The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring
Open accessAbstract
Increasing maternal obesity is a challenge that has an impact on all aspects of female reproduction. Lean and obese pregnant women gain similar fat mass, but lean women store fat in the lower-body compartment and obese women in central compartments. In the non-pregnant, central storage of fat is associated with adipocyte hypertrophy and represents a failure to adequately store excess fatty acids, resulting in metabolic dysregulation and ectopic fat accumulation (lipotoxicity). Obese pregnancy is associated with exaggerated metabolic adaptation, endothelial dysfunction and increased risk of adverse pregnancy outcome. We hypothesize that the preferential storage of fat in central rather than ‘safer’ lower-body depots in obese pregnancy leads to lipotoxicity. The combination of excess fatty acids and oxidative stress leads to the production of oxidized lipids, which can be cytotoxic and influence gene expression by acting as ligands for nuclear receptors. Lipid excess and oxidative stress provoke endothelial dysfunction. Oxidized lipids can inhibit trophoblast invasion and influence placental development, lipid metabolism and transport and can also affect fetal developmental pathways. As lipotoxicity has the capability of influencing both maternal endothelial function and placental function, it may link maternal obesity and placentally related adverse pregnancy outcomes such as miscarriage and pre-eclampsia. The combination of excess/altered lipid nutrient supply, suboptimal in utero metabolic environment and alterations in placental gene expression, inflammation and metabolism may also induce obesity in the offspring.
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Pou, K. M., Massaro, J. M., Hoffmann, U., Vasan, R. S., Maurovich-Horvat, P., Larson, M. G., Keaney, J. F., Meigs, J. B., Lipinska, I., Kathiresan, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.710509 · Cited by 896
Catalano, P., & Ehrenberg, H. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00989.x · Cited by 831
Self-citationErridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776
Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta
Challier, J. C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P. M., & Hauguel-de Mouzon, S. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.010 · Cited by 712
Self-citationRole of Body Fat Distribution and the Metabolic Complications of Obesity
Jensen, M. D. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1585 · Cited by 687
Catalano, P. M., Huston, L., Amini, S. B., & Kalhan, S. C. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70662-9 · Cited by 680
Self-citationMaternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
McCurdy, C. E., Bishop, J. M., Williams, S. M., Grayson, B. E., Smith, M. S., Friedman, J. E., & Grove, K. L. (2009) · Journal of Clinical Investigation · doi:10.1172/jci32661 · Cited by 595
Study, F. T. H. A., Snijder, M. B., Visser, M., Dekker, J. M., Goodpaster, B. H., Harris, T. B., Kritchevsky, S. B., De Rekeneire, N., Kanaya, A. M., Newman, A. B., et al. (2005) · Diabetologia · doi:10.1007/s00125-004-1637-7 · Cited by 412
Obesity and Pregnancy—The Propagation of a Viscous Cycle?
Catalano, P. M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031046 · Cited by 325
Self-citationBrown, A. J., & Jessup, W. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.02.005 · Cited by 309
Cited by
The effects of oxidative stress on female reproduction: a review
Agarwal, A., Aponte-Mellado, A., Premkumar, B. J., Shaman, A., & Gupta, S. (2012) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-10-49 · Cited by 1,637
The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes Mellitus
Lappas, M., Hiden, U., Desoye, G., Froehlich, J., Mouzon, S. H.-D., & Jawerbaum, A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3765 · Cited by 442
Persson, M., Cnattingius, S., Villamor, E., Söderling, J., Pasternak, B., Stephansson, O., & Neovius, M. (2017) · BMJ · doi:10.1136/bmj.j2563 · Cited by 292
The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming
Bronson, S. L., & Bale, T. L. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.231 · Cited by 287
Catalano, P., & deMouzon, S. H. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.15 · Cited by 243
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Metadata
- Authors
- Jarvie, E., Hauguel-de-Mouzon, S., Nelson, S. M., Sattar, N., Catalano, P. M., & Freeman, D. J.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2010-04-28
- Volume
- 119
- Issue
- 3
- Pages
- 123-129
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W1973796897
- Cited by
- 258
- References
- 50
- FWCI
- 21.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jarvie, E., Hauguel-de-Mouzon, S., Nelson, S. M., Sattar, N., Catalano, P. M., & Freeman, D. J. (2010). Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. Clinical Science. https://doi.org/10.1042/cs20090640
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
