Perivascular spaces, glymphatic dysfunction, and small vessel disease

Cited by (402)

Items 201–300 of 402

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    Tohgo Kanoh, Takamasa Mizoguchi, Ayako Tonoki, Motoyuki Itoh · 2024 · Frontiers in Aging Neuroscience
  2. Brain endothelial cell activation and dysfunction associate with and contribute to the development of enlarged perivascular spaces and cerebral small vessel disease.
    Melvin Ray Hayden · 2024 · PubMed
  3. Functional abnormalities of the glymphatic system in cognitive disorders
    Wuyue Shentu, Qi Kong, Yier Zhang, Wenyao Li, Qiulu Chen, Sicheng Yan, Junjun Wang, Qi‐Lun Lai, Xu Qi, Song Qiao · 2025 · Neural Regeneration Research
  4. When sleep fails, brain clearance suffers: the role of glymphatic impairment in clinical neurology
    Alberto K. De la Herrán-Arita · 2025 · Acta Neurologica Belgica
  5. Diabetic encephalopathy: current insights and potential therapeutic strategies
    Radiy Germanovich Esin, И Х Хайруллин, Oleg Radievich Esin · 2021 · S S Korsakov Journal of Neurology and Psychiatry
  6. Prospective motion correction and automatic segmentation of penetrating arteries in phase contrast MRI at 7 T
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    Jacob Jan Sloots, Geert Jan Biessels, G Johan Amelink, Jaco J.M. Zwanenburg · 2023 · Magnetic Resonance Imaging
  8. Correlation between enlarged perivascular space and brain white matter hyperintensities in patients with recent small subcortical infarct
    Xiuli Jian, Fubiao Xu, Mi Yang, Min Zhang, Wenwei Yun · 2023 · Brain and Behavior
  9. Perivascular spaces in Alzheimer’s disease are associated with inflammatory, stress-related, and hypertension biomarkers
    Francesca Sibilia, Nasim Sheikh‐Bahaei, Wendy Jean Mack, Jeiran Choupan · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Causal relationship between inflammatory factors and cerebral small vessel disease: Univariate, multivariate, and summary‐data‐based mendelian randomization analysis
    Tianci Qiao, Haoyu Tian, Shi‐Zhe Shan, Li‐Li Shan, Zheng‐Yu Peng, Jia Ke, Mengting Li, Yang Wu, Yan Han · 2024 · Brain and Behavior
  11. Linking human cerebral and ocular waste clearance: Insights from tear fluid and ultra-high field MRI
    Merel M. van der Thiel, Nienke van de Sande, Anouk Meeusen, Gerhard S. Drenthen, Alida Annechien Postma, Rudy M.M.A. Nuijts, Noa van der Knaap, Inez H.G.B. Ramakers, Carroll A.B. Webers, Walter H. Backes et al. · 2024 · Neurobiology of Disease
  12. Impaired Flow: Glymphatic Dysfunction in Ischemic Stroke and the Influence of Sex
    Khiany Mathias, Maiara de Aguiar da Costa, Victória Linden de Rezende, Victor Duílio Antunes Maragno, Carlos Miguel Klima Felipe, Leyce da Rosa dos Reis, Cinara Ludvig Gonçalves, Fabricia Cardoso Petronilho · 2025 · Journal of Molecular Neuroscience
  13. SUR1 ‐ TRPM4 Regulates Aquaporin‐4 Subcellular Localization by Astrocytic Endfeet Calcium Signals Following Status Epilepticus
    Tingting Yang, Zhenzhou Lin, Mingjia Yu, Yongchuan Li, Jiancong Chen, Yuanchi Liu, Kaibin Huang, Suyue Pan · 2025 · Glia
  14. Association of Hypoxic-Ischemic Injury of the Brain With MRI-Derived Glymphatic Function Parameters in Neonates
    Arum Choi, Dayeon Bak, Jimin Kim, Se Won Oh, Yoonho Nam, Hyun Gi Kim · 2025 · Korean Journal of Radiology
  15. Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
    Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady V. Roshchupkin, Tim D’Aoust, Marie‐Gabrielle Duperron et al. · 2025 · Nature Aging
  16. Deep cervical lymph node analysis in central nervous system inflammatory disease
    Alexis Giff, Mattia Wruble Clark, Shamik Bhattacharyya, Peter T. Sage, Bruno Madore, Jeffrey P. Guenette, Edison K. Miyawaki · 2026 · Frontiers in Immunology
  17. Image analysis techniques for in vivo quantification of cerebrospinal fluid flow
    Dae‐Hyun Kim, Yiming Gan, Maiken Nedergaard, Douglas H. Kelley, Jeffrey Tithof · 2023 · Experiments in Fluids
  18. STAREE-Mind Imaging Study: a randomised placebo-controlled trial of atorvastatin for prevention of cerebrovascular decline and neurodegeneration in older individuals
    Ian H. Harding, Joanne L. Ryan, Stephane R. Heritier, Simone Spark, Zachary Flanagan, Richard McIntyre, Craig S. Anderson, Sharon Linda Naismith, Trevor T.‐J. Chong, Michael J O'Sullivan et al. · 2023 · BMJ Neurology Open
  19. “Glymphatic” Neurodegeneration: Is Sleep the Missing Key?
