The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
Open accessAbstract
Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic diseases; however, the mechanism(s) whereby excess maternal nutrition affects fetal development remain poorly understood. Here, we investigated in nonhuman primates the effect of chronic high-fat diet (HFD) on the development of fetal metabolic systems. We found that fetal offspring from both lean and obese mothers chronically consuming a HFD had a 3-fold increase in liver triglycerides (TGs). In addition, fetal offspring from HFD-fed mothers (O-HFD) showed increased evidence of hepatic oxidative stress early in the third trimester, consistent with the development of nonalcoholic fatty liver disease (NAFLD). O-HFD animals also exhibited elevated hepatic expression of gluconeogenic enzymes and transcription factors. Furthermore, fetal glycerol levels were 2-fold higher in O-HFD animals than in control fetal offspring and correlated with maternal levels. The increased fetal hepatic TG levels persisted at P180, concurrent with a 2-fold increase in percent body fat. Importantly, reversing the maternal HFD to a low-fat diet during a subsequent pregnancy improved fetal hepatic TG levels and partially normalized gluconeogenic enzyme expression, without changing maternal body weight. These results suggest that a developing fetus is highly vulnerable to excess lipids, independent of maternal diabetes and/or obesity, and that exposure to this may increase the risk of pediatric NAFLD.
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Self-citationMaternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage
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Metadata
- Authors
- McCurdy, C. E., Bishop, J. M., Williams, S. M., Grayson, B. E., Smith, M. S., Friedman, J. E., & Grove, K. L.
- Venue
- Journal of Clinical Investigation
- Published
- 2009-01-19
- Volume
- 119
- Issue
- 2
- Pages
- 323-35
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2157422767
- Cited by
- 595
- References
- 17
- FWCI
- 31.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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