Cited by 166Alzheimer's disease research and treatmentsAutophagy in Disease and TherapyUbiquitin and proteasome pathways

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Degradation of tau protein by autophagy and proteasomal pathways

Wang, Yipeng, Mandelkow, Eckhard·2012·Biochemical Society Transactions

DOI 10.1042/bst20120071

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Abstract

Tau aggregates are present in several neurodegenerative diseases and correlate with the severity of memory deficit in AD (Alzheimer's disease). However, the triggers of tau aggregation and tau-induced neurodegeneration are still elusive. The impairment of protein-degradation systems might play a role in such processes, as these pathways normally keep tau levels at a low level which may prevent aggregation. Some proteases can process tau and thus contribute to tau aggregation by generating amyloidogenic fragments, but the complete clearance of tau mainly relies on the UPS (ubiquitin–proteasome system) and the ALS (autophagy–lysosome system). In the present paper, we focus on the regulation of the degradation of tau by the UPS and ALS and its relation to tau aggregation. We anticipate that stimulation of these two protein-degradation systems might be a potential therapeutic strategy for AD and other tauopathies.

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Authors: Wang, Y., & Mandelkow, E.
Affiliations: German Center for Neurodegenerative Diseases (DE)
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Corresponding author: Wang, Yipeng
ORCID: Wang, Yipeng
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2012-07-20
Volume: 40
Issue: 4
Pages: 644-652
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst20120071
OpenAlex: W2149107089
Semantic Scholar: d284a357b1c845f43f0ed4c30e07818cb0344a3c
Cited by: 166
References: 102
Citations by year: 2026: 2 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 18 · 2021: 16 · 2020: 25 · 2019: 11 · 2018: 13 · 2017: 12 · 2016: 16 · 2015: 14 · 2014: 7 · 2013: 6 · 2012: 2
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Society Transactions (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
DZNE Pub (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Wellcome Trust
Bundesministerium für Bildung und Forschung
Tau Consortium
Medical Research Council (MC_G1000734)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: tau protein, tau aggregation, protein degradation, ubiquitin-proteasome system, autophagy-lysosome system, Alzheimer's disease, tauopathy, neurodegeneration, proteolytic enzymes, therapeutic target
MeSH terms: Animals, Autophagy, Humans, Signal Transduction, tau Proteins, Proteasome Endopeptidase Complex

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Degradation of tau protein by autophagy and proteasomal pathways

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