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Cited by 720Mesenchymal stem cell researchExtracellular vesicles in diseasePeriodontal Regeneration and Treatments

The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

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Han, Yuyi, Yang, Jianxin, Fang, Jiankai, Zhou, Yipeng, Candi, Eleonora, Wang, Jihong, Hua, Dong, Shao, Changshun +1 more·2022·Signal Transduction and Targeted Therapy
DOI 10.1038/s41392-022-00932-0PMC PMC8935608
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Abstract

Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases.

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  • In multiple myeloma, mesenchymal stem cells from patients show altered osteogenic differentiation potential, increased secretion of pro-inflammatory cytokines such as IL-6 and CCL2, and enhanced support for tumor growth.

    “In multiple myeloma (MM), MSCs from patients show altered osteogenic differentiation potential, increased secretion of pro-inflammatory cytokines such as IL-6 and CCL2, and enhanced support for tumor growth.”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [28]

    The “Tumor-associated MSCs” passage (page unavailable) says multiple-myeloma cells can deliver exosomes to MSCs, increasing cytokine and chemokine secretion that supports tumor metastasis. It does not say these MSCs were obtained from patients, that their osteogenic differentiation was altered, or that IL-6 and CCL2 secretion increased in multiple myeloma. The passage discusses CCL2 in acute lymphoblastic leukemia instead. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • MSCs exert their therapeutic effects largely through their paracrine actions, and their communication with the inflammatory microenvironment is an essential part of this process.

    “In their research, MSCs exert their therapeutic effects largely through their paracrine actions, and their communication with the inflammatory microenvironment is an essential part of this process [3, 58, 59].”

    From Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin–angiotensin system on inflammation and oxidative stress (2024) · cites this paper as [59]

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Authors
Han, Y., Yang, J., Fang, J., Zhou, Y., Candi, E., Wang, J., Hua, D., Shao, C., & Shi, Y.
Affiliations
  • University of Rome Tor Vergata (IT)
  • Soochow University (CN)
  • Wuxi Fourth People's Hospital (CN)
Corresponding author
  • Shao, Changshun
  • Shi, Yufang
ORCID
Venue
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Published
2022-03-21
Volume
7
Issue
1
Pages
92-92
ISSN
2059-3635 (ISSN-L)
DOI
10.1038/s41392-022-00932-0
PMC
PMC8935608
OpenAlex
W4220659756
Cited by
720
References
7
Citations by year
2026: 133 · 2025: 239 · 2024: 199 · 2023: 128 · 2022: 21
FWCI
24.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (GZN1201804, 81930085, 31961133024, 32150710523, 2021YFA1100600, 2018YFA0107500)
  • Government of Jiangsu Province
  • Ministero degli Affari Esteri e della Cooperazione Internazionale
  • Soochow University (GZN1201903, GZN1201804)
  • State Key Laboratory of Radiation Medicine and Protection (GZN1201903, GZN1201804)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
mesenchymal stem cells, paracrine signaling, secretome, growth factors, cytokines, chemokines, extracellular matrix, immunomodulation, tissue regeneration, inflammatory diseases, intracellular communication
MeSH terms
Cell Differentiation, Humans, Cytokines, Mesenchymal Stem Cells

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