The DOI matches its Crossref record.
Hepatocellular carcinoma in the thalassaemia syndromes
Abstract
Summary: Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty‐two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 ± 11 years and the mean serum ferritin was 1764 ± 1448 μ g/l. Eighty‐six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.
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Citations
Cited by
Cao, A., & Galanello, R. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181cd68ed · Cited by 722
Survival and Complications in Thalassemia
BORGNA‐PIGNATTI, C., CAPPELLINI, M. D., DE STEFANO, P., DEL VECCHIO, G. C., FORNI, G. L., GAMBERINI, M. R., GHILARDI, R., ORIGA, R., PIGA, A., ROMEO, M. A., et al. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1345.006 · Cited by 426
Self-citationIron, hemochromatosis, and hepatocellular carcinoma
Kowdley, K. V. (2004) · Gastroenterology · doi:10.1016/j.gastro.2004.09.019 · Cited by 391
Vento, S., Cainelli, F., & Cesario, F. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70437-6 · Cited by 211
The Pathophysiology of Transfusional Iron Overload
Porter, J. B., & Garbowski, M. (2014) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2014.04.003 · Cited by 120
Metadata
- Authors
- Borgna‐Pignatti, C., Vergine, G., Lombardo, T., Cappellini, M. D., Cianciulli, P., Maggio, A., Renda, D., Lai, M. E., Mandas, A., Forni, G., Piga, A., & Bisconte, M. G.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2003-12-11
- Volume
- 124
- Issue
- 1
- Pages
- 114-117
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2088277031
- Cited by
- 174
- References
- 0
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Borgna‐Pignatti, C., Vergine, G., Lombardo, T., Cappellini, M. D., Cianciulli, P., Maggio, A., Renda, D., Lai, M. E., Mandas, A., Forni, G., Piga, A., & Bisconte, M. G. (2004). Hepatocellular carcinoma in the thalassaemia syndromes. British Journal of Haematology. https://doi.org/10.1046/j.1365-2141.2003.04732.x
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