Cited by 1,384Gastrointestinal motility and disordersInfant Health and DevelopmentGut microbiota and health

AGA technical review on irritable bowel syndrome.

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Drossman, Douglas A., Camilleri, Michael, Mayer, Emeran A., Whitehead, William E.·2002·Gastroenterology

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Registry

Crossref · 10.1053/gast.2002.37095

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  • Psychological interventions such as cognitive-behavioral therapy and hypnosis are among the most successful treatments for IBS.

    “Psychological interventions such as cognitive-behavioral therapy (CBT) and hypnosis have proven among the most successful treatments for IBS (7,8).”

    From Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial (2011) · cites this paper as [8]

    The Psychological Treatment section (page unavailable) says psychological treatments are frequently helpful, and Table 8 (page unavailable) reports improvements in some CBT and hypnosis trials. But the review does not rank them among the most successful IBS treatments; it notes mixed trial results and methodological limitations, concluding that there is room for doubt. Thus, “proven among the most successful” overstates its assessment. (LLM, conf=0.88)

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  • CBT, clinical hypnosis, and brief dynamic therapy have each been shown effective for IBS in multiple studies.

    “CBT, clinical hypnosis, and brief dynamic therapy have all been shown to be effective in multiple studies (7,8).”

    From Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial (2011) · cites this paper as [8]

    Table 8 (Conclusions; page unavailable) reports favorable results from multiple CBT studies and from psychodynamic or interpersonal therapy studies. It lists only one controlled hypnosis study, with a follow-up report, rather than multiple hypnosis studies. The Psychological Treatment section also cautions that methodological limitations leave room for doubt about the positive trials. (LLM, conf=0.86)

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  • More recent population studies have suggested that earlier volunteer non-population-based studies may have been biased, but this view remains controversial.

    “In contrast, more recent population studies (42–45) have suggested that the earlier volunteer non-population-based studies may have been biased, but this view is still controversial (16).”
  • The American Gastroenterological Association technical review reported that psychiatric disorder prevalence ranges from 40% to more than 90% among IBS patients referred to tertiary care, but argued these studies overestimated true psychosocial disturbance prevalence because psychological factors influence consultation.

    “The American Gastroenterological Association technical review on IBS (16) reported that the prevalence of a psychiatric disorder ranges from 40 to more than 90% among patients with IBS referred to tertiary care centers, but argued that these studies overestimated the true prevalence of psychosocial disturbance in patients with IBS because psychological factors influence whether patients consult ph”

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Cites

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Research works printed but not linked: 14

  1. Kellow JE, Eckersley GM, Jones MP. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 1991;101:1621-1627.
  2. Mertz H, Tanner G, Morgan V, Pickens D, Price R, Kessler D. Functional MRI detects activation of anterior cingulate and pre- frontal cortex in IBS patients and control subjects during rectosigmoid stimulation (abstr). Gastroenterology 1999;116: A1041.
  3. Ali A, Toner BB. Sexual abuse and self-blame in women with irritable bowel syndrome (abstr). Psychosom Med 1996;58:66.
  4. Mangel AW, Camilleri M, Chey WY, Mayer EA, Northcutt AR, Heath AT, Dukes GE, McSorley D. Alosetron, a 5-HT 3 receptor antagonist, in the treatment of non-constipated female IBS patients (abstr). Am J Gastroenterol 1999;94:2677.
  5. Briejer E, Ghoos E, Eelen J, Schuurkes JAJ. Serotonin 5-HT 4 receptors mediate the R093877-induced changes in contractile patterns in the canine colon (abstr). Gastroenterology 1997; 112:A705.
  6. Bouras EP, Camilleri M, Burton DD, McKinzie S. Selective stim- ulation of colonic transit by the benzofuran 5-HT 4 agonist, pru- calopride, in healthy humans. Gut 1999;44:682-686.
  7. Johanson J, Miner PB, Parkman HP, Wojcik MA, Lambert R, Karcher K, Woods M. Prucalopride improves bowel movement frequency and symptoms in patients with chronic constipation: results of two double-blind, placebo-controlled trials (abstr). Gastroenterology 2000;118:A175.
  8. Miner PB, Nichols T Jr, Silvers DR, Joslyn A, Woods M. The efficacy and safety of prucalopride in patients with chronic constipation (abstr). Gastroenterology 1999;116:A1043.
  9. Tack J, Piessevaux H, Coulie B, Fischler B, De Gucht V, Jans- sens J. A placebo-controlled trial of buspirone, a fundus-relaxing drug, in functional dyspepsia: effect on symptoms and gastric sensory and motor function (abstr). Gastroenterology 1999; 116:A325.
  10. Heefner JD, Wilder RM, Wilson JD. Irritable colon and depres- sion. Psychosomatics 1978;19:540 -547.
  11. Greenbaum DS, Mayle JE, Vanegeren LE, Jerome JA, Mayor JW, Greenbaum RB, Matson RW, Stein GE, Dean HA, Halvorsen NA, Rosen LW. The effects of desipramine on IBS compared with atropine and placebo. Dig Dis Sci 1987;32:257-266.
  12. Holroyd KA, O'Donnell FJ, Stensland J, Lipchik GL, Cordingley GE, Carlson BW. Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination. JAMA 2001;285:2208 -2215.
  13. Fukudo S, Suzuki J. Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on IBS. Tohoku J Exp Med 1987;151:373-385.
  14. Colgan S, Creed FH, Klass SH. Psychiatric disorder and abnor- mal illness behaviour in patients with upper abdominal pain. Psychol Med 1988;18:887-892.

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Authors
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E.
Affiliations
University of North Carolina at Chapel Hill (US)
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2002-12
Volume
123
Issue
6
Pages
2108-2131
ISSN
0016-5085 (ISSN-L)
OpenAlex
W2130505437
Cited by
1,384
References
279
Citations by year
2026: 11 · 2025: 24 · 2024: 34 · 2023: 26 · 2022: 26 · 2021: 43 · 2020: 47 · 2019: 30 · 2018: 49 · 2017: 51 · 2016: 65 · 2015: 62 · 2014: 80 · 2013: 72 · 2012: 73
FWCI
10.16
Type
journal article
Language
en
Open access
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Health Professions › Pharmacy › Infant Health and Development
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
irritable bowel syndrome, functional gastrointestinal disorders, abdominal pain, defecation disorders, health-related quality of life, psychosocial factors, central nervous system, health care costs
MeSH terms
Colonic Diseases, Functional, Drug Therapy, Gastroenterology, Gastrointestinal Motility, Humans, Psychology, Psychotherapy, Psychotropic Drugs, Societies, Medical, United States, Prevalence

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