    Luigi Ferini‐Strambi, Maria Salsone · 2024 · Clinical and Translational Neuroscience
  20. Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment
    Francesca Sibilia, Nasim Sheikh‐Bahaei, Wendy Jean Mack, Giuseppe Barisano, Jeiran Choupan · 2024 · Frontiers in Cellular Neuroscience
  21. The underlying role of pericyte-related cerebral lymphatic microcirculation dysfunction in cerebral small vessel disease
    Tingting Cao, Canhong Yang, Jiafa Zhang, Yuping Yan, Zhefeng Chen, Xiaojia Peng, Chuxiang Xia, Mika Pan, Chun Zou, Tianming Lü · 2025 · Neurobiology of Disease
  22. New mechanisms of aging: From vascular to neurological system
    Qingwen Hu, F. Zhang, Hanxuan Wang, Ruixiang Wang, Dan Zhang, Rong Fu, Menglin Zhu, Hao Zhang, Meng Gu, Chunhong Shao et al. · 2025 · Brain Behavior and Immunity Integrative
  23. Antipsychotic-disease duration interaction on glymphatic function in first-episode schizophrenia: Evidence from DTI-ALPS
    Haitao Chen, Hong Xiang, Meng Zhang, Yun Dong Wen, Shiyou Tang, Shuping Tan, Jiahua Xu · 2026 · Schizophrenia Research
  24. Relationship between locus coeruleus and slow‐wave sleep in aging and Alzheimer's disease
    Neus Falgàs, Núria Tort‐Colet, Isabel Martín-Sobrino, Gerard Mayà, Marta Peña‐González, Salvatore Rudilosso, Carles Gaig, Beatríz Bosch, Aurora Arqueros, Agnès Pérez‐Millan et al. · 2026 · Alzheimer s & Dementia
  25. Sleep‐Dependent Clearance of Brain Metabolites via the Glymphatic System: Implications for Alzheimer's Pathophysiology
    Farshad Zare, Gulnora Shakhmurova, Jasur Rizaev, Aseel Smerat, Rosull Saadoon Abbood, Vinay Patil, Manoj Kumar‐Mishra · 2026 · Brain and Behavior
  26. High pulse wave velocity is associated with enlarged perivascular spaces in dementia with Lewy bodies
    Naoki Saji, Yoshino Kinjo, Kenta Murotani, Shumpei Niida, Akinori Takeda, Takashi Sakurai · 2024 · Scientific Reports
  27. Measurement of microvascular cerebral blood volume changes over the cardiac cycle with ferumoxytol‐enhanced T2* MRI
    Leonardo A. Rivera‐Rivera, Kevin M. Johnson, Patrick A. Turski, Oliver E. Wieben, Tilman B. Schubert · 2019 · Magnetic Resonance in Medicine
  28. The relevance of serum macrophage migratory inhibitory factor and cognitive dysfunction in patients with cerebral small vascular disease
    Jianhua Zhao, Xiaoting Wang, Qiong Li, Chengbiao Lu, Shaomin Li · 2023 · Frontiers in Aging Neuroscience
  29. Research and progress of focused ultrasound in the treatment of Alzheimer’s disease
    Xishun Ma, Tongxia Li, Lizhen Du, Tongliang Han · 2023 · Frontiers in Neurology
  30. Effects of one-night partial sleep deprivation on perivascular space volume fraction: Findings from the Stockholm Sleepy Brain Study
    Rachel M. Custer, Kirsten M. Lynch, Giuseppe Barisano, Megan M. Herting, Torbjörn Åkerstedt, Gustav Nilsonne, Hedyeh Ahmadi, Jeiran Choupan · 2025 · Sleep Medicine
  31. Prematurity is associated with white matter T2 MRI visible perivascular spaces in very preterm-born neonates
    Lena Meinhold, Antonio Giulio Gennari, Giancarlo Natalucci, Beatrice Latal, Flavia Maria Wehrle, Jean‐Claude Fauchère, Cornelia Franziska Hagmann, Ruth Tuura · 2025 · Brain Communications
  32. Glymphopathy and Reduced Processing Speed in Community-Dwelling Adults with Silent Cerebral Small Vessel Disease: A DTI-ALPS Study
