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Gabapentin: pharmacology and its use in pain management
Abstract
Summary Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage‐dependent calcium ion channels at the postsynaptic dorsal horns and may, therefore, interrupt the series of events that possibly leads to the experience of a neuropathic pain sensation. Gabapentin is especially effective at relieving allodynia and hyperalgesia in animal models. It has been shown to be efficacious in numerous small clinical studies and case reports in a wide variety of pain syndromes. Gabapentin has been clearly demonstrated to be effective for the treatment of neuropathic pain in diabetic neuropathy and postherpetic neuralgia. This evidence, combined with its favourable side‐effect profile in various patient groups (including the elderly) and lack of drug interactions, makes it an attractive agent. Therefore, gabapentin should be considered an important drug in the management of neuropathic pain syndromes.
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Cited by
Scholz, J., & Woolf, C. J. (2002) · Nature Neuroscience · doi:10.1038/nn942 · Cited by 835
Morin, C. M., Drake, C. L., Harvey, A. G., Krystal, A. D., Manber, R., Riemann, D., & Spiegelhalder, K. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.26 · Cited by 746
Tiippana, E. M., Hamunen, K., Kontinen, V. K., & Kalso, E. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000261517.27532.80 · Cited by 532
Kumar, K., Kirksey, M. A., Duong, S., & Wu, C. L. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002497 · Cited by 308
Dahl, J. B., Mathiesen, O., & Møiniche, S. (2004) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2004.00484.x · Cited by 270
Metadata
- Authors
- Rose, M. A., & Kam, P. C. A.
- Venue
- Anaesthesia
- Publisher
- Wiley
- Published
- 2002-04-25
- Volume
- 57
- Issue
- 5
- Pages
- 451-462
- ISSN
- 0003-2409 (ISSN-L)
- 1365-2044
- OpenAlex
- W2010845171
- Cited by
- 535
- References
- 0
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
