Cited by 186Hemoglobin structure and functionBlood properties and coagulationErythrocyte Function and Pathophysiology

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

The red blood cell as an oxygen sensor: what is the evidence?

Ellsworth, M.L.·2000·Acta Physiologica Scandinavica

DOI 10.1046/j.1365-201x.2000.00708.x

Open this paper in CoChat — free account

Abstract

The matching of oxygen supply with demand requires the existence of a mechanism within the tissue capable of both sensing tissue oxygen need and inducing alterations in vascular perfusion necessary to meet that need. Historically, localized sites within the tissue and the vessels themselves have been investigated with the sensor site failing to be determined. Within the last decade, studies have focused on the red blood cell, the efficient carrier of oxygen, as a possible candidate. The red blood cell is clearly capable of sensing oxygen levels, as its extent of haemoglobin desaturation (decrease in oxygen content) is intimately tied with tissue oxygen demand. In addition, numerous studies have indicated that the red blood cell is capable of releasing increased amounts of adenosine 5′‐triphosphate (ATP) as oxygen content falls and its haemoglobin becomes desaturated. Within the vasculature, intraluminal ATP has been shown to induce a vasodilator response which is conducted along the vessels resulting in augmentation of tissue perfusion. While details of the red blood cell’s role are still under investigation, evidence presented here supports the intriguing idea that the mobile red blood cell may itself be able to augment blood flow and oxygen delivery wherever and whenever the need might arise. Such a mechanism eliminates the requirement for a diverse network of sensing sites throughout the vasculature and should provide a more efficient means of appropriately matching oxygen supply with demand.

Integrity signals

Registry

Crossref · 10.1046/j.1365-201x.2000.00708.x

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,592
The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue
Krogh, A. (1919) · The Journal of Physiology · doi:10.1113/jphysiol.1919.sp001839 · Cited by 1,433
Purinoceptors: Are there families of P2X and P2Y purinoceptors?
Abbracchio, M. P., & Burnstock, G. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00048-4 · Cited by 1,090
Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050
Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia
Bergfeld, G. R., & Forrester, T. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.1.40 · Cited by 453
In vivo measurements of “apparent viscosity” and microvessel hematocrit in the mesentery of the cat
Lipowsky, H. H., Usami, S., & Chien, S. (1980) · Microvascular Research · doi:10.1016/0026-2862(80)90050-3 · Cited by 401
Role of shear stress and endothelial prostaglandins in flow- and viscosity-induced dilation of arterioles in vitro.
Koller, Á., Sun, D., & Kaley, G. (1993) · Circulation Research · doi:10.1161/01.res.72.6.1276 · Cited by 331
Gap Junctions in Vascular Tissues
Christ, G. J., Spray, D. C., El-Sabban, M. E., Moore, L. K., & Brink, P. R. (1996) · Circulation Research · doi:10.1161/01.res.79.4.631 · Cited by 272
Increased flow‐induced ATP release from isolated vascular endothelial cells but not smooth muscle cells
Bodin, P., Bailey, D., & Burnstock, G. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12324.x · Cited by 248

