The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
MSC exosome works through a protein-based mechanism of action
Open accessAbstract
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are secreted into the extracellular space when multivesicular bodies in the MSC fuse with the plasma membrane. However, the exosome is just one of several 50–200 nm extracellular vesicles (EVs) known to be secreted by cells. Nevertheless, the term ‘MSC exosome’ is often used to describe populations of 50–200 nm EVs that are prepared from culture medium conditioned by MSCs on the basis that these populations collectively exhibited typical exosome-associated proteins such as endosomal proteins, TSG101 and Alix, and tetraspanin proteins, CD9, CD63 and CD81. They also carry a rich diverse RNA cargo. MSC exosomes are increasingly implicated as the mediator of many of the MSC-associated therapeutic potencies. They elicit therapeutic activity by delivering their cargo of potentially therapeutic proteins and RNAs to the recipient cells. The therapeutic potency of MSC exosomes is usually rationalized on the presence of a biologically relevant protein or RNA in the MSC exosome. In the present paper, we expanded this rationale beyond a physical presence to include biologically relevant concentration, biochemical functionality and the potential to elicit an appropriate timely biochemical response. Based on these, we propose that MSC exosomes most probably work through the protein rather than the RNA.
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Cites
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Cited by
Exosomes: key players in cancer and potential therapeutic strategy
Dai, J., Su, Y., Zhong, S., Cong, L., Liu, B., Yang, J., Tao, Y., He, Z., Chen, C., & Jiang, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00261-0 · Cited by 1,186
Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling
Sun, X., Gao, J., Meng, X., Lu, X., Zhang, L., & Chen, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763334 · Cited by 291
Maumus, M., Rozier, P., Boulestreau, J., Jorgensen, C., & Noël, D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00997 · Cited by 203
Tan, S. H. S., Wong, J. R. Y., Sim, S. J. Y., Tjio, C. K. E., Wong, K. L., Chew, J. R. J., Hui, J. H. P., & Toh, W. S. (2020) · Materials Today Bio · doi:10.1016/j.mtbio.2020.100067 · Cited by 152
Self-citationDorronsoro, A., Santiago, F. E., Grassi, D., Zhang, T., Lai, R. C., McGowan, S. J., Angelini, L., Lavasani, M., Corbo, L., Lu, A., et al. (2021) · Aging Cell · doi:10.1111/acel.13337 · Cited by 153
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Metadata
- Authors
- Toh, W. S., Lai, R. C., Zhang, B., & Lim, S. K.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2018-07-09
- Volume
- 46
- Issue
- 4
- Pages
- 843-853
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2829474003
- Cited by
- 394
- References
- 110
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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