The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease
Open accessAbstract
In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a protein is determined by its amino acid sequence. This work laid the foundation for the sequence–structure–function paradigm, which states that the sequence of a protein determines its structure, and structure determines function. However, a class of polypeptide segments called intrinsically disordered regions does not conform to this postulate. In this review, I will first describe established and emerging ideas about how disordered regions contribute to protein function. I will then discuss molecular principles by which regulatory mechanisms, such as alternative splicing and asymmetric localization of transcripts that encode disordered regions, can increase the functional versatility of proteins. Finally, I will discuss how disordered regions contribute to human disease and the emergence of cellular complexity during organismal evolution.
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Citations
Cites
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Cited by
Boija, A., Klein, I. A., Sabari, B. R., Dall’Agnese, A., Coffey, E. L., Zamudio, A. V., Li, C. H., Shrinivas, K., Manteiga, J. C., Hannett, N. M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.042 · Cited by 1,815
Targeting intrinsically disordered proteins at the edge of chaos
Ruan, H., Sun, Q., Zhang, W., Liu, Y., & Lai, L. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2018.09.017 · Cited by 133
Predicting the pathogenicity of missense variants using features derived from AlphaFold2
Schmidt, A., Röner, S., Mai, K., Klinkhammer, H., Kircher, M., & Ludwig, K. U. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad280 · Cited by 79
Protein intrinsically disordered regions have a non-random, modular architecture
McConnell, B. S., & Parker, M. W. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad732 · Cited by 17
(2022) · doi:10.1016/j.jbc.2022.101986 · Cited by 12
Metadata
- Authors
- Babu, M. M.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2016-10-15
- Volume
- 44
- Issue
- 5
- Pages
- 1185-1200
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2535071049
- Cited by
- 415
- References
- 25
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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