A complex interplay between Akt, TSC2 and the two mTOR complexes
Cited by (723)
Items 601–700 of 723
- Clinical Impact of mTOR Inhibitors on the Management of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis ComplexDarcy A. Krueger · 2011 · International Journal of Clinical Reviews
- Non-Protein Kinases as Therapeutic TargetsJeroen C. Verheijen, David J. Richard, Arie Zask · 2011 · Royal Society of Chemistry eBooks
- Mutant p53 Located in the Cytoplasm Inhibits AutophagyMaría Paz Hernández‐Cáceres, Carolina Oses, Daniel Peña, Alfredo Criollo, Eugenia Morselli · 2016 · Elsevier eBooks
- Proliferation and Differentiation Programs of Developing B CellsMarkus Werner, Hassan Jumaa · 2014 · Elsevier eBooks
- Involvement of the PI3K/Akt/mTOR Pathway in Controlling Chondrogenic Differentiation of Endometrial Mesenchymal Stromal CellsA. S. Brovkina, Roman E. Ushakov, Irina O. Vassilieva, Alisa P. Domnina, Elena Burova · 2022 · Cell and Tissue Biology
- Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcomaNatalie Geyer · 2018 · eDiss (Georg-August-Universität Göttingen)
- Critical role for the TGF-β1/mTORC1 signalling axis in defining the transcriptional identity of CTHRC1 + pathologic fibroblastsJo-Anne A M Wilson, Rachel Walters, Delphine Guillotin, Naftali Kaminski, Silvia Parolo, Manuela Platé, Rachel Clare Chambers · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- An Evidence-Based Update on the Potential Association between Rheumatoid Arthritis and LymphangioleiomyomatosisNicoleta Anamaria Paşcalău, Andrei-Flavius Radu, Carmen Delia Nistor-Cseppento, Felicia Liana Andronie-Cioară, Anamaria Jurcău, Călin Moş, Alexa Florina Bungău, SIMONA GABRIELA BUNGAU · 2023 · Journal of Personalized Medicine
- Spatial gene expression profiling reveals the distinct microenvironment of tuberous sclerosis complex-associated angiomyolipomaRyuta Watanabe, Tetsuya Fukumoto, Noriyoshi Miura, Mie Kurata, Riko Kitazawa, Tadahiko Kikugawa, Takashi Saika · 2025 · Scientific Reports
- Cross-species insights into placental evolution and diseases at the single-cell resolutionGuanghui Tan, Ao Zhang, Xuesha Cao, Jingyu Yang, Youjie Cui, Fei Wang, Tao Shi, Hengkuan Li, Haoping Wang, Huiquan Shan et al. · 2026 · Nature Communications
- Mechanisms of resistance to BTK inhibitors in B cell malignancies and emerging targeted strategiesQinyu Ni, Lixin Rui · 2026 · Molecular Therapy Oncology
- Critical role for the TGF-β1/mTORC1 signaling axis in defining the transcriptional identity of CTHRC1 + pathologic fibroblastsJo-Anne A M Wilson, Rachel Walters, Greg Contento, Madeleine Rossanese, Delphine Guillotin, Alexander I. Ward, Robert E. Hynds, Mariam Jamal‐Hanjani, Naftali Kaminski, Silvia Parolo et al. · 2026 · Science Advances
- Response to Comment on “A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation”: Building a Model of the mTOR Signaling Network with a Potentially Faulty ToolPiero Dalle Pezze, Annika Sonntag, Daryl P. Shanley, Kathrin Thedieck · 2012 · Science Signaling
- Lhermitte-Duclos DiseaseJesse Lee Kresak, Steven N. Roper, Anthony T. Yachnis · 2013 · Pathology Case Reviews
- Molecular Mechanisms of Gastrointestinal SignalingMenizibeya Osain Welcome · 2018 · Springer eBooks
- Molecular dynamics of autophagy in cancer metabolismRitu Pandey, Jagat R. Kanwar, Dhruv Kumar, Vikas K Gupta, Ashok Kumar · 2022 · Elsevier eBooks
- A Comprehensive Review on Molecular Mechanisms, Treatments, and Brief Role of Natural Products in Hepatocellular CancerLinlin Jiang, Qin Meng, Lixiu Liu, Weihang Li · 2024 · Natural Product Communications
