The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Age‐related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications
Open accessAbstract
Advancing age is characterized by impairment in the function of the many regulatory processes that provide functional integration between cells and organs. Therefore, there may be a failure to maintain homeostasis under conditions of physiological stress. The reduced homeostatic ability affects different regulatory systems in different subjects, thus explaining at least partly the increased interindividual variability occurring as people get older. Important pharmacokinetic and pharmacodynamic changes occur with advancing age. Pharmacokinetic changes include a reduction in renal and hepatic clearance and an increase in volume of distribution of lipid soluble drugs (hence prolongation of elimination half‐life) whereas pharmacodynamic changes involve altered (usually increased) sensitivity to several classes of drugs such as anticoagulants, cardiovascular and psychotropic drugs. This review focuses on the main age‐related physiological changes affecting different organ systems and their implications for pharmacokinetics and pharmacodynamics of drugs.
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Cites
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Sensitivity to triazolam in the elderly
Greenblatt, D. J., Harmatz, J. S., Shapiro, L., Engelhardt, N., Gouthro, T. A., & Shader, R. I. (1991) · New England Journal of Medicine · doi:10.1056/nejm199106133242403 · Cited by 258
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Cited by
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473
Gallagher, P., & O'Mahony, D. (2008) · Age and Ageing · doi:10.1093/ageing/afn197 · Cited by 697
Adverse drug reactions in special populations – the elderly
Davies, E. A., & O'Mahony, M. S. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12596 · Cited by 604
Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences
Pazan, F., & Wehling, M. (2021) · European Geriatric Medicine · doi:10.1007/s41999-021-00479-3 · Cited by 542
Predicting risk of adverse drug reactions in older adults
Lavan, A. H., & Gallagher, P. (2016) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098615615472 · Cited by 455
Metadata
- Authors
- Mangoni, A. A., & Jackson, S. H. D.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2003-12-16
- Volume
- 57
- Issue
- 1
- Pages
- 6-14
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W2149485684
- Cited by
- 1,874
- References
- 5
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- green
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