    Zaw Myo Hein, Muhammad Faqhrul Fahmy Arbain, Muhammad Danial Che Ramli, Usman Jaffer, Che Mohd Nasril Che Mohd Nassir · 2025 · Journal of Clinical Medicine
  33. Altered glymphatic function and cerebrovascular reactivity in white matter hyperintensities: Insights into cognitive impairment
    Kai Li, Yueyan Bian, Yi Xing, Xiuqin Jia · 2025 · Brain Research Bulletin
  34. Subject of study—the aging brain
    Genrikh R. Ivanitskii, Alexei Alexandrovich Morozov · 2020 · Physics-Uspekhi
  35. Research Progress on Intracranial Lymphatic Circulation and Its Involvement in Disorders
    Fan Chen, Xuan Xie, Liang Wang · 2022 · Frontiers in Neurology
  36. Glymphatic system
    Nadezhda G. Dudchenko, Achcha Sh. Chimagomedova, Е Е Васенина, Oleg Semenovich Levin · 2022 · S S Korsakov Journal of Neurology and Psychiatry
  37. Cerebral amyloid deposition predicts long‐term cognitive decline in hemorrhagic small vessel disease
    Ya-Chin Tsai, Hsin-hsi C Tsai, Chia‐Ju Liu, Sheng-Sian Lin, Ya‐Fang Chen, Jiann‐Shing Jeng, Li‐Kai Tsai, Ruoh‐Fang Yen · 2023 · Brain and Behavior
  38. Is cerebral small vessel disease a central nervous system interstitial fluidopathy?
    Hafizah Abdul Hamid, Aqilah Hambali, Udemeobong Edet Okon, Che Mohd Nasril Che Mohd Nassir, Muhammad Zulfadli Mehat, Anwar Norazit, Muzaimi Mustapha · 2023 · IBRO Neuroscience Reports
  39. Electrical Activity During Slow-Wave Sleep and the Relationship With Enlarged Perivascular Spaces in Arteriosclerotic Cerebral Small Vessel Disease
    Miaoyi Zhang, Huan Yu, Fei Wang, Jie Tang, Na Liu, Xue Yang, Xue Ren, Langfeng Shi, Jianhui Fu · 2021 · Journal of Clinical Neurophysiology
  40. The role of arterial and venous blood flow and cerebrospinal fluid flow disturbances in the development of cognitive impairments in cerebral microangiopathy
    Лариса Анатольевна Добрынина, Bulat M. Akhmetzyanov, Zukhra Sh. Gadzhieva, Elena Igorevna Kremneva, Л А Калашникова, М. В. Кротенкова · 2019 · Annals of Clinical and Experimental Neurology
  41. Protoplasmic Perivascular Astrocytes Play a Crucial Role in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus
    Melvin Ray Hayden · 2023 · Neuroglia
  42. The involvement of perivascular spaces or tissues in the facial intradermal brain-targeted delivery
    Wei Ping Yang, Binghui Jin, Yajing Chen, Chang Cao, Jiazhen Zhu, Ying‐Zheng Zhao, Xi‐Chong Yu, Fanzhu Li · 2019 · Drug Delivery
  43. Exploring cerebral small vessel disease, choroid plexus, demographics and vascular risk factors that affect glymphatic function
    Yiwen Chen, Linfeng Yang, Meng Li, Pengcheng Liang, Zhenyu Cheng, Na Wang, Xinyue Zhang, Yu Wang, Changhu Liang, Jing Li et al. · 2025 · Japanese Journal of Radiology
  44. Alterations of neurofluid transport in patients with obstructive sleep apnea and insomnia disorder
    Masoumeh Rostampour, Daryna Apter, Ali Rostampour, Shayesteh Khosravi-Bayangani, Jorik D Elberse, Amir Sharafkhaneh, Habibolah Khazaie, Masoud Tahmasian · 2025 · Sleep Medicine
  45. Altered perivascular diffusion and elevated circulating cell-derived microparticles among individuals with enlarged perivascular spaces in subclinical cerebral small vessel disease
    Zaw Myo Hein, Che Mohd Nasril Che Mohd Nassir · 2026 · Experimental Neurology
  46. Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease
    Tat'yana S. Gulevskaya, Ануфриев Павел Лазаревич, Marine Movsesovna Tanashyan · 2022 · Annals of Clinical and Experimental Neurology
  47. Association of optic disc pallor and RNFL thickness with cerebral small vessel disease in the PREVENT‐Dementia study
    Samuel Gibbon, Audrey Low, Charlene Hamid, Megan Reid‐Schachter, Graciela Muniz Terrera, Craig William Ritchie, Emanuele Trucco, Baljean Dhillon, John Tiernan O'Brien, Tom MacGillivray · 2024 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
  48. High‐resolution MRI to noninvasively characterize drainage around the carotid artery into the cervical lymph nodes
    Zafer Keser, Garrett Smith, Emin Cagil, Fatih Tufan, Önder Albayram, Sait Albayram · 2022 · Journal of Neuroimaging
  49. Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
    Debette, Stephanie, Caro, Ilana, Western, Daniel, Namba, Shinichi, Sun, Na, Kawaguchi, Shuji, He, Yunye, Fujita, Masashi, Roshchupkin, Gennady, D'Aoust, Tim et al. · 2024
  50. Quantifying Ventricular CSF Clearance in the Human Brain Using Dynamic 18F-FDG PET: Insights into Age-Related Glymphatic Impairment
    Zeyu Zhou, Tianyun Zhao, John D. Gardus, Qiuting Wen, Feng Yang, Christine DeLorenzo, Ramin V. Parsey, Chuan Huang · 2025 · medRxiv
  51. Understanding the Connection between the Glymphatic System and Migraine: A Systematic Review
    Myoung-Jin Cha, Kyung Wook Kang, Jung-Won Shin, Hosung Kim, Jiyoung Kim · 2024 · Headache and Pain Research
  52. Chronic Intraventricular Cannulation for the Study of Glymphatic Transport
    Daniel Gahn‐Martinez, Michael J. Giannetto, Ethan Chang, Nathaniel Beam, Paul Tobin, Virginia Plá, Maiken Nedergaard · 2025 · eNeuro
  53. Diffusion along perivascular spaces as a marker for Glymphatic system impairment in spinocerebellar Ataxia type 3
    Xiao‐Yue Xia, Ziqiang Huang, Hao-Hang Lin, Zhen-Yi Liu, Lin Zhang, Mengcheng Li, Yu-Qin Tu, Na‐Ping Chen, Jun Ni, Qun-Lin Chen et al. · 2025 · Neurobiology of Disease
  54. Modulating glymphatic clearance in Alzheimer’s disease: Molecular mechanisms, imaging biomarkers, and emerging interventions
    Ghaleb Oriquat, Afaq Mahdi Ali, Pareshkumar N. Patel, Malathi Hanumanthayya, Priya Priyadarshini‐Nayak, Neeraj Bainsal, Dilbar Urazbaeva, Djumaniyazova Mukhayya Xusinovna, Alireza Ghahari · 2026 · Behavioural Brain Research
  55. Brain Lymphatic Dysfunction in Subarachnoid Hemorrhage: Pathophysiology and Clinical Implications
    Shuangyi Guo, John H. Zhang, Warren Boling, Lei Huang · 2026 · Biomolecules
  56. Unveiling the glymphatic system’s impact on neurodegenerative diseases: a comprehensive bibliometric analysis (2012–2024)
    Y. S. Wang, Qiangsheng Liu, Jang‐Yen Wu, Kun Meng, Lanting Zhou, Fan Ye · 2025 · Frontiers in Aging Neuroscience
  57. Current state of cerebral microangiopathy in hypertension
    Tat'yana S. Gulevskaya, Ануфриев Павел Лазаревич, А Н Евдокименко · 2021 · Russian Journal of Archive of Pathology
  58. Deep Medullary Vein and MRI Markers Were Related to Cerebral Hemorrhage Subtypes
    Dan Wang, Yayun Xiang, Yuling Peng, Peng Zeng, Bang Zeng, Ying Chai, Yongmei Li · 2023 · Brain Sciences
  59. Cortical microstructural involvement in cerebral small vessel disease
    Annemarie Reiländer, Marlene Engel, Ulrike Nöth, Ralf Deichmann, Manoj Shrestha, Marlies Wagner, René‐Maxime Gracien, Alexander Seiler · 2024 · Cerebral Circulation - Cognition and Behavior
