Cited by 724PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex ResearchMetabolism, Diabetes, and Cancer

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A complex interplay between Akt, TSC2 and the two mTOR complexes

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Huang, Jingxiang, Manning, Brendan D.·2009·Biochemical Society Transactions

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Abstract

Akt/PKB (protein kinase B) both regulates and is regulated by the TSC (tuberous sclerosis complex) 1–TSC2 complex. Downstream of PI3K (phosphoinositide 3-kinase), Akt phosphorylates TSC2 directly on multiple sites. Although the molecular mechanism is not well understood, these phosphorylation events relieve the inhibitory effects of the TSC1–TSC2 complex on Rheb and mTORC1 [mTOR (mammalian target of rapamycin) complex] 1, thereby activating mTORC1 in response to growth factors. Through negative-feedback mechanisms, mTORC1 activity inhibits growth factor stimulation of PI3K. This is particularly evident in cells and tumours lacking the TSC1–TSC2 complex, where Akt signalling is severely attenuated due, at least in part, to constitutive activation of mTORC1. An additional level of complexity in the relationship between Akt and the TSC1–TSC2 complex has recently been uncovered. The growth-factor-stimulated kinase activity of mTORC2 [also known as the mTOR–rictor (rapamycin-insensitive companion of mTOR) complex], which normally enhances Akt signalling by phosphorylating its hydrophobic motif (Ser473), was found to be defective in cells lacking the TSC1–TSC2 complex. This effect on mTORC2 can be separated from the inhibitory effects of the TSC1–TSC2 complex on Rheb and mTORC1. The present review discusses our current understanding of the increasingly complex functional interactions between Akt, the TSC1–TSC2 complex and mTOR, which are fundamentally important players in a large variety of human diseases.

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Authors: Huang, J., & Manning, B. D.
Affiliations: Harvard University (US)
Corresponding author: Manning, Brendan D.
ORCID: Huang, Jingxiang
Manning, Brendan D.
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2009-01-20
Volume: 37
Issue: 1
Pages: 217-222
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst0370217
PMC: PMC2778026
OpenAlex: W2065322400
Cited by: 724
References: 35
Citations by year: 2026: 17 · 2025: 18 · 2024: 21 · 2023: 22 · 2022: 31 · 2021: 31 · 2020: 37 · 2019: 40 · 2018: 49 · 2017: 40 · 2016: 38 · 2015: 53 · 2014: 60 · 2013: 51 · 2012: 67
FWCI: 5.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Biochemical Society Transactions (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA122617, P01CA120964)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Health Sciences › Medicine › Genetics (clinical) › Tuberous Sclerosis Complex Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: Akt, TSC1/TSC2 complex, tuberous sclerosis complex, mTORC1, mTORC2, PI3K signaling, Rheb, Akt phosphorylation, negative feedback regulation, growth factor signaling, tumor growth
MeSH terms: Tuberous Sclerosis Complex 2 Protein, Animals, Humans, Protein Kinases, Transcription Factors, Phosphatidylinositol 3-Kinases, Feedback, Physiological, Tumor Suppressor Proteins, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases

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A complex interplay between Akt, TSC2 and the two mTOR complexes

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