Show all 32 references

Sorted by citations

Items 101–184 of 184

Extracellular ATP activates eNOS and increases intracellular NO generation in Red Blood Cells
Ülker, P., Özen, N., Abdullayeva, G., Köksoy, S., Yaraş, N., & Basralı, F. (2017) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-170326 · Cited by 19
From Experiments to Simulation: Shear-Induced Responses of Red Blood Cells to Different Oxygen Saturation Levels
Uğurel, E., Pişkin, Ş., Aksu, A. C., Eser, A., & Yalçın, Ö. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01559 · Cited by 18
Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases
Tu, J., & Wang, L. (2009) · Neuroscience Bulletin · doi:10.1007/s12264-009-1020-2 · Cited by 17
Microcirculatory changes in children undergoing cardiac surgery: A prospective observational study
Scolletta, S., Marianello, D., Isgrò, G., Dapoto, A., Terranova, V., Franchi, F., Baryshnikova, E., Carlucci, C., & Ranucci, M. (2016) · British Journal of Anaesthesia · doi:10.1093/bja/aew187 · Cited by 17
Exercise Testing, Physical Training and Fatigue in Patients with Mitochondrial Myopathy Related to mtDNA Mutations
Jeppesen, T. D., Madsen, K. L., Poulsen, N. S., Løkken, N., & Vissing, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081796 · Cited by 16
Biomimetic O2 Self-generated hybrid membrane nanoplatform for blocking the polarization towards immunosuppressive M2 macrophage phenotype and enhancing sonodynamics therapy in orthotopic colorectal cancer
Zhang, R., Cheng, K., Sun, X., Yang, X., Li, Y., Hu, Y., Zhang, X., Liu, B., Chen, W., Zhao, Y., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138337 · Cited by 15
Vascular disease in pre-diabetes: new insights derived from systems biology.
Sprague, R. S., & Ellsworth, M. L. (2010) · Europe PMC (PubMed Central) · Cited by 15
Self-citation
The inevitability of ATP as a transmitter in the carotid body
Bardsley, E. N., Pen, D. K., McBryde, F. D., Ford, A. P. D. W., & Paton, J. F. R. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102815 · Cited by 14
Calcium-Dependent Synthesis of Prostacyclin in ATP-Stimulated Venous Endothelial Cells
Choi, J., Hammer, L. W., & Hester, R. L. (2002) · Hypertension · doi:10.1161/hy0202.103289 · Cited by 14
Red Blood Cell Transfusion in Sepsis: A Review
Sadaka, F. G. (2013) · Journal of Blood Disorders & Transfusion · doi:10.4172/2155-9864.s4-001 · Cited by 15
Absence of compensatory vasodilation with perfusion pressure challenge in exercise: evidence for and implications of the noncompensator phenotype
Bentley, R. F., Walsh, J. J., Drouin, P., Velickovic, A., Kitner, S. J., Fenuta, A. M., & Tschakovsky, M. E. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00952.2016 · Cited by 12
Recent advances in micro-sized oxygen carriers inspired by red blood cells
Zhang, Q., Inagaki, N. F., & Ito, T. (2023) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2023.2223050 · Cited by 12
Red blood cell rheology in sepsis
Piagnerelli, M., Boudjeltia, K. Z., Vanhaeverbeek, M., & Vincent, J. (2009) · Springer eBooks · doi:10.1007/978-3-642-01769-8_42 · Cited by 11
Expression of the Heterotrimeric G Protein Gi and ATP Release are Impaired in Erythrocytes of Humans with Diabetes Mellitus
Sprague, R. S., Stephenson, A. H., Bowles, E. A., Stumpf, M., Ricketts, G., & Lonigro, A. J. (2007) · Springer eBooks · doi:10.1007/978-0-387-34817-9_18 · Cited by 10
A Computational Model of a Microfluidic Device to Measure the Dynamics of Oxygen-Dependent ATP Release from Erythrocytes
Sové, R. J., Ghonaim, N., Goldman, D., & Ellis, C. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081537 · Cited by 10
Transfusion of Red Blood Cells Is Associated With Improved Central Venous Oxygen Saturation But Not Mortality in Septic Shock Patients
