, F. A., van Lent, P. L. E. M., Koenders, M. I., & van der Kraan, P. M. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0267 · Cited by 11 · see citing works
Lin, C., Naruphontjirakul, P., Huang, T., Wu, Y., Cheng, W.-H., & Su, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168560 · Cited by 9 · see citing works
Ding, W., Ge, Y., Sun, H., Xu, J., Gu, H., Bian, C., Chen, H., Jiang, L., & Yin, X. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.02.129 · Cited by 9 · see citing works
Takeuchi, K., Hayashi, S., Matumoto, T., Hashimoto, S., Takayama, K., Chinzei, N., Kihara, S., Haneda, M., Kirizuki, S., Kuroda, Y., et al. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3729 · Cited by 9 · see citing works
Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage
Goldring, M. B. (2007) · Springer eBooks · doi:10.1007/978-1-84628-701-5_3 · Cited by 7 · see citing works
Zhang, X., Zhang, R., Wang, Y., Li, L., & Zhong, Z. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01415-5 · Cited by 6 · see citing works
Identification of biomarkers and regulatory networks for cartilage damage patients
Liu, B., & Xiao, X. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2702050 · Cited by 2 · see citing works
Cartilage Extracellular Matrix Integrity and OA
Chathuraka, T., & Che, Q. (2012) · InTech eBooks · doi:10.5772/27533 · Cited by 2 · see citing works
Effects of Diosmin on IL-1β- Induced Inflammatory Response in Primary Rat Chondrocytes
Wu, C., Liang, C., Sun, J., Zhang, Z., & Pan, X. (2022) · International Journal of Pharmacology · doi:10.3923/ijp.2022.667.672 · Cited by 1 · see citing works
Yadegari, M., Orazizadeh, M., Hashemitabar, M., & Khodadadi, A. (1996) · Europe PMC (PubMed Central) · doi:10.6091/ibj.1009.2012 · Cited by 1 · see citing works
Lemke, A. K., Sandy, J. D., Voigt, H., Dreier, R., Lee, J. H., Grodzinsky, A. J., Mentlein, R., Fay, J., Schünke, M., & Kurz, B. (2010)
Orazizadeh, M., Yadegari, M., Hashemitabar, M., & Khodadadi, A. (2013) · Asian Biomedicine · doi:10.5372/1905-7415.0701.151
Tao, Q., Ren, J., & Jie-shou, L. I. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00482.x
BindingDB Entry 3137: Novel tricyclic inhibitors of IkappaB kinase.
BindingDB (2009) · UC San Diego · doi:10.7270/q2db804m
Ewald, K. (2011) · MACAU: Open Access Repository of Kiel University (University Library Kiel)
- Authors
- Pattoli, M. A., MacMaster, J. F., Gregor, K. R., & Burke, J. R.
- Affiliations
- Bristol-Myers Squibb (United States) (US)
- ORCID
- Burke, James R.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 315
- Issue
- 1
- Pages
- 382-388
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2142218883
- Cited by
- 56
- References
- 36
- Citations by year
- 2024: 2 · 2022: 3 · 2021: 5 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- BMS-345541, IκB kinase inhibitors, interleukin-1, cartilage degeneration, aggrecan degradation, collagen degradation, matrix metalloproteinases, ADAMTS5, ADAMTS-4, TIMP-3, NF-κB signaling, chondrocytes, cartilage explants, arthritis
- MeSH terms
- ADAMTS5 Protein, ADAMTS4 Protein, Animals, Cartilage, Cattle, Collagen, Humans, Imidazoles, Interleukin-1, Phosphorylation, Procollagen N-Endopeptidase, Proteoglycans, Quinoxalines, Gene Expression Regulation, Enzymologic, Extracellular Matrix Proteins, Chondrocytes, Lectins, C-Type, Metalloproteases, Protein Kinase Inhibitors, ADAM Proteins, Aggrecans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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