The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone‐marrow stromal cells
Abstract
Bone marrow stromal cells (MSCs) are multipotent stem cells that have the potential to differentiate into bone, cartilage, fat and muscle. We now demonstrate that MSCs can be induced to differentiate into cells with Schwann cell characteristics, capable of eliciting peripheral nervous system regeneration in adult rats. MSCs treated with beta‐mercaptoethanol followed by retinoic acid and cultured in the presence of forskolin, basic‐FGF, PDGF and heregulin, changed morphologically into cells resembling primary cultured Schwann cells and expressing p75, S‐100, GFAP and O4. The MSCs were genetically engineered by transduction with retrovirus encoding green fluorescent protein (GFP), and then differentiated by treatment with factors described above. They were transplanted into the cut ends of sciatic nerves, which then responded with vigorous nerve fibre regeneration within 3 weeks of the operation. Myelination of regenerated fibers by GFP‐expressing MSCs was recognized using confocal and immunoelectron microscopy. The results suggest that MSCs are able to differentiate into myelinating cells, capable of supporting nerve fibre re‐growth, and they can therefore be applied to induce nerve regeneration.
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Cited by
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Rat bone marrow mesenchymal stem cells express glial markers and stimulate nerve regeneration
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Mesenchymal stem cell transplantation in multiple sclerosis
Cohen, J. A. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.12.009 · Cited by 127
Peripheral nerve repair with cultured schwann cells: getting closer to the clinics
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Metadata
- Authors
- Dezawa, M., Takahashi, I., Esaki, M., Takano, M., & Sawada, H.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2001-12
- Volume
- 14
- Issue
- 11
- Pages
- 1771-1776
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2032281007
- Cited by
- 503
- References
- 26
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dezawa, M., Takahashi, I., Esaki, M., Takano, M., & Sawada, H. (2001). Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone‐marrow stromal cells. European Journal of Neuroscience. https://doi.org/10.1046/j.0953-816x.2001.01814.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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