The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Buckminsterfullerenol Free Radical Scavengers Reduce Excitotoxic and Apoptotic Death of Cultured Cortical Neurons
Open accessAbstract
Novel anti-oxidants based on the buckminsterfullerene molecule were explored as neuroprotective agents in cortical cell cultures exposed to excitotoxic and apoptotic injuries. Two polyhydroxylated C60 derivatives, C60(OH)n, n = 12, and C60(OH)nOm, n = 18-20, m = 3-7 hemiketal groups, demonstrated excellent anti-oxidant capabilities when tested by electron paramagnetic spectroscopy with a spin-trapping agent and a hydroxyl radical-generating system. These water-soluble agents decreased excitotoxic neuronal death following brief exposure to NMDA (by 80%), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA; by 65%), or kainate (by 50%). Electrophysiology and tracer 45Ca(2+)-uptake studies verified that buckminsterfullerenois are not NMDA or AMPA/kainate receptor antagonists. Buckminsterfullerenols also reduced neuronal apoptosis induced by serum deprivation. These results support the idea that oxidative stress contributes to both excitotoxic and apoptotic neuronal death, and furthermore suggest that fullerenols represent a novel type of biological anti-oxidant compound.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Glutamate neurotoxicity and diseases of the nervous system
CHOI, D. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 7,972
Self-citationBcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X.-M., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,419
Glutamate and the pathophysiology of hypoxic–ischemic brain damage
Rothman, S. M., & Olney, J. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190202 · Cited by 2,428
Koh, J. Y., & Choi, D. W. (1987) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(87)90041-0 · Cited by 1,260
Self-citationNMDA-dependent superoxide production and neurotoxicity
Lafon-Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia
Sheardown, M. J., Nielsen, E. Ø., Hansen, A. J., Jacobsen, P., & Honoré, T. (1990) · Science · doi:10.1126/science.2154034 · Cited by 1,138
Krusic, P. J., Wasserman, E., Keizer, P. N., Morton, J. R., & Preston, K. F. (1991) · Science · doi:10.1126/science.254.5035.1183 · Cited by 925
MCGEER, E. G., & MCGEER, P. L. (1976) · Nature · doi:10.1038/263517a0 · Cited by 834
Reynolds, I., & Hastings, T. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03318.1995 · Cited by 777
Greenlund, L. J. S., Deckwerth, T. L., & Johnson, E. M. (1995) · Neuron · doi:10.1016/0896-6273(95)90287-2 · Cited by 742
Cited by
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes
Lin, Y., Ren, J., & Qu, X. (2014) · Accounts of Chemical Research · doi:10.1021/ar400250z · Cited by 1,252
Yin, J.-J., Lao, F., Fu, P. P., Wamer, W. G., Zhao, Y., Wang, P. C., Qiu, Y., Sun, B., Xing, G., Dong, J., et al. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.061 · Cited by 448
Fullerene-based antioxidants and neurodegenerative disorders.
Dugan, L. L., Lovett, E. G., Quick, K. L., Lotharius, J., Lin, T. T., & O'Malley, K. L. (2001) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(00)00064-x · Cited by 338
Self-citationNanotechnology—novel therapeutics for CNS disorders
Srikanth, M., & Kessler, J. A. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.76 · Cited by 198
Metadata
- Authors
- Dugan, L. L., Gabrielsen, J. K., Yu, S. P., Lin, T.-S., & Choi, D. W.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 3
- Issue
- 2
- Pages
- 129-135
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2060906151
- Cited by
- 384
- References
- 29
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Buckminsterfullerenol Free Radical Scavengers Reduce Excitotoxic and Apoptotic Death of Cultured Cortical Neurons. https://app.cochat.ai/papers/10.1006/nbdi.1996.0013
- The paper
- Dugan, L. L., Gabrielsen, J. K., Yu, S. P., Lin, T.-S., & Choi, D. W. (1996). Buckminsterfullerenol Free Radical Scavengers Reduce Excitotoxic and Apoptotic Death of Cultured Cortical Neurons. Neurobiology of Disease. https://doi.org/10.1006/nbdi.1996.0013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
