Long-term potentiation and memory
Open accessAbstract
The discovery of long-term potentiation (LTP) transformed research on the neurobiology of learning and memory. This did not happen overnight, but the discovery of an experimentally demonstrable phenomenon reflecting activity-driven neuronal and synaptic plasticity changed discussions about what might underlie learning from speculation into something much more concrete. Equally, however, the relationship between the discovery of LTP and research on the neurobiology of learning and memory has been reciprocal; for it is also true that studies of the psychological, anatomical and neurochemical basis of memory provided a developing and critical intellectual context for the physiological discovery. The emerging concept of multiple memory systems, from 1970 onwards, paved the way for the development of new behavioural and cognitive tasks, including the watermaze described in this paper. The use of this task in turn provided key evidence that pharmacological interference with an LTP induction mechanism would also interfere with learning, a finding that was by no means a foregone conclusion. This reciprocal relationship between studies of LTP and the neurobiology of memory helped the physiological phenomenon to be recognized as a major discovery.
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Hebb, D. O. (2005) · doi:10.4324/9781410612403 · Cited by 9,825 · see citing works
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010 · see citing works
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322 · see citing works
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
Self-citationThe hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151 · see citing works
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Self-citationSynaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works
Self-citationSimple memory: a theory for archicortex
Marr, D. (1971) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1971.0078 · Cited by 2,771 · see citing works
Spatial localization does not require the presence of local cues
Morris, R. G. M. (1981) · Learning and Motivation · doi:10.1016/0023-9690(81)90020-5 · Cited by 2,699 · see citing works
Self-citationCollingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413 · see citing works
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088 · see citing works
Remembrance of places passed: Spatial memory in rats.
Olton, D. S., & Samuelson, R. J. (1976) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.2.2.97 · Cited by 1,934 · see citing works
McGaugh, J. L. (1966) · Science · doi:10.1126/science.153.3742.1351 · Cited by 1,468 · see citing works
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116 · see citing works
The Biochemistry of Memory: A New and Specific Hypothesis
LYNCH, G. S., & Baudry, M. (1984) · Science · doi:10.1126/science.6144182 · Cited by 1,045 · see citing works
"Attention-like" processes in classical conditioning
Kamin, L. J. (1967) · NASA Technical Reports Server (NASA) · Cited by 716 · see citing works
New Method of Testing Long-term Retention with Special Reference to Amnesic Patients
Warrington, E. K., & Weiskrantz, L. (1968) · Nature · doi:10.1038/217972a0 · Cited by 692 · see citing works
Gaffan, D. (1974) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0037649 · Cited by 600 · see citing works
Neurobiology of the hippocampus
Seifert, W. E. (1983) · Academic Press eBooks · Cited by 530 · see citing works
Impaired Spatial Learning after Saturation of Long-Term Potentiation
Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M. (1998) · Science · doi:10.1126/science.281.5385.2038 · Cited by 505 · see citing works
Self-citation(1994) · The MIT Press eBooks · doi:10.7551/mitpress/4545.001.0001 · Cited by 485 · see citing works
An analysis of short-term visual memory in the monkey.
Mishkin, M. M., & Delacour, J. (1975) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.1.4.326 · Cited by 470 · see citing works
New life in an old idea: The synaptic plasticity and memory hypothesis revisited
Martin, S. J., & Morris, R. (2002) · Hippocampus · doi:10.1002/hipo.10107 · Cited by 440 · see citing works
Self-citationMcNaughton, B. L., Barnes, C. A., RAO, G. R., Baldwin, J., & Rasmussen, M. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-02-00563.1986 · Cited by 327 · see citing works
Bliss, T. V. P., & Lømo, T. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010273 · Cited by 135 · see citing works
A theory of pavlovian conditioning: The effectiveness of reinforcement and non-reinforcement
Rescorla, R. A. (1972) · Medical Entomology and Zoology · Cited by 108 · see citing works
Staubli, U. V., Larson, J., Thibault, O., Baudry, M., & LYNCH, G. S. (1988) · Brain Research · doi:10.1016/0006-8993(88)90922-5 · Cited by 94 · see citing works
An analysis of short-term visual memory in the monkey.
