Cited by 1,200Genomics, phytochemicals, and oxidative stressNF-κB Signaling PathwaysRedox biology and oxidative stress

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Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

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Wardyn, Joanna D., Ponsford, Amy H., Sanderson, Christopher M.·2015·Biochemical Society Transactions

DOI 10.1042/bst20150014PMC PMC4613495

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Abstract

In most tissues, cells are exposed to frequent changes in levels of oxidative stress and inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-κB (NF-κB) are the two key transcription factors that regulate cellular responses to oxidative stress and inflammation respectively. Pharmacological and genetic studies suggest that there is functional cross-talk between these two important pathways. The absence of Nrf2 can exacerbate NF-κB activity leading to increased cytokine production, whereas NF-κB can modulate Nrf2 transcription and activity, having both positive and negative effects on the target gene expression. This review focuses on the potentially complex molecular mechanisms that link the Nrf2 and NF-κB pathways and the importance of designing more effective therapeutic strategies to prevent or treat a broad range of neurological disorders.

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Src Subfamily Kinases Regulate Nuclear Export and Degradation of Transcription Factor Nrf2 to Switch Off Nrf2-mediated Antioxidant Activation of Cytoprotective Gene Expression
Niture, S. K., Jain, A. K., Shelton, P. M., & Jaiswal, A. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.255042 · Cited by 80
Retracted
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
Targeting the KEAP1-NRF2 system to prevent kidney disease progression
Nezu, M., Suzuki, N., & Yamamoto, M. (2017) · American Journal of Nephrology · doi:10.1159/000475890 · Cited by 3,447
Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90807-x · Cited by 1,961
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
Jain, A., Lamark, T., Sjøttem, E., Bowitz Larsen, K., Atesoh Awuh, J., Øvervatn, A., McMahon, M., Hayes, J. D., & Johansen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118976 · Cited by 1,472
Inflammation meets cancer, with NF-κB as the matchmaker
Ben‐Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,412
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
Kansanen, E., Kuosmanen, S. M., Leinonen, H., & Levonen, A.-L. (2013) · Redox Biology · doi:10.1016/j.redox.2012.10.001 · Cited by 1,313
Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.003 · Cited by 1,243
Untitled work
(2002) · PubMed · Cited by 1,190
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
Thimmulappa, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25790 · Cited by 1,028
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitroPreprint
Winston, J. T., Strack, P. R., Beer‐Romero, P., Chu, C. Y., Elledge, S. J., & Harper, J. W. (1999) · Genes & Development · doi:10.1101/gad.13.3.270 · Cited by 964
Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis
Lee, J., Calkins, M. J., Chan, K., Kan, Y. W., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211558200 · Cited by 783
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
Suh, J. H., Shenvi, S. V., Dixon, B. M., Liu, H., Jaiswal, A. K., Liu, R.-M., & Hagen, T. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400282101 · Cited by 774
SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D., & Cuadrado, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01204-10 · Cited by 759
NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
Liu, G.-H., Qu, J., & Shen, X. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.002 · Cited by 697
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A., & Hayes, J. D. (2013) · Oncogene · doi:10.1038/onc.2012.388 · Cited by 657
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Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway
Kwak, M.-K., Wakabayashi, N., Greenlaw, J. L., Yamamoto, M. P., & Kensler, T. W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8786-8794.2003 · Cited by 498
The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation
Innamorato, N. G., Rojo, A. I., García‐Yagüe, Á. J., Yamamoto, M. P., CEBALLOS, M. L. D., & Cuadrado, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.680 · Cited by 479
Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation
Soares, M. P., Seldon, M. P., Grégoire, I. P., Vassilevskaia, T. D., Berberat, P. O., Yu, J. H., Tsui, T., & Bach, F. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3553 · Cited by 464
Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy
Yerra, V. G., Negi, G., Sharma, S. S., & Kumar, A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.07.005 · Cited by 443
The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease
Calkins, M. J., Johnson, D. A., Townsend, J. A., Vargas, M. R., Dowell, J. A., Williamson, T. P., Kraft, A. D., Lee, J., Li, J., & Johnson, J. A. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2242 · Cited by 441
Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks
Hirotsu, Y., Katsuoka, F., Funayama, R., Nagashima, T., Nishida, Y., Nakayama, K., Engel, J. D., & Yamamoto, M. P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks827 · Cited by 431
Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
Sun, Z., Chin, Y. E., & Zhang, D. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01639-08 · Cited by 424
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Mauro, C., Leow, S. C., Ansó, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., Smaele, E. D., Beg, A. A., Tergaonkar, V., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2324 · Cited by 405
Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway
Sakurai, H., Suzuki, S., Kawasaki, N., Nakano, H., Okazaki, T., CHINO, A., Doi, T., & Saiki, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301598200 · Cited by 376
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Cuadrado, A., Martín‐Moldes, Z., Ye, J., & Lastres‐Becker, I. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.540633 · Cited by 330
Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
Lin, W., Wu, R. T., Wu, T., Khor, T.-O., Wang, H., & Kong, A. T. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.07.036 · Cited by 324
Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
Yu, M., Li, H., Liu, Q., Liu, F., Tang, L., Li, C., Yuan, Y., Zhan, Y., Xu, W., Li, W., et al. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.01.014 · Cited by 319
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene
Dhakshinamoorthy, S., & Jaiswal, A. K. (2001) · Oncogene · doi:10.1038/sj.onc.1204506 · Cited by 290
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance
Rushworth, S. A., Zaitseva, L., Murray, M. Y., Shah, N. M., Bowles, K. M., & MacEwan, D. J. (2012) · Blood · doi:10.1182/blood-2012-04-422121 · Cited by 290
Hierarchies of NF-κB target-gene regulation
Smale, S. T. (2011) · Nature Immunology · doi:10.1038/ni.2070 · Cited by 249
The role of GSK3 in glucose homeostasis and the development of insulin resistance
Lee, J., & Kim, M. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.01.033 · Cited by 248
Unique Function of the Nrf2–Keap1 Pathway in the Inducible Expression of Antioxidant and Detoxifying Enzymes
Kobayashi, A., Ohta, T., & Yamamoto, M. P. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)78021-0 · Cited by 243
Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation
Kim, J.-E., You, D., Lee, C., Ahn, C., Seong, J. Y., & Hwang, J. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.06.004 · Cited by 234
Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response
Jiang, T., Tian, F., Zheng, H., Whitman, S. A., Lin, Y., Zhang, Z., Zhang, N., & Zhang, D. D. (2013) · Kidney International · doi:10.1038/ki.2013.343 · Cited by 233
The p62 Scaffold Regulates Nerve Growth Factor-induced NF-κB Activation by Influencing TRAF6 Polyubiquitination
Wooten, M. W., Geetha, T., Seibenhener, M. L., Babu, J. R., Díaz-Meco, M. T., & Moscat, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500237200 · Cited by 225
Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage
Wang, B., Zhu, X., Kim, Y., Li, J., Huang, S., Saleem, S., Li, R.-C., Xu, Y., Doré, S., & Cao, W. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.006 · Cited by 224
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
Neymotin, A., Calingasan, N. Y., Wille, E. J., Naseri, N., Petri, S., Damiano, M. G., Liby, K. T., Risingsong, R., Sporn, M. B., Beal, M. F., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.027 · Cited by 212
Tumor necrosis factor induces GSK3 kinase–mediated cross-tolerance to endotoxin in macrophages
Park, S. H., Park‐Min, K., Chen, J., Hu, X., & Ivashkiv, L. B. (2011) · Nature Immunology · doi:10.1038/ni.2043 · Cited by 183
The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes
Pan, H., Wang, H., Wang, X., Zhu, L., & Mao, L. (2012) · Mediators of Inflammation · doi:10.1155/2012/217580 · Cited by 179
Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation
Danilov, C. A., Chandrasekaran, K., Racz, J. L., Soane, L., Zielke, C. L., & Fiskum, G. M. (2008) · Glia · doi:10.1002/glia.20793 · Cited by 141
Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity.
Jing, X., Shi, H., Zhang, C., Ren, M., Han, M., Wei, X.-B., Zhang, X.-M., & Lou, H. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.047 · Cited by 129
Up-down Regulation of HO-1 and iNOS Gene Expressions by Ethyl Pyruvate via Recruiting p300 to Nrf2 and Depriving It from p65
Kim, S.-W., Lee, H., Shin, J., & Lee, J.-K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.028 · Cited by 129
Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
Brandenburg, L., Kipp, M., Lucius, R., Pufe, T., & Wruck, C. J. (2009) · Inflammation Research · doi:10.1007/s00011-009-0116-5 · Cited by 126
Regulation of NADPH oxidase subunit p22phoxby NF-kB in human aortic smooth muscle cells
Manea, A., Manea, S., Gafencu, A. V., & Raicu, M. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701531235 · Cited by 114
KPNA6 (Importin α7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response
Sun, Z., Wu, T., Zhao, F. L., Lau, A., Birch, C. M., & Zhang, D. D. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05036-11 · Cited by 97
MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation
Hwang, Y.-J., Lee, E., Song, J., Kim, H.-R., Jun, Y.-C., & Hwang, K. (2013) · Scientific Reports · doi:10.1038/srep03242 · Cited by 74

