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Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system

Lee, Min Jae, Lee, Jung Hoon, Rubinsztein, David C.·2013·Progress in Neurobiology
DOI 10.1016/j.pneurobio.2013.03.001
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Abstract

The ubiquitin-proteasome system (UPS) and the autophagy-lysosome system are two major protein quality control mechanisms in eukaryotic cells. While the UPS has been considered for decades as the critical regulator in the degradation of various aggregate-prone proteins, autophagy has more recently been shown to be an important pathway implicated in neuronal health and disease. The two hallmark lesions of Alzheimer's disease (AD) are extracellular β-amyloid plaques and intracellular tau tangles. It has been suggested that tau accumulation is pathologically more relevant to the development of neurodegeneration and cognitive decline in AD patients than β-amyloid plaques. Here, we review the UPS and autophagy-mediated tau clearance mechanisms and outline the biochemical connections between these two processes. In addition, we discuss pharmacological methods that target these degradation systems for the treatment and prevention of AD.

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Metadata

Authors
Lee, M. J., Lee, J. H., & Rubinsztein, D. C.
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2013-06
Volume
105
Pages
49-59
ISSN
0301-0082
DOI
10.1016/j.pneurobio.2013.03.001
Cited by
336
References
22
Language
en
Licence
Funders
  • Tau Consortium
  • Medical Research Council
  • Ministry of Health and Welfare (A111227)
  • National Research Foundation of Korea
  • Ministry of Education, Science and Technology (2012-0003217, 2012-0009484, 2012R1A6A3A01039788)
  • Wellcome Trust

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