The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Pathophysiology of asthma
Open accessAbstract
1 Our understanding of asthma and its therapy has changed markedly over the last few years, particularly with the application of molecular and cell biology and the discovery of new and more specific pharmacological tools. 2 Many inflammatory cells participate in the inflammatory process in asthma and mediate a complex mixture of mediators. Cytokines are of particular importance as mediators of chronic inflammation and the means by which cytokines amplify and perpetuate the inflammatory process is now emerging. Airway epithelial cells may be a particularly important source of cytokines and other mediators, such as nitric oxide and endothelin, and may be a major target cell for inhaled steroids, which are the most effective therapy for asthma currently available. 3 The inflammatory process in asthma results not only in bronchoconstriction, but also plasma exudation, the activation of neural mechanisms, mucus secretion. The chronic inflammation may lead to structural changes, including an increase in airway smooth muscle and fibrosis, that are essentially irreversible. There is increasing evidence that transcription factors, such as NF‐κB, play a pivotal role in the expression of inflammatory genes in asthma and may be the major molecular target for glucocorticoids.
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Cites
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
Lipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453
Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans
Gustafsson, L. E., Leone, A. M., Persson, M. G., Wiklund, N. P., & Moncada, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91268-h · Cited by 964
IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma
Shimbara, A., Christodoulopoulos, P., Soussi-Gounni, A., Olivenstein, R., Nakamura, Y., Levitt, R. C., Nicolaides, N. C., Holroyd, K. J., Tsicopoulos, A., Lafitte, J.-J., et al. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(00)90185-4 · Cited by 281
Cited by
Diagnosing Asthma: Comparisons between Exhaled Nitric Oxide Measurements and Conventional Tests
Smith, A. D., Cowan, J. O., Filsell, S., McLachlan, C., Monti-Sheehan, G., Jackson, P., & Taylor, D. R. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200310-1376oc · Cited by 469
Saleh, D., Ernst, P., Lim, S., Barnes, P. J., & Giaid, A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.11.929 · Cited by 437
Self-citationNew insights into the role of cytokines in asthma
Renauld, J.-C. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.8.577 · Cited by 384
Lee, C. G., Cho, S. J., Kang, M. J., Chapoval, S. P., Lee, P. J., Noble, P. W., Yehualaeshet, T., Lu, B., Flavell, R. A., Milbrandt, J., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040104 · Cited by 369
Liu, H., Wang, J., Zhou, W., Wang, Y., & Yang, L. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.02.004 · Cited by 326
Metadata
- Authors
- BARNES, P. J.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 42
- Issue
- 1
- Pages
- 3-10
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W2163635139
- Cited by
- 270
- References
- 4
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- BARNES, P. J. (1996). Pathophysiology of asthma. British Journal of Clinical Pharmacology. https://doi.org/10.1046/j.1365-2125.1996.03721.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
