The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Weight loss increases circulating levels of ghrelin in human obesity
Abstract
Summary: objective Ghrelin, a novel endogenous ligand for the GH secretagogue receptor, has been reported to have adipogenic actions and induce weight gain in addition to its GH‐releasing properties. Interestingly, recent data indicate that ghrelin is downregulated in human obesity, which is also known to be accompanied by reduced GH levels. patients and methods To investigate the influence of weight loss on circulating levels of ghrelin we recruited eight obese women among patients attending a 6‐month weight‐loss course organized by The Danish Heart Association. We measured body composition including computerized tomography as well as fasting plasma ghrelin concentrations before and after weight loss. results Plasma ghrelin concentrations increased by 12% following weight loss (P < 0·01), and the increase in ghrelin levels was positively correlated with the extent of weight loss (r = 0·68, P < 0·05). Exposure to exogenous GH intravenously did not influence fasting ghrelin levels either before or after weight loss. Our data further suggest the existence of hyperghrelinaemia in a single subject with long‐standing obesity but no signs of GH excess. conclusions This study provides evidence of a reversible suppression of ghrelin associated with obesity. The feasibility of measuring ghrelin in the circulation provides a new tool for the investigation of the complex hormonal regulation of appetite and energy balance.
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Citations
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Self-citationGhrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · cited 2×
“In rodents, subcutaneous, intracerebroventricular and intraperitoneal administration of ghrelin stimulates feeding, reduces fat utilization and increases body weight (Tschop et al. , 2000; Wren et al. , 2000; Nakazato et al. , 2001; Shintani et al. , 2001).”
BackgroundSelf-citationCirculating Ghrelin Levels Are Decreased in Human Obesity
Tschöp, M., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, E., & Heiman, M. L. (2001) · Diabetes · doi:10.2337/diabetes.50.4.707 · Cited by 2,008
The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion
Wren, A. M., Small, C. J., Ward, H. L., Murphy, K. G., Dakin, C. L., Taheri, S., Kennedy, A. R., Roberts, G. H., Morgan, D. G. A., Ghatei, M. A., et al. (2000) · Endocrinology · doi:10.1210/endo.141.11.7873 · Cited by 1,593
Ghrelin and Des-acyl Ghrelin: Two Major Forms of Rat Ghrelin Peptide in Gastrointestinal Tissue
Hosoda, H., Kojima, M., Matsuo, H., & Kangawa, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4039 · Cited by 929
Self-citationShintani, M., Ogawa, Y., Ebihara, K., Aizawa-Abe, M., Miyanaga, F., Takaya, K., Hayashi, T., Inoue, G., Hosoda, K., Kojima, M., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.2.227 · Cited by 847
Self-citationToshinai, K., Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Kojima, M., Kangawa, K., & Matsukura, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4518 · Cited by 626
Self-citationRasmussen, M. H., Hvidberg, A., Juul, A., Main, K. M., Gotfredsen, A., Skakkebaek, N. E., Hilsted, J., & Skakkebae, N. E. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7536210 · Cited by 248
RAPID COMMUNICATIONS: Mutations in the Preproghrelin/Ghrelin Gene Associated with Obesity in Humans
Ukkola, O. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.8.3996 · Cited by 211
Cited by
Ghrelin: Structure and Function
Kojima, M., & Kangawa, K. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2004 · Cited by 2,810
Self-citationTaheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477
“In one study, after 3 mo of dietary supervision, a reduction in BMI of approximately 5% was associated with a 12% increase in ghrelin and a 15% decrease in leptin [27].”
The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review
Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00270.x · Cited by 1,442
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187
Ghrelin and the short- and long-term regulation of appetite and body weight
Cummings, D. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.022 · Cited by 620
Metadata
- Authors
- Hansen, T. K., Dall, R., Hosoda, H., Kojima, M., Kangawa, K., Christiansen, J. S., & Jørgensen, J. O. L.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2002-02
- Volume
- 56
- Issue
- 2
- Pages
- 203-206
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2063052824
- Cited by
- 494
- References
- 11
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hansen, T. K., Dall, R., Hosoda, H., Kojima, M., Kangawa, K., Christiansen, J. S., & Jørgensen, J. O. L. (2002). Weight loss increases circulating levels of ghrelin in human obesity. Clinical Endocrinology. https://doi.org/10.1046/j.0300-0664.2001.01456.x
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