- The PI3K-mTOR PathwayHala Elnakat Thomas, Sónia R. Veiga, George Thomas, Sara C. Kozma · 2015 · Springer eBooks
- Small Molecule–Mediated Simultaneous Induction of Apoptosis and AutophagySudhakar Jinka, Rintu Banerjee · 2017 · Elsevier eBooks
- Chromosomal Instability and Evolution of Transformed Phenotype in Cell Lines Selected from Senescent Rat Embryonic Fibroblasts with RapamycinNatalia M. Yartseva, Tatiana V. Bykova, Svetlana G. Zubova, В. А. Поспелов, Tatiana V. Pospelova · 2019 · Cell and Tissue Biology
- Tuberous Sclerosis Complex and the Mammalian Target of Rapamycin PathwaysJane J. Yu · 2010 · Wiley eBooks
- Mechanisms of resistance to lapatinib in HER2 positive breast cancerMartina S.J. McDermott · 2012 · Arrow@dit (Dublin Institute of Technology)
- Mammalian Target of RapamycinCarmel M. McNicholas, Kathleen H. Berecek · 2009 · Hypertension
- Anoikis Regulation: Complexities, Distinctions, and Cell DifferentiationMarco Beauséjour, Ariane Boutin, Pierre H. Vachon · 2018 · Wiley eBooks
- Analysis of MTORC2 in regulating aging, metabolism and cardiac disease in Drosophila melanogasterKai Chang · 2020 · Iowa State University Digital Repository (Iowa State University)
- mTORC1 Signaling Pathway Mediated SIRT6 Overexpression in TGF-β1-Induced Pulmonary FibrosisJi Zhang, Yi Ping Hu, Huiping Huang, Qun Liu, Yang Du, Guangdong Wang, Dehong Gao, Weixi Guo, Zhanxiang Wang, Aiping Ma · 2021 · Research Square
- Metabolic Regulation of Antiviral Immune Responses in MacrophagesDuale Ahmed · 2021 · Carleton University's Institutional Repository (MacOdrum Library, Carleton University)
- Circadian clocks and cancer : The implication of BMAL1 (brain and muscle Arnt-like protein-1) in colorectal and breast carcinoma development and treatmentYuan Zhang · 2019 · theses.fr (ABES)
- Stem Cells Signaling Pathways in the HeartJosé Marín-García · 2011 · Springer eBooks
- Myeloproliferative neoplasia : more insight in the pathogenesisSuzanne M. Koopmans · 2014
- PI3K Signaling and miRNA Regulation in Autism Spectrum DisordersShowming Kwok, Nikolaos Mellios, Mriganka Sur · 2012 · Elsevier eBooks
- Regulation of peripheral nerve regeneration by the mTOR pathwayAbe, Namiko · 2010 · Open Scholarship Institutional Repository (Washington University in St. Louis)
- Natural products AKTing on signal transduction pathways-molecules and methodsSabine Kiefer · 2009 · edoc (University of Basel)
- CHARACTERIZATION AND TREATMENT OF A NOVEL MOUSE MODEL OF TSC-ASSOCIATED AUTISMR. Michelle Reith · 2012 · Digital Commons-TMC (Texas Medical Center)
- Targeting the mTOR signalling pathway for prevention and therapy of tuberous sclerosis in mouse modelsMaria Kalogerou · 2013 · ORCA Online Research @Cardiff (Cardiff University)
- Unraveling the molecular and cellular mechanisms of neurological dysfunction in Tuberous Sclerosis ComplexSusan M. I. Goorden · 2012 · EUR Research Repository (Erasmus University Rotterdam)
- Systems Biology of Glioblastoma MultiformeCaroline A. Agha, Hannah C. Machemehl, Hassan M. Fathallah‐Shaykh · 2015 · InTech eBooks
- Co-Transcriptional Splicing and Functional Role of PKCβ in Insulin-Sensitive L6 Skeletal Muscle Cells and 3T3-L1 AdipocytesEden Kleiman · 2009 · Digital Commons - University of South Florida (University of South Florida)
- Therapeutics against Cancer Stem Cells: Targeting the Root of CancerKristen M. Smith, Catriona H. M. Jamieson · 2013 · Wiley-VCH eBooks
- Intrinsic Mechanisms that Regulate T Cell Homeostasis and FunctionThomas O’Brien · 2011 · DukeSpace (Duke University)