Sadaka (2014) · Journal of Clinical Medicine Research · doi:10.14740/jocmr1843w · Cited by 10
Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats
Yeung, P. K. F., Dauphinee, J., & Marcoux, T. (2013) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944712470297 · Cited by 10
Cerium oxide nanoparticles protect red blood cells from hyperthermia-induced damages
Liu, T., Han, S., Pang, M., Li, J., Wang, J., Luo, X. G., Wang, Y., Liu, Z., Yang, X., & Ye, Z. (2020) · Journal of Biomaterials Applications · doi:10.1177/0885328220979091 · Cited by 10
Hemodynamic regulation allows stable growth of microvascular networks
Qi, Y., Chang, S.-S., Wang, Y., Chen, C., Baek, K. I., Hsiai, T. K., & Roper, M. L. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2310993121 · Cited by 9
Overview of mathematical modeling of myocardial blood flow regulation
Namani, R., Lanir, Y., Lee, L. C., & Kassab, G. S. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00563.2019 · Cited by 9
A Study of the Effect of Isoproterenol on Red Blood Cell Concentrations of Adenine Nucleotides in a Freely Moving Rat Model In Vivo*
Yeung, P. K. F., & Seeto, D. (2013) · Cardiovascular Pharmacology Open Access · doi:10.4172/2329-6607.1000102 · Cited by 9
Characteristics and effectiveness of vasodilatory and pressor compensation for reduced relaxation time during rhythmic forearm contractions
Bentley, R. F., Poitras, V. J., Hong, T., & Tschakovsky, M. E. (2017) · Experimental Physiology · doi:10.1113/ep086069 · Cited by 8
Coronary Circulation
Tune, J. D. (2014) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00111ed1v01y201406isp054 · Cited by 8
Purinergic stimulation of carotid body efferent glossopharyngeal neurones increases intracellular Ca2+ and nitric oxide production
Lowe, M., Park, S. J., Nurse, C. A., & Campanucci, V. A. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.072058 · Cited by 8
Erythrocyte-derived epoxyeicosatrienoic acids
Jiang, H. (2006) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2006.05.013 · Cited by 8
Microcirculatory Alterations in Shock States
Hamlin, S. K., Parmley, C. L., & HANNEMAN, S. K. G. (2014) · Critical Care Nursing Clinics of North America · doi:10.1016/j.ccell.2014.04.007 · Cited by 7
Erythrocytic ATP release in the presence of modified cell-free hemoglobin
Cole, R. H., Malavalli, A., & Vandegriff, K. D. (2009) · Biophysical Chemistry · doi:10.1016/j.bpc.2009.07.004 · Cited by 7
Exercise improves hemodynamic profiles and increases red blood cell concentrations of purine nucleotides in a rodent model
Yeung, P. K. F., Dauphinee, J., Gouzoules, T., Simonson, K., & Schindler, C. (2010) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944710387809 · Cited by 7
Nitric Oxide Signaling in Health and Disease
Bryan, N. S., & Lancaster, J. R. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_11 · Cited by 7
The role of ecto-ATPases of erythrocyte plasma membrane in hemodynamics of fishes
Silkin, Y. A., & Silkina, E. N. (2017) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093017010094 · Cited by 6
Erythrocyte-derived ATP and perfusion distribution: Role of intracellular and intercellular communication
Sprague, R. S., & Ellsworth, M. L. (2012) · Microcirculation · doi:10.1111/j.1549-8719.2012.00158.x · Cited by 6
Self-citation
Nitric Oxide Signaling in Health and Disease
Bryan, N. S., & Lancaster, J. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_13 · Cited by 5
Unraveling the Gordian knot of coronary pressure-flow autoregulation
Tune, J. D., Warne, C. M., Essajee, S. I., Tucker, S. M., Figueroa, C. A., Dick, G. M., & Beard, D. A. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.04.008 · Cited by 5
