Manning, Brendan D.

AKT/PKB signaling: navigating downstream

Manning, B. D., & Cantley, L. C. (2007) · Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 6,115

AKT/PKB Signaling: Navigating the Network

Manning, B. D., & Toker, A. (2017) · Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 3,772

The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

Hoxhaj, G., & Manning, B. D. (2020) · Nature Reviews Cancer

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 2,137

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 2,020

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 1,555

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 1,384

Targeting the PI3K-Akt pathway in human cancer

Luo, J., Manning, B. D., & Cantley, L. C. (2003) · Cancer Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,290

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

Huang, J., & Manning, B. D. (2008) · Biochemical Journal

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 1,237

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C., & Blenis, J. (2002) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 827

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., & Manning, B. D. (2016) · Science

Biochemical and Molecular ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 795

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Dowdle, W. E., Nyfeler, B., Nagel, J., Elling, R. A., Liu, S., Triantafellow, E., Menon, S., Wang, Z., Honda, A., Pardee, G., et al. (2014) · Nature Cell Biology

Autophagy in Disease and TherapyIron Metabolism and Disorders

Cited by 759

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

Ben-Sahra, I., Howell, J. J., Asara, J. M., & Manning, B. D. (2013) · Science

Biochemical and Molecular ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 739

A complex interplay between Akt, TSC2 and the two mTOR complexes

Huang, J., & Manning, B. D. (2009) · Biochemical Society Transactions

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 724

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Dibble, C. C., Elis, W., Menon, S., Qin, W., Klekota, J., Asara, J. M., Finan, P. M., Kwiatkowski, D. J., Murphy, L. O., & Manning, B. D. (2012) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 612

Metformin Inhibits Hepatic Mtorc1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex

Howell, J. J., Hellberg, K., Turner, M., Talbott, G., Kolar, M. J., Ross, D. S., Hoxhaj, G., Saghatelian, A., Shaw, R. J., & Manning, B. D. (2017) · Cell Metabolism

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 408

Coordinated regulation of protein synthesis and degradation by mTORC1

Zhang, Y., Nicholatos, J., Dreier, J. R., Ricoult, S. J. H., Widenmaier, S. B., Hotamisligil, G. S., Kwiatkowski, D. J., & Manning, B. D. (2014) · Nature

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 350

Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors

De Raedt, T., Walton, Z., Yecies, J. L., Li, D., Chen, Y., Malone, C. F., Maertens, O., Jeong, S. M., Bronson, R. T., Lebleu, V., et al. (2011) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingEndoplasmic Reticulum Stress and Disease

Cited by 258

mTOR links oncogenic signaling to tumor cell metabolism

Yecies, J. L., & Manning, B. D. (2011) · Journal of Molecular Medicine

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 183

mTORC1 signaling activates NRF1 to increase cellular proteasome levels

Zhang, Y., & Manning, B. D. (2015) · Cell Cycle

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 85