The Pathophysiology of Transfusional Iron Overload
Open accessAbstract
The pathophysiologic consequences of transfusional iron overload (TIO) as well as the benefits of iron chelation therapy are best described in thalassemia major, although TIO is increasingly seen in other clinical settings. These consequences broadly reflect the levels and distribution of excess storage iron in the heart, endocrine tissues, and liver. TIO also increases the risk of infection, due to increased availability of labile iron to microorganisms. The authors suggest that extrahepatic iron distribution, and hence toxicity, is influenced by balance between generation of nontransferrin-bound iron from red cell catabolism and the utilization of transferrin iron by the erythron.
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Patients with transfusional iron overload are at increased risk of infections.
“Patients with transfusional iron overload are also at increased risk of infections.8”
From Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron (2017) · cites this paper as [8]
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- Authors
- Porter, J. B., & Garbowski, M.
- Affiliations
- University College London (GB)
- Corresponding author
- Porter, John B.
- Venue
- Hematology/Oncology Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 28
- Issue
- 4
- Pages
- 683-701
- ISSN
- 0889-8588 (ISSN-L)
- OpenAlex
- W2147209510
- Cited by
- 120
- References
- 7
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 16 · 2016: 17 · 2015: 8 · 2014: 1
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Hematology/Oncology Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Keywords
- transfusional iron overload, thalassemia major, iron chelation therapy, cardiac iron, liver iron, infection risk, labile iron, non-transferrin-bound iron, erythron
- MeSH terms
- Anemia, Sickle Cell, Humans, Iron, beta-Thalassemia, Iron Overload, Transfusion Reaction
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