The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters
Abstract
The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry. The strongest evidence concerns epilepsy and disorders of the motor system. However, there are theoretical and experimental grounds for studying therapeutic applications in cerebral ischaemia and in chronic degenerative disorders. This review summarizes the experimental background, and proposes some key future studies.
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Cites
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413
Differential vulnerability of central neurons of the rat to quinolinic acid
Schwarcz, R., & Köhler, C. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90115-5 · Cited by 239
Cited by
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
The changing landscape of ischaemic brain injury mechanisms
Lee, J.-M., Zipfel, G. J., & Choi, D. W. (1999) · Nature · doi:10.1038/399a007 · Cited by 1,102
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
Trullas, R., & Skolnick, P. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90204-j · Cited by 785
Danysz, W., & Parsons, C. G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01382-6 · Cited by 649
Dugan, L. L., Gabrielsen, J. K., Yu, S. P., Lin, T.-S., & Choi, D. W. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0013 · Cited by 384
Metadata
- Authors
- Meldrum, B.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1985-02-01
- Volume
- 68
- Issue
- 2
- Pages
- 113-122
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2444475331
- Cited by
- 550
- References
- 2
- FWCI
- 17.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meldrum, B. (1985). Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters. Clinical Science. https://doi.org/10.1042/cs0680113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