Mishkin, M., & Delacour, J. (1975) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.1.4.326 · Cited by 92 · see citing works
Morris, R., Hagan, J. J., Nadel, L., Jensen, J. R., Baudry, M., & LYNCH, G. S. (1987) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(87)90448-1 · Cited by 20 · see citing works
Self-citationA prelude to long-term potentiation
Andersen, P. N. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1232 · Cited by 18 · see citing works
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Abbott, L. F., & Regehr, W. G. (2004) · Nature · doi:10.1038/nature03010 · Cited by 1,684 · see citing works
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193 · see citing works
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Kandel, E. R. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-14 · Cited by 904 · see citing works
Postsynaptic receptor trafficking underlying a form of associative learning
Rumpel, S., LeDoux, J., Zador, A., & Malinow, R. (2005) · Science · doi:10.1126/science.1103944 · Cited by 775 · see citing works
BDNF is essential to promote persistence of long-term memory storage
Bekinschtein, P., Cammarota, M., Katche, C., Slipczuk, L. N., Rossato, J. I., Goldin, A. P., Izquierdo, I., & Medina, J. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711863105 · Cited by 658 · see citing works
BDNF signaling in context: From synaptic regulation to psychiatric disorders
Wang, C. S., Kavalali, E. T., & Monteggia, L. M. (2021) · Cell · doi:10.1016/j.cell.2021.12.003 · Cited by 629 · see citing works
The mechanisms for pattern completion and pattern separation in the hippocampus
Rolls, E. T. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00074 · Cited by 545 · see citing works
A computational theory of hippocampal function, and empirical tests of the theory
Rolls, E. T., & Kesner, R. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.04.005 · Cited by 608 · see citing works
Alzheimer's disease: synaptic dysfunction and Aβ
Shankar, G. M., & Walsh, D. M. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-48 · Cited by 522 · see citing works
Aggleton, J. P., O’Mara, S. M., Vann, S. D., Wright, N. F., Tsanov, M., & Erichsen, J. T. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07251.x · Cited by 468 · see citing works
Moosmang, S., Haider, N., Klugbauer, N., Adelsberger, H., Langwieser, N., Müller, J., Stieß, M., Marais, E., Schulla, V., Lacinová, Ľ., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1531-05.2005 · Cited by 418 · see citing works
The Regulation of Transcription in Memory Consolidation
Alberini, C. M., & Kandel, E. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021741 · Cited by 362 · see citing works
Neuromorphic Engineering: From Biological to Spike‐Based Hardware Nervous Systems
Yang, J., Wang, R., Ren, Y., Mao, J., Wang, Z., Zhou, Y., & Han, S. (2020) · Advanced Materials · doi:10.1002/adma.202003610 · Cited by 353 · see citing works
A computational theory of hippocampal function, and tests of the theory: New developments
Kesner, R. P., & Rolls, E. T. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.009 · Cited by 347 · see citing works
Advancing translational research with the Semantic Web
Ruttenberg, A., Clark, T., Bug, W., Samwald, M., Bodenreider, O., Chen, H., Doherty, D. W., Forsberg, K., Gao, Y. C., Kashyap, V., et al. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-s3-s2 · Cited by 330 · see citing works
Revett, T. J., Baker, G. B., Jhamandas, J. H., & Kar, S. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110190 · Cited by 294 · see citing works
A computational theory of episodic memory formation in the hippocampus
Rolls, E. T. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.027 · Cited by 271 · see citing works
BDNF activates mTOR to regulate GluR1 expression required for memory formation
Slipczuk, L., Bekinschtein, P., Katche, C., Cammarota, M., Izquierdo, I., & Medina, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006007 · Cited by 246 · see citing works
Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection
Hennigan, A., O'Callaghan, R., & Kelly, A. M. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350424 · Cited by 245 · see citing works
An attractor network in the hippocampus: Theory and neurophysiologyPreprint
Rolls, E. T. (2007) · Learning & Memory · doi:10.1101/lm.631207 · Cited by 232 · see citing works
Pattern separation, completion, and categorisation in the hippocampus and neocortex
Rolls, E. T. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.07.008 · Cited by 234 · see citing works
Molecular and systems mechanisms of memory consolidation and storage
Wang, H., Hu, Y., & Tsien, J. Z. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.004 · Cited by 205 · see citing works
Synaptic plasticity in animal models of early Alzheimer's disease
Rowan, M. J., Klyubin, I. V., Cullen, W. K., & Anwyl, R. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1240 · Cited by 202 · see citing works
Miller, P., Zhabotinsky, A. M., Lisman, J. E., & Wang, X.-J. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030107 · Cited by 199 · see citing works
Synaptic evidence for the efficacy of spaced learning
Kramár, E. A., Babayan, A. H., Gavin, C. F., Cox, C. D., Jafari, M., Gall, C. M., Rumbaugh, G., & Lynch, G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120700109 · Cited by 192 · see citing works
Kim, J. J., Koo, J. W., Lee, H. J., & Han, J.-S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4623-04.2005 · Cited by 184 · see citing works
Ampakines and the threefold path to cognitive enhancement
LYNCH, G. S., & Gall, C. M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.007 · Cited by 172 · see citing works
Kumar, A. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00007 · Cited by 169 · see citing works
Learning in Aplysia: looking at synaptic plasticity from both sides
Roberts, A. C., & Glanzman, D. L. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.014 · Cited by 157 · see citing works
Donald O. Hebb's synapse and learning rule: a history and commentary
Cooper, S. J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.009 · Cited by 159 · see citing works
Ovsepian, S. V., Anwyl, R., & Rowan, M. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03582.x · Cited by 153 · see citing works
Theoretical models of synaptic short term plasticity
Hennig, M. H. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00154 · Cited by 148 · see citing works
Batalha, V. L., Pego, J. M., Fontinha, B. M., Costenla, A. R., Valadas, J. S., Baqi, Y., Radjainia, H., Müller, C. E., Sebastião, A. M., & Lopes, L. V. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.8 · Cited by 136 · see citing works
Mechanism of acute tryptophan depletion: is it only serotonin?
van Donkelaar, E. L., Blokland, A., Ferrington, L., Kelly, P. A. T., Steinbusch, H. W. M., & Prickaerts, J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.9 · Cited by 127 · see citing works
Diamond, D., Park, C. R., Campbell, A. M., & Woodson, J. C. (2005) · Hippocampus · doi:10.1002/hipo.20107 · Cited by 128 · see citing works
A quantitative theory of the functions of the hippocampal CA3 network in memory
Rolls, E. T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00098 · Cited by 122 · see citing works
Cognition in the Chronic Pain Experience: Preclinical Insights
Phelps, C. E., Navratilova, E., & Porreca, F. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.01.001 · Cited by 120 · see citing works
Caffeine, Adenosine Receptors, and Synaptic Plasticity
Costenla, A. R., Cunha, R. A., & de Mendonça, A. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091384 · Cited by 132 · see citing works
The Role of Mitochondrial Calcium Homeostasis in Alzheimer’s and Related Diseases
Ryan, K. C., Ashkavand, Z., & Norman, K. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239153 · Cited by 107 · see citing works
Zheng, C., & Zhang, T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.071 · Cited by 106 · see citing works
Modi, M. N., Dhawale, A. K., & Bhalla, U. S. (2014) · eLife · doi:10.7554/elife.01982 · Cited by 106 · see citing works
Bliss, T., Collingridge, G. L., & Morris, R. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2003.1282 · Cited by 105 · see citing works
Self-citationMaking long-term memories in minutes: a spaced learning pattern from memory research in education
Kelley, P., & Whatson, T. S. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00589 · Cited by 106 · see citing works
Dopamine modulates synaptic plasticity in dendrites of rat and human dentate granule cells
Hamilton, T. J., Wheatley, B. M., Sinclair, D. B., Bachmann, M., Larkum, M. E., & Colmers, W. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011558107 · Cited by 99 · see citing works
Vouimba, R.-M., Muñoz, C., & Diamond, D. M. (2006) · Stress · doi:10.1080/10253890600610973 · Cited by 96 · see citing works
Grover, L. M., Kim, E., Cooke, J. D., & Holmes, W. R. (2009) · Learning & Memory · doi:10.1101/lm.1179109 · Cited by 93 · see citing works
Wang, W., Trieu, B. H., Palmer, L. C., Jia, Y., Pham, D. T., Jung, K., Karsten, C. A., Merrill, C. B., Mackie, K., Gall, C. M., et al. (2016) · eNeuro · doi:10.1523/eneuro.0160-16.2016 · Cited by 87 · see citing works
Hampson, R. E., Song, D. B., Chan, R. H. M., Sweatt, A. J., Riley, M. R., Gerhardt, G. A., Shin, D. C., Marmarelis, V. Z., Berger, T. W., & Deadwyler, S. A. (2012) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2012.2189163 · Cited by 89 · see citing works
Relationship of hippocampal theta and gamma oscillations to potentiation of synaptic transmission
Bikbaev, A. F. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.010.2008 · Cited by 87 · see citing works
Optimal Information Storage in Noisy Synapses under Resource Constraints
Varshney, L. R., Sjöström, P. J., & Chklovskii, D. B. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.017 · Cited by 85 · see citing works
Pharmacogenetics of major depressive disorder: top genes and pathways toward clinical applications
Fabbri, C., & Serretti, A. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0594-9 · Cited by 84 · see citing works
Memory formation, amnesia, improved memory and reversed amnesia: 5-HT role
Perez-Garcia, G., & Meneses, A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.11.027 · Cited by 81 · see citing works
Spike-timing dependent plasticity in the striatum
Fino, É. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00006 · Cited by 73 · see citing works
Pu, Z., Krugers, H. J., & Joëls, M. (2007) · Learning & Memory · doi:10.1101/lm.527207 · Cited by 72 · see citing works
Wiegert, O., Pu, Z., Shor, S., Joëls, M., & Krugers, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.039 · Cited by 87 · see citing works
Theoretical models of synaptic short term plasticity
Hennig, M. H. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00045 · Cited by 72 · see citing works
Kumar, A., Thinschmidt, J. S., Foster, T. C., & King, M. A. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00249.2007 · Cited by 69 · see citing works
Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory
Honoré, È., Khlaifia, A., Bosson, A., & Lacaille, J. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.687558 · Cited by 65 · see citing works
Shaffer, C. L., Hurst, R. S., Scialis, R. J., Osgood, S. M., Bryce, D. K., Hoffmann, W. E., Lazzaro, J. T., Hanks, A. N., Lotarski, S. M., Weber, M. L., et al. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.204735 · Cited by 61 · see citing works
Zhang, H., Shang, Y., Xiao, X., Yu, M., & Zhang, T. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.09.001 · Cited by 61 · see citing works
Epigenetic Control of Learning and Memory inDrosophilaby Tip60 HAT Action
Xu, S., Wilf, R., Menon, T., Panikker, P., Sarthi, J. B., & Elefant, F. (2014) · Genetics · doi:10.1534/genetics.114.171660 · Cited by 60 · see citing works
Effects of pharmacological manipulations of NMDA-receptors on deliberation in the Multiple-T task
Blumenthal, A., Steiner, A. P., Seeland, K. D., & Redish, A. D. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.01.011 · Cited by 59 · see citing works
Sex differences in synaptic plasticity underlying learning
Gall, C. M., Le, A. A., & LYNCH, G. S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24844 · Cited by 59 · see citing works
Bétry, C., Etiévant, A., Pehrson, A., Sánchez, C., & Haddjeri, N. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.12.002 · Cited by 59 · see citing works
Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta)
Lisman, J. E. (2017) · Molecular Brain · doi:10.1186/s13041-017-0337-4 · Cited by 62 · see citing works
Cazakoff, B. N., & Howland, J. G. (2009) · Hippocampus · doi:10.1002/hipo.20738 · Cited by 58 · see citing works
Catching the engram: strategies to examine the memory trace
Sakaguchi, M., & Hayashi, Y. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-32 · Cited by 57 · see citing works
Age-related memory decline, dysfunction of the hippocampus and therapeutic opportunities
Dahan, L., Rampon, C., & Florian, C. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109943 · Cited by 58 · see citing works
Continual learning and catastrophic forgetting
van de Ven, G. M., Soures, N., & Kudithipudi, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00073-0 · Cited by 81 · see citing works
Visual Imprinting in Birds: Behavior, Models, and Neural Mechanisms
McCabe, B. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00658 · Cited by 55 · see citing works
An, L., & Zhang, T. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.06.009 · Cited by 55 · see citing works
The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks
Izquierdo, I., Cammarota, M., da Silva, W. C. F. N., Bevilaqua, L. R., Rossato, J. I., Bonini, J. S., Mello, P. B., Benetti, F., da Costa, J. C., & Medina, J. H. (2008) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652008000100007 · Cited by 53 · see citing works
Fornical Closed-Loop Stimulation for Alzheimer’s Disease
Senova, S., Chaillet, A., & Lozano, A. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.015 · Cited by 53 · see citing works
A Multi-functional Memristive Pavlov Associative Memory Circuit Based on Neural Mechanisms
Zhang, Y., & Zeng, Z. (2021) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2021.3108354 · Cited by 51 · see citing works
Exploring the dual character of metformin in Alzheimer's disease
Ning, P., Luo, A., Mu, X. L., Xu, Y., & Li, T. X. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108966 · Cited by 51 · see citing works
Kouvaros, S., & Papatheodoropoulos, C. (2016) · Hippocampus · doi:10.1002/hipo.22655 · Cited by 50 · see citing works
Qu, Z., Jia, L., Xie, T., Zhen, J., Si, P., Cui, Z., Xue, Y., Sun, C., & Wang, W. (2019) · Medical Science Monitor · doi:10.12659/msm.915025 · Cited by 50 · see citing works
Sayegh, F. J. P., Moulédous, L., Macri, C., Macedo, J. P., Lejards, C., Rampon, C., Verret, L., & Dahan, L. (2024) · Nature Communications · doi:10.1038/s41467-024-47481-4 · Cited by 54 · see citing works
Pu, Z., Krugers, H. J., & Joëls, M. (2009) · Learning & Memory · doi:10.1101/lm.1272409 · Cited by 47 · see citing works
Pharmacological enhancement of memory or cognition in normal subjects
Lynch, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00090 · Cited by 46 · see citing works
