The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.
Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling
Open accessAbstract
Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response in the host may cause the destruction of supporting periodontal tissue. Macrophages play a variety of roles in PD, including regulatory and phagocytosis. Moreover, under the induction of different factors, macrophages polarize and form different functional phenotypes. Among them, M1-type macrophages with proinflammatory functions and M2-type macrophages with anti-inflammatory functions are the most representative, and both of them can regulate the tendency of the immune system to exert proinflammatory or anti-inflammatory functions. M1 and M2 macrophages are involved in the destructive and reparative stages of PD. Due to the complex microenvironment of PD, the dynamic development of PD, and various local mediators, increasing attention has been given to the study of macrophage polarization in PD. This review summarizes the role of macrophage polarization in the development of PD and its research progress.
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1 retracted
Albuquerque‐Souza, E., Schulte, F., Chen, T., Hardt, M., Hastürk, H., Dyke, T. E. V., Holzhausen, M., & Kantarcı, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585530 · Cited by 72
RetractedExploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · cited 1×
“During the development of inflammation, M2 antagonize the response of M1 by producing IL-4, IL-10, IL-13 and TGF-b, regulating anti-inflammatory effects and playing a role in wound healing and tissue repair (84, 85).”
BackgroundMacrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
Oral diseases: a global public health challenge
Peres, M. A., Macpherson, L. M. D., Weyant, R. J., Daly, B., Venturelli, R., Mathur, M. R., Listl, S., Celeste, R. K., Guarnizo-Herreño, C. C., Kearns, C., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31146-8 · Cited by 4,054
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Tonetti, M. S., Greenwell, H., & Kornman, K. S. (2018) · Journal of Periodontology · doi:10.1002/jper.18-0006 · Cited by 3,239
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046 · cited 2×
“In periodontal tissue, macrophage polarization to the M1 type is primarily induced by Th1 production of IFN-g and LPSdominated microbial-related factors (6).”
Background
Cited by
Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment
Wang, Y., Li, J., Tang, M., Peng, C., Wang, G., Wang, J., Wang, X., Chang, X., Guo, J., & Gui, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114688 · Cited by 100
Li, Q., Cheng, Y., Zhang, Z., Bi, Z., Ma, X., Wei, Y., & Wei, X. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1036 · Cited by 77
Metadata
- Authors
- Sun, X., Gao, J., Meng, X., Lu, X., Zhang, L., & Chen, R.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2021-12-07
- Volume
- 12
- Pages
- 763334-763334
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W4200550387
- Cited by
- 291
- References
- 182
- FWCI
- 31.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sun, X., Gao, J., Meng, X., Lu, X., Zhang, L., & Chen, R. (2021). Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.763334
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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