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“However, the molecular mechanisms underlying this functional interaction appear to be cell type and tissue specific, and are still under elucidation [33].”
Background
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Authors: Wardyn, J. D., Ponsford, A. H., & Sanderson, C. M.
Affiliations: University of Liverpool (GB)
Corresponding author: Sanderson, Christopher M.
ORCID: Ponsford, Amy H.
Sanderson, Christopher M.
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2015-08-01
Volume: 43
Issue: 4
Pages: 621-626
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst20150014
PMC: PMC4613495
OpenAlex: W2133584350
Cited by: 1,200
References: 53
Citations by year: 2026: 139 · 2025: 131 · 2024: 117 · 2023: 145 · 2022: 165 · 2021: 154 · 2020: 124 · 2019: 95 · 2018: 68 · 2017: 44 · 2016: 15 · 2015: 1
FWCI: 4.09
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Society Transactions (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (096564/Z/11/Z)
Directorate for Biological Sciences
Biotechnology and Biological Sciences Research Council (1222890, BB/J014516/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: Nrf2, NF-κB, oxidative stress, inflammation, cytokine production, neurological disorders, treatment options
MeSH terms: Animals, Gene Expression Regulation, Humans, Nervous System Diseases, Signal Transduction, Cytokines, NF-kappa B, Oxidative Stress, NF-E2-Related Factor 2

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Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

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