The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A translational study of circulating cell-free microRNA-1 in acute myocardial infarction
Open accessAbstract
miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding with other materials. The aim of the present translational study is to establish a method of determining the absolute amount of an miRNA in blood and to determine the potential applications of circulating cell-free miR-1 (microRNA-1) in AMI (acute myocardial infarction). The results revealed that miR-1 is the most abundant miRNA in the heart and is also a heart- and muscle-specific miRNA. In a cardiac cell necrosis model induced by Triton X-100 in vitro, we found that cardiac miR-1 can be released into the culture medium and is stable at least for 24 h. In a rat model of AMI induced by coronary ligation, we found that serum miR-1 is quickly increased after AMI with a peak at 6 h, in which an increase in miR-1 of over 200-fold was demonstrated. The miR-1 level returned to basal levels at 3 days after AMI. Moreover, the serum miR-1 level in rats with AMI had a strong positive correlation with myocardial infarct size. To verify further the relationship between myocardial size and miR-1 level, an IP (ischaemic preconditioning) model was used. The results showed that IP significantly reduced circulating miR-1 levels and myocardial infract size induced by I/R (ischaemia/reperfusion) injury. Finally, the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI.
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Cites
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Self-citationMicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4
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Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease
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Methodological challenges in utilizing mi RNA s as circulating biomarkers
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Diverse human extracellular RNAs are widely detected in human plasma
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MicroRNAs and cardiovascular diseases
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Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run
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“is increased in the bloodstream of patients with myocardial infarction (Cheng et al., 2010).”
Osaki, M., Kosaka, N., Okada, F., & Ochiya, T. (2014) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0065-0 · Cited by 13
Metadata
- Authors
- Cheng, Y., Tan, N., Yang, J., Liu, X., Cao, X., He, P., Dong, X., Qin, S., & Zhang, C.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2010-04-20
- Volume
- 119
- Issue
- 2
- Pages
- 87-95
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W1986410435
- Cited by
- 341
- References
- 7
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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