Ashcroft, Frances M.

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

Gloyn, A. L., Pearson, E. R., Antcliff, J. F., Proks, P., Bruining, G. J., Slingerland, A. S., Howard, N., Srinivasan, S., Silva, J. M. C. L., Molnes, J., et al. (2004) · New England Journal of Medicine

Pancreatic function and diabetesIon channel regulation and function

Cited by 1,137

Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

Ashcroft, F. M., Harrison, D. E., & Ashcroft, S. J. H. (1984) · Nature

Pancreatic function and diabetesIon channel regulation and function

Cited by 1,113

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

Pearson, E. R., Flechtner, I., Njølstad, P. R., Malecki, M. T., Flanagan, S. E., Larkin, B., Ashcroft, F. M., Klimes, I., Codner, E., Iotova, V., et al. (2006) · New England Journal of Medicine

Pancreatic function and diabetesIon channel regulation and function

Cited by 988

Diabetes Mellitus and the β Cell: The Last Ten Years

Ashcroft, F. M., & Rorsman, P. (2012) · Cell

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 902

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews

Pancreatic function and diabetesIon channel regulation and function

Cited by 793

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007) · Cell Metabolism

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 695

Sulfonylurea Stimulation of Insulin Secretion

Proks, P., Reimann, F., Green, N., Gribble, F., & Ashcroft, F. (2002) · Diabetes

Ion channel regulation and functionPancreatic function and diabetes

Cited by 510

Cloning and functional expression of the cDNA encoding a novel ATP‐sensitive potassium channel subunit expressed in pancreatic β‐cells, brain, heart and skeletal muscle

Sakura, H., Ämmälä, C., Smith, P. A., Gribble, F. M., & Ashcroft, F. M. (1995) · FEBS Letters

Ion channel regulation and functionPancreatic function and diabetes

Cited by 411

KATP channels and islet hormone secretion: new insights and controversies

Ashcroft, F. M., & Rorsman, P. (2013) · Nature Reviews Endocrinology

Pancreatic function and diabetesIon channel regulation and function

Cited by 272

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis, I. I., Dace, W., Mattis, K. K., Ramracheya, R., et al. (2014) · Nature Communications

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 259

Stimulus-secretion coupling in pancreatic β cells

Ashcroft, F. M., Proks, P., Smith, P. A., Ämmälä, C., Bokvist, K., & Rorsman, P. (1994) · Journal of Cellular Biochemistry

Pancreatic function and diabetesIon channel regulation and function

Cited by 255

The ATP‐sensitivity of K+ channels in rat pancreatic B‐cells is modulated by ADP

Kakei, M., Kelly, R. P., Ashcroft, S. J. H., & Ashcroft, F. M. (1986) · FEBS Letters

Ion channel regulation and functionPancreatic function and diabetes

Cited by 241

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

Zhang, Q., Ramracheya, R., Lahmann, C., Tarasov, A., Bengtsson, M., Braha, O., Braun, M., Brereton, M., Collins, S., Galvanovskis, J., et al. (2013) · Cell Metabolism

Pancreatic function and diabetesIon channel regulation and function

Cited by 225

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

Ellard, S., Flanagan, S. E., Girard, C. A., Patch, A.-M., Harries, L. W., Parrish, A., Edghill, E. L., Mackay, D. J. G., Proks, P., Shimomura, K., et al. (2007) · The American Journal of Human Genetics

Pancreatic function and diabetesIon channel regulation and function

Cited by 215

MgATP activates the β cell K ATP channel by interaction with its SUR1 subunit

Gribble, F. M., Tucker, S. J., Haug, T., & Ashcroft, F. M. (1998) · Proceedings of the National Academy of Sciences

Ion channel regulation and functionPancreatic function and diabetes

Cited by 171

Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP

Trapp, S., Proks, P., Tucker, S. J., & Ashcroft, F. M. (1998) · The Journal of General Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 170

Simultaneous recordings of glucose dependent electrical activity and ATP‐regulated K+‐currents in isolated mouse pancreatic β‐cells

Smith, P. A., Ashcroft, F. M., & Rorsman, P. (1990) · FEBS Letters

Pancreatic function and diabetesIon channel regulation and function

Cited by 169

3‐D structural and functional characterization of the purified KATP channel complex Kir6.2–SUR1

Mikhailov, M. V., Campbell, J. D., de Wet, H., Shimomura, K., Zadek, B., Collins, R. F., Sansom, M. S., Ford, R. C., & Ashcroft, F. M. (2005) · The EMBO Journal

Ion channel regulation and functionATP Synthase and ATPases Research

Cited by 168

The Interaction of nucleotides with the tolbutamide block of cloned atp‐sensitive k+ channel currents expressed in xenopus oocytes: a reinterpretation

Gribble, F. M., Tucker, S. J., & Ashcroft, F. M. (1997) · The Journal of Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 161

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Vergari, E., Knudsen, J. G., Ramracheya, R., Salehi, A., Zhang, Q., Adam, J., Asterholm, I. W., Benrick, A., Briant, L. J. B., Chibalina, M. V., et al. (2019) · Nature Communications

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 152

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules

Hoppa, M. B., Collins, S., Ramracheya, R., Hodson, L., Amisten, S., Zhang, Q., Johnson, P., Ashcroft, F. M., & Rorsman, P. (2009) · Cell Metabolism

Pancreatic function and diabetesCellular transport and secretion

Cited by 152

ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion

ASHCROFT, F. M., & RORSMAN, P. (1990) · Biochemical Society Transactions

Pancreatic function and diabetesIon channel regulation and function

Cited by 145

Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic β -cells

Smith, P. A., Rorsman, P., & Ashcroft, F. M. (1989) · Nature

Pancreatic function and diabetesIon channel regulation and function

Cited by 143

Electrogenic arginine transport mediates stimulus‐secretion coupling in mouse pancreatic beta‐cells.

Smith, P. A., Sakura, H., Coles, B., Gummerson, N., Proks, P., & Ashcroft, F. M. (1997) · The Journal of Physiology

Pancreatic function and diabetesAmino Acid Enzymes and Metabolism

Cited by 142