- The role of Src kinase in renal cell carcinomaTahir Qayyum · 2014 · Enlighten: Theses (The University of Glasgow)
- TSC1/TSC2 Signaling in Pancreatic β-CellsErnesto Bernal‐Mizrachi · 2010 · The Open Endocrinology Journal
- The Role of Human Insulin Growth Factor (Igf) – Axis in CarcinogenesisWojciech Michał Kwaśniewski, J Kotarski, Grzegorz Polak, Anna Goździcka‐Józefiak, Jan Kotarski · 2014 · Postepy Biologii Komorki
- Metformin: a pharmacological approach integrating hyperinsulinemia breast cáncer at the molecular, cellular clinical levelsBegoña Martı́n-Castillo, Alejandro Vázquez‐Martín, Cristina Oliveras‐Ferraros, Javier Abel Menéndez · 2010 · Avances en Diabetología
- WITHDRAWN: Mammalian target of rapamycin (mTOR) inhibition in polycystic kidney disease (PKD): From bench to bedsideHyun‐Jung Kim, Charles L. Edelstein · 2012 · Kidney Research and Clinical Practice
- Skin Diseases-Related Enzymes: Mechanisms and Clinical ApplicationsYong‐Doo Park, Jun‐Mo Yang, Zhi-Rong Lü · 2011 · Enzyme Research
- Signaling pathways in the development of female germ cellsDeepak Adhikari · 2014 · DiVA at Umeå University (Umeå University)
- The p53 homolog p63 modulates acute and chronic damage in irradiated salivary glandsGeoffrey C. Mitchell · 2010 · UA Campus Repository (The University of Arizona)
- cAMP-Regulated Cell Proliferation in Brown PreadipocytesYanling Wang · 2013 · DiVA (Stockholm University)
- mTOR, la cible fonctionnelle rapamycineLouis-André Julien, Philippe P. Roux · 2010
- Obesity dyslipidemia: the effect of central nervous system neuropeptide Y on hepatic lipoprotein metabolismJennifer M. Rojas · 2013
- The pro-survival effects of glucose-dependent insulinotropic polypeptide receptor signalling on beta cellsScott B. Widenmaier · 2010 · cIRcle (University of British Columbia)
- Identification and functional studies of two novel serine phosphorylation sites of insulin receptor substrate (IRS)-2: Ser 675 and Ser 907Fakultät Naturwissenschaften · 2010
- Defining the role of folliculin and its interacting partnersSara Seifan · 2016 · ORCA Online Research @Cardiff (Cardiff University)
- Exploiting Cancer Cell Signaling and Metabolism: Implications for Therapeutic ApproachSuman Mukhopadhyay · 2015 · CUNY Academic Works (City University of New York)
- The role of mammalian target of rapamycin (mTOR) in macrophage polarizationVanessa Byles · 2013 · OpenBU (Boston University)
- Cdc37Malathi Narayan, Umesh K. Jinwal · 2016 · Elsevier eBooks
- mTOR Signalling, Nutrients and DiseaseDeborah C. I. Goberdhan, Robert S. Boyd, Richard F. Lamb · 2008
- Combination Therapies Targeting the PI3K/AKT/mTOR PathwaysAung Naing, Gordon Brent Mills, Funda Meric‐Bernstam · 2016 · Cancer drug discovery and develogment/Cancer drug discovery and development
- Os produtos dos genes Tsc1 e Tsc2 em processos neurodegenerativosDeborah Azzi Nogueira · 2017 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- The Dissection of Signaling Cascades in Neural Stem Cell Proliferation & GBM PromotionYael N. Kusne · 2014
- Phakomatoses and Their Tumors: Genetics and New Treatment OptionsMuhammad Taimur Malik, Mohammed Faraz Majeed, Scott Turner · 2017 · InTech eBooks
- Intracellular Pathways Associated with the Etiology of AutismAnthony J. Russo · 2017 · InTech eBooks
- Macroautophagy Modulates Synaptic Function in the StriatumCiara A. Torres · 2014
- Kinaza Akt: kluczowy regulator metabolizmu i progresji nowotworów* Akt kinase: a key regulator of metabolism and progression of tumorsKatedra Cytobiochemii Uniwersytetu · 2010