Diltiazem Reduces Mortality and Breakdown of ATP in Red Blood Cell Induced by Isoproterenol in a Freely Moving Rat Model in Vivo
Yeung, P. K. F., Xu, Z., & Seeto, D. (2014) · Metabolites · doi:10.3390/metabo4030775 · Cited by 5
Microcirculatory Oxygen Transport and Utilization
Hamlin, S. K., Parmley, C. L., & HANNEMAN, S. K. G. (2014) · Critical Care Nursing Clinics of North America · doi:10.1016/j.ccell.2014.04.006 · Cited by 5
Anti-Ischemia Drugs have no Effect on the In Vivo Metabolism of ATP by RBC in Normotensive Restrained Rats#
Yeung, P. K. F., Dauphinee, J., Simonson, K., & Gouzoules, T. (2011) · The Open Drug Metabolism Journal · doi:10.2174/1874073101105010001 · Cited by 5
Solution Concentration and Flow Rate of Fe3+-modified Porphyrin (Red Blood Model) on Giant Magnetoresistance (GMR) Sensor Efficiency
Aminudin, A., Tjahyono, D. H., Suprijadi, S., Djamal, M., Zaen, R., & Nandiyanto, A. B. D. (2017) · IOP Conference Series Materials Science and Engineering · doi:10.1088/1757-899x/180/1/012137 · Cited by 5
Rho‐kinase inhibition improves haemodynamic responses and circulating ATP during hypoxia and moderate intensity handgrip exercise in healthy older adults
Racine, M. L., Terwoord, J. D., Ketelhut, N. B., Bachman, N. P., Richards, J. C., Luckasen, G. J., & Dinenno, F. A. (2022) · The Journal of Physiology · doi:10.1113/jp282730 · Cited by 5
Understanding Red Blood Cell Rheology in Sepsis and its Role in Clinical Practice. From Biomolecular Aspects to Possible Therapeutic Interventions
Moisă, E., Negoita, S. I., & Corneci, D. E. (2018) · Central European Journal of Clinical Research · doi:10.2478/cejcr-2018-0006 · Cited by 5
ATP release from erythrocytes: A role of adenosine1
Misiti, F., Carelli‐Alinovi, C., & Rodio, A. (2022) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-221379 · Cited by 5
Nucleotide Release and Purinergic Signaling in the Vasculature Driven by the Red Blood Cell
Sprague, R. S., Ellsworth, M. L., & Detrich, H. H. (2003) · Current topics in membranes · doi:10.1016/s1063-5823(03)01008-1 · Cited by 5
Self-citation
A spike in mechanotransductive adenosine triphosphate release from red blood cells in microfluidic constrictions only occurs with rare donors
Mancuso, J. E., & Ristenpart, W. D. (2018) · Microcirculation · doi:10.1111/micc.12439 · Cited by 5
An antioxidant metabolon at the red blood cell membrane
Li, B. (2009) · Spectrum Research Repository (Concordia University) · Cited by 5
Purine nucleotides reduce superoxide production by nitric oxide synthase in a murine sepsis model
Barbeiro, H. V., Barbeiro, D. F., Debbas, V., de Souza, H. P., Laurindo, F. R. M., Velasco, I. T., & Soriano, F. G. (2009) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2009005000029 · Cited by 4
A Pilot Study to Assess Adenosine 5’-triphosphate Metabolism in Red Blood Cells as a Drug Target for Potential Cardiovascular Protection
Yeung, P. K. F., Tinkel, J. L., & Seeto, D. (2016) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x15666151102102702 · Cited by 4
Adenosine linking reduced O2to arteriolar NO release in intestine is not formed from extracellular ATP
Sauls, B. A., & Boegehold, M. A. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.3.h1193 · Cited by 4
Energy Metabolism in Residents in the Low- and Moderate Altitude Regions of Central Asia with MAFLD and Type 2 Diabetes Mellitus
Toktogulova, N. A., Breidert, M., Eschbach, J., Kudaibergenova, I., Omurzakova, U., Uvaidillaeva, F., Tagaeva, B., Sultanalieva, R. B., & Eftekhari, P. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2256-6358 · Cited by 3
Commentaries on Viewpoint: A paradigm shift for local blood flow regulation
Buerk, D. G. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01360.2013 · Cited by 3
