Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor

Ranéia e Silva, Priscila Andrade; de Lima, Dhêmerson Souza; Mesquita Luiz, João Paulo; Câmara, Niels Olsen Saraiva; Alves-Filho, José Carlos Farias; Pontillo, Alessandra; Bortoluci, Karina Ramalho; Faquim-Mauro, Eliana L.

doi:10.1042/cs20201419

Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor

Muscle tissue damage is one of the local effects described in bothropic envenomations. Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A2 (PLA2) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome i…