- Deciphering the Role of FXR1 in Cardiac HypertrophyParth M. Patel · 2017 · UA Campus Repository (The University of Arizona)
- RNAi-based anti-cancer strategies - targeting the proto-oncogene PIM1 and oncogenic miRNAsMaren Thomas · 2013 · open_UMR Marburg DSpace 10.0 (Philipps-Universität Marburg)
- ИЗМЕНЕНИЯ КАРИОТИПА И ПРИЗНАКОВ ТРАНСФОРМИРОВАННОГО ФЕНОТИПА КЛЕТОЧНЫХ ЛИНИЙ КРЫСЫ, СЕЛЕКТИРОВАННЫХ С ПОМОЩЬЮ ИНГИБИТОРА mTOR-КИНАЗЫ РАПАМИЦИНА, "Цитология"Natalia M. Yartseva, Tatiana V. Bykova, Svetlana G. Zubova, В. А. Поспелов, Tatiana V. Pospelova · 2018 · Tsitologiya
- iMALDI as a tool to improve patient stratification for targeted cancer therapiesRobert Popp · 2018 · UVic’s Research and Learning Repository (University of Victoria)
- Importância do complexo 2 da via mTOR (mTORC2) nas funções efetoras e no metabolismo dos neutrófilos em modelo experimental de SEPSECristiane Naffah de Souza Breda · 2019 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Redox Regulation of Protein Kinase B/Akt Function by an Allosteric Disulphide BondReichelle X. Yeo · 2019 · The Sydney eScholarship Repository (The University of Sydney)
- Oogenesis Signaling from Development to Environmental Plasticity and AgingBruno Marques, Ricardo Matos, Rui Gonçalo Martinho · 2020 · Springer eBooks
- INSULIN RESISTANCE RELATED SIGNALING PATHWAYS IN THE LIVERYu‐Chun Wang · 2020
- High-throughput small RNA and transcriptome sequencing reveal reproduction-related microRNAs and mRNA in ovary of Geese in Counter-Season ProductionJinshan Ran, Lingqian Yin, Jingjing Li, Yanqiang Tang, Jian Jun Huang, Peng Ren, Xian-Xian Zhang, Zhi-Qiang Li, Siming Li, Yiping Liu · 2019
- Activated mTORC1-SIRT6 Mediates Myofibroblast Differentiation and Idiopathic Pulmonary FibrosisJi Zhang, Yi Hu, Huiping Huang, Qun Liu, Yang Du, Guangdong Wang, Dehong Gao, Weixi Guo, Zhanxiang Wang, Aiping Ma · 2021 · Research Square
- The conductors of the metabolic orchestraTomas Koltai, Stephan J. Reshkin, Fátima Baltazar, Larry Fliegel · 2021 · Elsevier eBooks
- Repression of PHLPP by miR-190 Contributes to Arsenic-Induced Akt Activation and CarcinogenesisKevin Beezhold · 2011
- Prospective Advances in Exercise-Induced Autophagy on HealthJiling Liang, Michael Kirberger, Ning Chen · 2021 · Springer eBooks
- Faculty Opinions recommendation of PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.Pascale G. Charest · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Gemcitabine-Resistance Reversion of Cucurmosin in Human Pancreatic Cancer CellsCongfei Wang, Mingjuan Fu, Heguang Huang, Jieming Xie · 2021 · Research Square
- Spliceosomic dysregulation unveils NOVA1 as an actionable therapeutic target in pancreatic neuroendocrine tumorsSergio Pedraza‐Arévalo, Emilia Alors‐Pérez, Ricardo Blázquez‐Encinas, Aura Dulcinea Herrera-Martínez, Juan M. Jiménez‐Vacas, Antonio C. Fuentes-Fayos, Óscar Reyes, Sebastián Ventura, Rafael Sánchez‐Sánchez, Rosa M. Ortega-Salas et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- The acyltransferase lycat controls specific phosphoinositides and related membrane traffic and hormone receptor signalingLeslie N. Bone · 2021
- Less is MTOR: Regulation of Protein Synthesis via the Insulin Signaling Pathway in the Anoxia-Tolerant Red-Eared Slider Trachemys Scripta ElegansKama E. Szereszewski · 2014 · Carleton University's Institutional Repository (MacOdrum Library, Carleton University)
- Intracellular MessengersGerhard Meisenberg, William H. Simmons · 2012 · Elsevier eBooks
