The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection
Abstract
It is beyond doubt that the neurotrophin family of proteins plays key roles in determining the fate of the neuron, not only during embryonic development, but also in the adult brain. Neurotrophins such as NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) can play dual roles: first, in neuronal survival and death, and, secondly, in activity-dependent plasticity. The neurotrophins manifest their effects by binding to two discrete receptor subtypes: the Trk (tropomyosin receptor kinase) family of RTKs (receptor tyrosine kinases) and the p75NTR (p75 neurotrophin receptor). The differential activation of these receptors by the mature neurotrophins and their precursors, the proneurotrophins, renders analysis of the biological functions of these receptors in the adult brain highly complex. Here, we briefly give a broad review of current knowledge of the roles of neurotrophins in the adult brain, including expression of hippocampal plasticity, neurodegeneration and exercise-induced neuroprotection.
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Cites
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Sortilin is essential for proNGF-induced neuronal cell death
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Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
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Long-term potentiation and memory
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Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882
Kluding, P. M., Pasnoor, M., Singh, R., Jernigan, S., Farmer, K., Rucker, J., Sharma, N. K., & Wright, D. E. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.05.007 · Cited by 370
Lau, Y.-S., Patki, G., Das-Panja, K., Le, W.-D., & Ahmad, S. O. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07626.x · Cited by 275
Duman, R. S. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/rsduman · Cited by 210
Liu, X., Chan, C.-B., Jang, S.-W., Pradoldej, S., Huang, J., He, K., Phun, L. H., France, S., Xiao, G., Jia, Y., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm101206p · Cited by 208
Metadata
- Authors
- Hennigan, A., O'Callaghan, R. M., & Kelly, Á. M.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2007-03-20
- Volume
- 35
- Issue
- 2
- Pages
- 424-427
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W1994304888
- Cited by
- 245
- References
- 7
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hennigan, A., O'Callaghan, R. M., & Kelly, Á. M. (2007). Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection. Biochemical Society Transactions. https://doi.org/10.1042/bst0350424
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
