Effect of aging on energy-rich phosphagens in human skeletal muscles
Abstract
1. Biopsy specimens of muscle obtained after an overnight rest from 14 men and eight women, apparently healthy subjects (age range 52-79 years), were analysed for pyruvate, lactate and energy-rich phosphagens. 2. Values for metabolites showed no sex differences. Compared with previous findings in men and women about 40 years younger, the intramuscular concentrations of both total adenine nucleotides and phosphocreatine were approximately 5% lower in the elderly. Creatine was correspondingly increased, but total creatine was unchanged, as were the ATP and the ATP/ADP ratio. 3. It was concluded that energy-rich compounds showed significant but small age-related variations.
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Aging is associated with decreased levels of intramuscular creatine.
“It is well documented that aging is associated with decreased levels of intramuscular creatine [90].”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [90]
The consumption of fish contributes to increasing the intramuscular level of creatine, which has decreased.
“The consumption of fish contributes to increasing the intramuscular level of creatine, which has decreased [90].”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [90]
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- Authors
- Möller, P., Bergström, J., Fürst, P., & Hellström, K.
- Affiliations
- 1Department of Medicine, Department of Nephrology and Metabolic Research Laboratory, St Erik's Hospital, Stockholm, Sweden
- 2Department of Medicine, Department of Nephrology and Metabolic Research Laboratory, St Erik's Hospital, Stockholm, Sweden
- 3Department of Medicine, Department of Nephrology and Metabolic Research Laboratory, St Erik's Hospital, Stockholm, Sweden
- 4Department of Medicine, Department of Nephrology and Metabolic Research Laboratory, St Erik's Hospital, Stockholm, Sweden
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1980-06-01
- Volume
- 58
- Issue
- 6
- Pages
- 553-555
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2412496262
- Cited by
- 90
- References
- 0
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 5 · 2017: 1 · 2016: 6 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- aging, skeletal muscle, phosphocreatine, creatine, adenine nucleotides, ATP/ADP ratio, pyruvate, lactate, older adults, sex differences
- MeSH terms
- Adenine Nucleotides, Aged, Aging, Creatine, Energy Metabolism, Female, Humans, Lactates, Male, Middle Aged, Muscles, Phosphocreatine, Pyruvates
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