Effect of High Solid Concentration on Friction in a Transitional and Turbulent Flow of Bioliquid Suspension
Bartosik, A. S. (2023) · WSEAS TRANSACTIONS ON FLUID MECHANICS · doi:10.37394/232013.2023.18.2 · Cited by 2
Red blood cell rheology in sepsis
Piagnerelli, M., Boudjeltia, K. Z., Vanhaeverbeek, M., & Vincent, J. (2012) · Springer eBooks · doi:10.1007/978-3-642-28233-1_14 · Cited by 2
Mathematical Modelling of Oxygenation Dynamics using High-Resolution Perfusion Data – Part 1: Statistical FrameworkPreprint
Sharabiani, M. T. A., Mahani, A. S., Issitt, R. W., Srinivasan, Y., Bottle, A., & Stoica, S. C. (2024) · medRxiv · doi:10.1101/2024.03.18.24304520 · Cited by 2
Blood Flow in Microvascular Networks
Pries, A. R., & Secomb, T. W. (1984) · Comprehensive physiology · doi:10.1002/j.2040-4603.1984.tb01010.x · Cited by 1
Local Regulation of Microvascular Perfusion
Davis, M. J., Hill, M. A., & Kuo, L. (1984) · Comprehensive physiology · doi:10.1002/j.2040-4603.1984.tb01015.x · Cited by 1
A Quantitative Examination of Some Analytes Involved in the Control of Pulmonary Resistance by Employing Various Microflow Techniques and Novel Bio-Reactors
Kotsis, D. H., & Spence, D. M. (2003) · Reviews in Analytical Chemistry · doi:10.1515/revac.2003.22.4.235 · Cited by 1
31P NMR Manifestation of Metabolic Changes in Blood of Spinal Cord Injured Rats
Yurtaeva, S. V., Volkov, M. Y., Гульусовна, Я. Г., Silantyeva, D. I., & Yamalitdinova, E. I. (2018) · Applied Magnetic Resonance · doi:10.1007/s00723-018-0982-5 · Cited by 1
Sphingosine Increases ATP Release From Red Blood Cells
Misiti, F. (2022) · The Open Biochemistry Journal · doi:10.2174/1874091x-v16-e2204210 · Cited by 1
Network Analysis of Coronary Circulation: II. Pulsatile Flow
Kassab, G. S. (2019) · Springer eBooks · doi:10.1007/978-3-030-14819-5_6 · Cited by 1
Vessel Wall
Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-5966-8_7 · Cited by 1
The Critically Ill Red Blood Cell
Almac, E., & İnce, C. (2007) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-540-49433-1_72 · Cited by 1
Metabolic and hormonal blood flow modeling in patients with coronary heart disease: In vitro and clinical study
Malinova, L. I., Валентинович, С. Г., Denisova, T. P., & Tuchin, V. V. (2007) · Medical Laser Application · doi:10.1016/j.mla.2007.09.006 · Cited by 1
INFLUX AND EFFLUX OF ADENINE NUCLEOTIDES FROM ERYTHROCYTES REGULATE OXYGEN TRANSPORT AND SYSTEMIC METABOLISM
O'Brien, O., & William, G. L. (2015)
The Effect of Combined C-Peptide and Zinc on Cellular Function
Spence, D. M. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-391-2_3
RBC-ATP Theory of Regulation for Tissue Oxygenation-ATP Concentration Model
Terry, E. (2012) · InTech eBooks · doi:10.5772/48580
The Critically III Red Blood Cell
Almac, E., & İnce, C. (2007) · Springer eBooks · doi:10.1007/978-0-387-49518-7_72
Effect of terahertz irradiation of 240 GHz of nitrogen oxide occurrence on blood rheological properties
Киричук, В. Ф., Викторович, А. Е., & Паршина, С. С. (2013) · Russian Open Medical Journal · doi:10.15275/rusomj.2013.0408
Muscle Tissue Oxygenation during Nonischemic and Ischemic Isometric Handgrip Exercises
Kawahara, Y., Nakamura, Y., & Muraoka, I. (2005)
Theoretical Models of Blood Flow Regulation
Arciero, J. C. (2008) · UA Campus Repository (The University of Arizona)
Theoretical Model of Coronary Blood Flow Regulation: Role of Myocardium Compressive Forces
Xie, X., & Wang, Y. (2015) · Microcirculation · doi:10.1111/micc.12221
MODELS FOR THE STUDY OF AUTOREGULATION PHENOMENA IN THE HUMAN RETINAL MICROVASCULAR NETWORK
Sacco, R. (2011)
of Competing Physiological Needs Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy
Nickele, A., Dempsey, J. A., Babcock, M. A., Pegelow, D. F., Clausell, N., Sanches, S., Tavares, Â. M. V., Ribeiro, J. P., Berton, D. C., Balzan, F. M., et al. (2015)
The Skeletal Muscle Pump During Contractile Transitions
Ferguson, B. S. (2014)
relating erythrocyte deformation to ATP release Participation of cAMP in a signal-transduction pathway
Sprague, R. S., Ellsworth, M. L., Stephenson, A. H., & Lonigro, A. J. (2016)
Self-citation
The influence of nitric oxide and nitrite on coronary vascular resistance, platelet function and inflammation in patients undergoing revascularisation after NSTEMI and stable angina
Freeman, P. M. (2018) · ORCA Online Research @Cardiff (Cardiff University)
Physiological Roles of Nitric Oxide and Protein Disulfide Isomerase Relevant to Vascular Function
Kallakunta, V. M. (2012)
Integrated modulation of sympathetic tone in the microcirculation by oxygen, adenosine, and nitric oxide
Sauls, B. A. (2001) · doi:10.33915/etd.1409
Electrical Propagation of Vasodilatory Signals in Capillary Networks
Lee, P. (2020) · Bulletin of Mathematical Biology · doi:10.1007/s11538-020-00806-y
Red blood cell rheology in sepsis
Piagnerelli, M., Boudjeltia, K. Z., Vanhaeverbeek, M., & Vincent, J. (2007) · Springer eBooks · doi:10.1007/3-540-37363-2_35
Sphingosine Increases ATP Release From Red Blood Cells
Misiti, F. (2022) · The Open Biochemistry Journal · doi:10.2174/874091x-v16-e2204210
Retinal Blood Flow and Markers of Vascular Inflammation and Endothelial Dysfunction in Type 2 Diabetes
Khuu, L. (2010) · UWSpace (University of Waterloo)
Externalized ATP in intact erythrocyte suspensions: modulation and determination
Clarke, A. (2012) · Spectrum Research Repository (Concordia University)
Fish Red Blood Cells
Harter, T. S. (2026) · Springer eBooks · doi:10.1007/978-3-031-19369-9_49-1
Influence of the pyruvate kinase activator mitapivat (AG-348) on RBC ATP content and export and RBC adhesivity in blood from healthy subjects and sickle cell disease patients
Jagadish, A., Chen, Y., Zhu, H., Mai, W., Chow, S.-C., Li, Z., Lee, G. M., Telen, M. J., & McMahon, T. (2026) · Frontiers in Hematology · doi:10.3389/frhem.2026.1766692
Assessment of nailfold microcirculation in non-dialysis CKD: Capillaroscopic indicators correlated with renal dysfunction
Li, S., Liu, Y., Yan, H., Zhou, X., Liu, Q., Waheed, Y. A., Wang, D., & Sun, D. (2026) · PLoS ONE · doi:10.1371/journal.pone.0359419
Cardiovascular Hemodynamics During Blood Flow Restriction Exercise: A Narrative Review of Responses, Mechanisms, and Misconceptions
Mladen, S. P. S., & Tschakovsky, M. E. (2026) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000005697

Authors: Ellsworth, M. L.
Affiliations: Saint Louis University (US)
Corresponding author: Ellsworth, M.L.
Venue: Acta Physiologica Scandinavica
Publisher: Wiley
Published: 2000-04
Volume: 168
Issue: 4
Pages: 551-559
ISSN: 0001-6772 (ISSN-L)
1365-201X
DOI: 10.1046/j.1365-201x.2000.00708.x
OpenAlex: W1984179683
Cited by: 186
References: 32
Citations by year: 2026: 4 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 13 · 2012: 12
FWCI: 1.42
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 734 d)
Locations: Acta Physiologica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k04hl002602-03)
National Heart, Lung, and Blood Institute (R01HL056249, HL56249, HL 39226, HL-02602)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
Keywords: tissue oxygen demand, ATP release, vasodilation, tissue perfusion, oxygen delivery
MeSH terms: Adenosine Triphosphate, Animals, Erythrocytes, Humans, Oxygen, Oxygen Consumption, Regional Blood Flow, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The red blood cell as an oxygen sensor: what is the evidence?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks