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Characteristics of patients with irritable bowel syndrome recruited from three sources: implications for clinical trials

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Longstreth, G. F., Hawkey, C. J., Mayer, E. A., Jones, R. H., Naesdal, J., Wilson, I. K., Peacock, R. A., Wiklund, I. K.·2001·Alimentary Pharmacology & Therapeutics
DOI 10.1046/j.1365-2036.2001.01010.x
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Abstract

Background: Variation in the characteristics of irritable bowel syndrome patients recruited for clinical trials from different sources could affect their response and the generalizability of trial results. Aim: To describe and compare the characteristics of three different groups of irritable bowel syndrome patients recruited into a ‘mock clinical trial.’ Methods: We enrolled 245 irritable bowel syndrome patients from three sources: (i) 121 from British primary practitioners; (ii) 72 from California newspaper advertisements; and (iii) 52 from a California gastroenterologist’s practice. We obtained demographic, clinical, and Hospital Anxiety and Depression (HAD) Scale data. Results: Most patients were young to middle‐aged women; the majority reported symptoms for > 5 years in all three groups. Subject characteristics varied among the groups. Typically, primary care patients were anxious, smokers and daily alcohol drinkers who had sought care recently for irritable bowel syndrome and tried antispasmodic drugs. Their symptoms were intermediate in severity between those of the other two groups. Advertisement subjects were the oldest, most highly educated, most often depressed, and were least likely to have sought care recently for symptoms, which were almost uniformly only moderate in severity. Gastroenterologist patients tended to be anxious and had nearly all sought care recently for symptoms, which were the most severe and most likely to include all three pain‐related Rome I criteria. Conclusion: Recruitment methodology affects important characteristics of an irritable bowel syndrome study group.

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Metadata

Authors
Longstreth, G. F., Hawkey, C. J., Mayer, E. A., Jones, R. H., Naesdal, J., Wilson, I. K., Peacock, R. A., & Wiklund, I. K.
Affiliations
  • Kaiser Permanente (US)
  • University of Nottingham (GB)
  • University of California, Los Angeles (US)
  • King's College Hospital (GB)
  • AstraZeneca (Sweden) (SE)
Corresponding author
Longstreth, G. F.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2001-07-09
Volume
15
Issue
7
Pages
959-964
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1046/j.1365-2036.2001.01010.x
OpenAlex
W1965471884
Cited by
124
References
27
Citations by year
2026: 1 · 2023: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 13 · 2013: 6 · 2012: 6
FWCI
5.44
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 187 d)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
AstraZeneca
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
irritable bowel syndrome, patient recruitment, generalizability of trial results, primary care patients, anxiety, depression, symptom severity, Rome I criteria, smoking, alcohol consumption
MeSH terms
Adolescent, Adult, Age Factors, Aged, Alcohol Drinking, Anxiety, Clinical Trials as Topic, Colonic Diseases, Functional, Demography, Female, Humans, Male, Middle Aged, Pain, Severity of Illness Index, Sex Factors, Smoking, Reproducibility of Results, Confounding Factors, Epidemiologic, Age of Onset, Patient Selection

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