  60. Investigating the role of neuroinflammation and brain clearance in frontotemporal lobar degeneration using 7T MRI and fluid biomarkers: protocol for a cross-sectional study in a tertiary care setting
    Fieke Prinse, Louise van der Weerd, John Cornelis Van Swieten, Itamar Ronen, Harro Seelaar, Lydiane Hirschler, Chloé Najac, Elise G.P. Dopper · 2025 · BMJ Open
  61. Object of study — an aging brain
    Genrikh R. Ivanitskii, Alexei Alexandrovich Morozov · 2020 · Uspekhi Fizicheskih Nauk
  62. Stroke severity mediates the effect of socioeconomic disadvantage on poor outcomes among patients with intracerebral hemorrhage
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  63. Advances in Imaging the Glymphatic System
    Jeremy N. Ford, Neel Madan, Christopher G. Filippi, Karen A Buch · 2025 · Advances in Clinical Radiology
  64. Enlarged perivascular spaces in the basal ganglia region are associated with white matter interstitial fluid content via deep medullary vein dysfunction
    Haiyuan Lan, Xinjun Lei, Qingchun Wang, Lebing Wang, Kunwang Li · 2025 · Frontiers in Human Neuroscience
  65. Unveiling potential retinal and choroidal markers with SS-OCTA in detecting cerebral small vessel disease
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  66. Altered Glymphatic Network in Spinocerebellar Ataxia: a Multimodal MRI Study Within a Structure–Environment–Function Framework
    Yang Liu, Fei Xiong, Qi Liu, Wei Wang, Tianhao Xie, Yuan Duan, Yuanliang Jiang, Jian Song · 2026 · The Cerebellum
  67. Association of MRI indexes of glymphatic system with brain atrophy and cognitive impairment in cerebral small vessel disease
    Lulu Ai, Zhiwei Li, Chaojuan Huang, Xia Zhou, Xiaoqun Zhu, Qiaoqiao Xu, Zhongwu Sun · 2026 · NeuroImage Clinical
  68. “Mind the Gap”—enlarged perivascular spaces as a potential magnetic resonance imaging biomarker of impaired glymphatic clearance in brain disorders
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  69. The Glymphatic System in Idiopathic Intracranial Hypertension
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  70. Sleep deprivation enhances amyloid beta peptide, p-tau and serotonin in the brain: Neuroprotective effects of nanowired delivery of cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and serotonin
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  71. Glymphatic Magnetic Resonance Imaging: Part II—Applications in Sleep and Neurodegenerative Diseases
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  77. Idiopathic intracranial hypertension in patients with cerebral small vessel disease: A case report
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  78. Molecular Mechanisms in Brain Metastasis
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  82. Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy
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  83. The Significance and Mechanism of Cerebral Enlarged Perivascular Space in Amyotrophic Lateral Sclerosis
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  84. Large-vessel hemodynamics are associated with glymphatic dysfunction and cognitive impairment in cerebral small vessel disease
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