The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
Open accessAbstract
In most tissues, cells are exposed to frequent changes in levels of oxidative stress and inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-κB (NF-κB) are the two key transcription factors that regulate cellular responses to oxidative stress and inflammation respectively. Pharmacological and genetic studies suggest that there is functional cross-talk between these two important pathways. The absence of Nrf2 can exacerbate NF-κB activity leading to increased cytokine production, whereas NF-κB can modulate Nrf2 transcription and activity, having both positive and negative effects on the target gene expression. This review focuses on the potentially complex molecular mechanisms that link the Nrf2 and NF-κB pathways and the importance of designing more effective therapeutic strategies to prevent or treat a broad range of neurological disorders.
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“Lack of Nrf2 activity can exacerbate NF-κB signaling, leading to increased cytokine production; alternatively, NF-κB can modulate Nrf2 activity, having both positive and negative effects on target gene expression [152, 153].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [152]
In the citing paper
“Competition of Nrf2 and NF-κB at DNA binding level is one of the anti-inflammatory mechanisms of Nrf2 (60, 61).”
From Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway (2019) · cites this paper as [60]
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Cites
1 retracted
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RetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
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Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
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Cited by
Sorted by citations
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679
Nrf2-Keap1 signaling in oxidative and reductive stress
Bellezza, I., Giambanco, I., Minelli, A., & Donato, R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.02.010 · Cited by 2,134
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
Saha, S., Buttari, B., Panieri, E., Profumo, E., & Saso, L. (2020) · Molecules · doi:10.3390/molecules25225474 · Cited by 1,460
“However, the molecular mechanisms underlying this functional interaction appear to be cell type and tissue specific, and are still under elucidation [33].”
BackgroundReactive Oxygen Species: Drivers of Physiological and Pathological Processes
Checa, J., & Aran, J. M. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s275595 · Cited by 1,068
Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
Singh, R., Chandrashekharappa, S., Bodduluri, S. R., Baby, B. V., Hegde, B., Kotla, N. G., Hiwale, A. A., Saiyed, T., Patel, P., Vijay-Kumar, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07859-7 · Cited by 713
Metadata
- Authors
- Wardyn, J. D., Ponsford, A. H., & Sanderson, C. M.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Sanderson, Christopher M.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2015-08-01
- Volume
- 43
- Issue
- 4
- Pages
- 621-626
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- PMC
- PMC4613495
- OpenAlex
- W2133584350
- Cited by
- 1,200
- References
- 53
- Citations by year
- 2026: 139 · 2025: 131 · 2024: 117 · 2023: 145 · 2022: 165 · 2021: 154 · 2020: 124 · 2019: 95 · 2018: 68 · 2017: 44 · 2016: 15 · 2015: 1
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Society Transactions (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (096564/Z/11/Z)
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council (1222890, BB/J014516/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- Nrf2, NF-κB, oxidative stress, inflammation, cytokine production, neurological disorders, treatment options
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Nervous System Diseases, Signal Transduction, Cytokines, NF-kappa B, Oxidative Stress, NF-E2-Related Factor 2
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