Ranganathan, M., DeMartinis, N. A., Huguenel, B. M., Gaudreault, F., Bednar, M. M., Shaffer, C. L., Gupta, S., Cahill, J. D., Sherif, M. A., Mancuso, J. Y., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.6 · Cited by 46 · see citing works
Lecca, D., Bader, M., Tweedie, D., Hoffman, A. F., Jung, Y. J., Hsueh, S., Hoffer, B. J., Becker, R. E., Pick, C. G., Lupica, C. R., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104528 · Cited by 45 · see citing works
Somatostatin and Somatostatin-Containing Interneurons—From Plasticity to Pathology
Liguz‐Lecznar, M., Dobrzański, G., & Kossut, M. M. (2022) · Biomolecules · doi:10.3390/biom12020312 · Cited by 46 · see citing works
Reconsidering ‘spatial memory’ and the Morris water maze
Sullivan, J. A. (2010) · Synthese · doi:10.1007/s11229-010-9849-5 · Cited by 44 · see citing works
An, L., Yang, Z. R., & Zhang, T. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12040 · Cited by 43 · see citing works
Xiao, X., Xu, X.-X., Li, F., Xie, G.-M., & Zhang, T. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.05.017 · Cited by 42 · see citing works
An, L., & Sun, W. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.02.005 · Cited by 41 · see citing works
Izquierdo, I., Bevilaqua, L. R., Rossato, J. I., da Silva, W. C. F. N., Bonini, J. S., Medina, J. H., & Cammarota, M. (2008) · Neurotoxicity Research · doi:10.1007/bf03033816 · Cited by 40 · see citing works
A robust automated method to analyze rodent motion during fear conditioning
Kopec, C. D., Kessels, H. W. H. G., Bush, D. E. A., Cain, C. K., LeDoux, J. E., & Malinow, R. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.028 · Cited by 39 · see citing works
Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
Welsby, P. J., Rowan, M. J., & Anwyl, R. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.013 · Cited by 39 · see citing works
Sarabdjitsingh, R. A., Kofink, D., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042143 · Cited by 39 · see citing works
Billa, S. K., Sinha, N., Rudrabhatla, S. R., & Morón, J. A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06560.x · Cited by 38 · see citing works
Non-ionotropic signaling by the NMDA receptor: controversy and opportunity
Gray, J. A., Zito, K., & Hell, J. W. (2016) · F1000Research · doi:10.12688/f1000research.8366.1 · Cited by 37 · see citing works
Parallels between spacing effects during behavioral and cellular learning
Kornmeier, J., & Sosic-Vasic, Z. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00203 · Cited by 37 · see citing works
Adav, S. S., Qian, J., Ang, Y. L., Kalaria, R. N., Lai, M. K. P., Chen, C., & Sze, S. K. (2014) · Journal of Proteome Research · doi:10.1021/pr500754j · Cited by 36 · see citing works
Briones, T. L., & Darwish, H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.064 · Cited by 36 · see citing works
RetractedBriones, T. L., Woods, J., & Wadowska, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-13 · Cited by 35 · see citing works
RetractedReuillon, T. D., Ward, S. E., & Beswick, P. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160627114507 · Cited by 33 · see citing works
Cai, Y., Gavornik, J. P., Cooper, L. N., Yeung, L. C., & Shouval, H. Z. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00895.2006 · Cited by 33 · see citing works
Fernández‐Ruiz, A., Makarov, V. A., & Herreras, Ó. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00071 · Cited by 32 · see citing works
- Authors
- Morris, R. G. M.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Morris, Richard G. M.
- Venue
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2003-04-29
- Volume
- 358
- Issue
- 1432
- Pages
- 643-647
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC1693171
- OpenAlex
- W2122387933
- Cited by
- 232
- References
- 30
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 4 · 2022: 10 · 2021: 6 · 2020: 9 · 2019: 12 · 2018: 7 · 2017: 14 · 2016: 8 · 2015: 17 · 2014: 20 · 2013: 16 · 2012: 11
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Keywords
- long-term potentiation, memory, synaptic plasticity, neuroscience of learning, history of neuroscience, multiple memory systems, water maze, LTP induction
- MeSH terms
- Animals, Europe, Humans, Memory, Neurophysiology, Long-Term Potentiation, History, 20th Century
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