- mGluR5 Modulation as a Treatment for Parkinson’s DiseaseKyle Farmer · 2018 · Carleton University's Institutional Repository (MacOdrum Library, Carleton University)
- The acyltransferase lycat controls specific phosphoinositides and related membrane traffic and hormone receptor signalingLeslie N. Bone · 2021
- Pulmonary Fibrosis: One Manifestation, Various DiseasesBarbara Ruaro, Marco Matucci‐Cerinic, Elisa Baratella, Marco Confalonieri, Francesco Salton, Michael Hughes · 2022 · Frontiers research topics
- Retinol/Vitamin A Signaling and Self-renewal of Embryonic Stem CellsJaspal Singh Khillan, Himanshu Bhatia, Liguo Chen · 2012 · Royal Society of Chemistry eBooks
- ULK1/2 Inhibitor: Essential Component of Autophagic Cell Death MachineryParin Salim Sidat, Malleshappa N. Noolvi, Rahul Patil, Sanket Rathod · 2022 · Journal of Pharmaceutical Research
- Data from Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3′ Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical ModelsCarol Lynn O'Brien, Jeffrey J. Wallin, Deepak Sampath, Debraj GuhaThakurta, Heidi M. Savage, Elizabeth A. Punnoose, Jane Guan, Leanne Berry, Wei Wei Prior, Lukas C. Amler et al. · 2023
- Data from Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3′ Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical ModelsCarol Lynn O'Brien, Jeffrey J. Wallin, Deepak Sampath, Debraj GuhaThakurta, Heidi M. Savage, Elizabeth A. Punnoose, Jane Guan, Leanne Berry, Wei Wei Prior, Lukas C. Amler et al. · 2023
- Everolimus Prevents Doxorubicin-Induced Apoptosis Through Autophagy, Mitophagy and AKT Activation in H9c2 CardiomyocytesSyu‐ichi Kanno, Akiyoshi Hara · 2023 · Research Square
- Extracts from Cnidium monnieri (L.) Cusson Induces Apoptosis and G1 Cell Cycle Arrest through Reducing COX-2 Expression by Regulating the Akt/GSK-3β Signaling PathwaysEun Gyeong Lim, Young-Mi Youk, Young Min Kim · 2023 · KSBB Journal
- Novel Regulatory Mechanisms Of Protein Kinase B On Apoptosis Susceptibility And Cancer DedifferentiationArnatchai Maiuthed, Pithi Chanvorachote, Regine Schneider-Stock, Jutta Eichler · 2018
- Molecular pathogenesis of T-lymphoblastic lymphomaV. R. Dneprovskii, A. S. Fedorova, Д. С. Абрамов, Egor Volchkov, Natalia V. Myakova · 2024 · Pediatric Hematology/Oncology and Immunopathology
- Nanomedicine and epigenome: Possible health risks, benefits, and future perspectivesNitin Verma, Komal Thapa, Neha Kanojia, Parul Sood, Jatin Kumar, Kamal Dua · 2024 · Elsevier eBooks
- A bioprinting approach for high-throughput production of micropatterned neuroepithelial tissues and modeling TSC2-deficient brain malformationsNegin Imani Farahani, Kenneth Kin Lam Wong, George Allen, Abhimanyu Minhas, Lisa D. Lin, Shama Nazir, Lisa M. Julian · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- A Bioprinting Approach for High-Throughput Production of Micropatterned Neuroepithelial Tissues And Modeling TSC2-Deficient Brain MalformationsNegin Imani Farahani, Kenneth Kin Lam Wong, George Allen, Abhimanyu Minhas, Lisa D. Lin, Shama Nazir, Lisa M. Julian · 2025 · SSRN Electronic Journal
- Additional file 1 of Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functionsEnrique Navas-Pérez, Vicente-García, Cristina, Serena Mirra, Demián Burguera, Noèlia Fernàndez‐Castillo, Ferrán, José Luis, Macarena López-Mayorga, Marta Alaiz-Noya, Irene Suárez‐Pereira, Ester Antón-Galindo et al. · 2020 · Figshare
- Role of p62/SQSTM1 in Statin Mediated Toxicity in Muscle CellsMridula Ramesh · 2014 · CSUN ScholarWorks (California State University, Northridge)