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ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion
Abstract
Conference Article| February 01 1990 ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion FRANCES M. ASHCROFT; FRANCES M. ASHCROFT 1University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar PATRIK RORSMAN PATRIK RORSMAN * 1University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1990) 18 (1): 109–111. https://doi.org/10.1042/bst0180109 Article history Received: July 24 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation FRANCES M. ASHCROFT, PATRIK RORSMAN; ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion. Biochem Soc Trans 1 February 1990; 18 (1): 109–111. doi: https://doi.org/10.1042/bst0180109 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: KATP channel, ATP-sensitive K+channel, PKC, protein kinase C, PMA, phorbol 12-myristate 13-acetate This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
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“The K ATP channel has a central function in glucosestimulated insulin release, transducing an increase in ATP into depolarisation with voltage-dependent influx of Ca 2+ [37].”
From Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells (2007) · cites this paper as [37]
In the citing paper
“Initiation of secretion is generally attributed to depolarization with increase of [Ca 2ϩ ] i after closure of K ATP channels (19).”
From Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations (2006) · cites this paper as [19]
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Qin, G.-Q., Chen, L., Zheng, J., Wu, X., Yang, L., Yang, K., Liu, T.-F., Fang, Z., & Zhang, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1195354 · Cited by 13
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“The mechanism of glucose-stimulated insulin secretion (in which the penultimate signal-transduction event is the influx of extracellular calcium ions) has been documented elsewhere (Dukes et al., 1994; Ashcroft and Rorsman, 1990; Pralong et al., 1990).”
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“, 2017) due to the fact that plasma membrane of these cells contains ATP-sensitive K+ (KATP) channels which remain open in normal conditions and voltage-gated Ca2+ channels which remain closed (Ashcroft and Rorsman, 1990; MacDonald et al., 2005).”
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Metadata
- Authors
- ASHCROFT, F. M., & RORSMAN, P.
- Affiliations
- University of Oxford (GB)
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 1990-02-01
- Volume
- 18
- Issue
- 1
- Pages
- 109-111
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2355414246
- Cited by
- 145
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 5 · 2012: 8
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- ATP-sensitive potassium channels, B cell metabolism, insulin secretion, pancreatic beta cells, protein kinase C, phorbol myristate acetate
- MeSH terms
- Insulin Secretion, Adenosine Triphosphate, Animals, Humans, Insulin, Islets of Langerhans, Potassium Channels
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