The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Survival and Complications in Thalassemia
Abstract
A bstract: The life expectancy of patients with thalassemia major has significantly increased in recent years, as reported by several groups in different countries. However, complications are still frequent and affect the patients' quality of life. In a recent study from the United Kingdom, it was found that 50% of the patients had died before age 35. At that age, 65% of the patients from an Italian long‐term study were still alive. Heart disease is responsible for more than half of the deaths. The prevalence of complications in Italian patients born after 1970 includes heart failure in 7%, hypogonadism in 55%, hypothyroidism in 11%, and diabetes in 6%. Similar data were reported in patients from the United States. In the Italian study, lower ferritin levels were associated with a lower probability of experiencing heart failure and with prolonged survival. Osteoporosis and osteopenia are common and affect virtually all patients. Hepatitis C virus antibodies are present in 85% of multitransfused Italian patients, 23% of patients in the United Kingdom, 35% in the United States, 34% in France, and 21% in India. Hepatocellular carcinoma can complicate the course of hepatitis. A survey of Italian centers has identified 23 such cases in patients with a thalassemia syndrome. In conclusion, rates of survival and complication‐free survival continue to improve, due to better treatment strategies. New complications are appearing in long‐term survivors. Iron overload of the heart remains the main cause of morbidity and mortality.
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Cites
Borgna‐Pignatti, C., Rugolotto, S., Stefano, P. D., Zhao, H., Cappellini, M. D., Vecchio, G. C. D., Romeo, M. A., Forni, G. L., Gamberini, M. R., Ghilardi, R., et al. (2004) · PubMed · Cited by 1,119
Self-citationSurvival in β-thalassaemia major in the UK: data from the UK Thalassaemia Register
Modell, B., Khan, M., & Darlison, M. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02357-6 · Cited by 583
Brahams, D. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90821-x · Cited by 533
Anderson, L. J., Wonke, B., Prescott, E., Holden, S., Malcolm Walker, J., & Pennell, D. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09740-4 · Cited by 430
MARROW TRANSPLANTATION FOR THALASSAEMIA
Donnall Thomas, E., Sanders, J. E., Buckner, C. D., Papayannopoulou, T., Borgna-Pignatti, C., De Stefano, P., Clift, R., Sullivan, K., & Storb, R. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90319-1 · Cited by 340
Self-citationCappellini, M. D., Robbiolo, L., Bottasso, B. M., Coppola, R., Fiorelli, G., & Mannucci, A. P. M. (2000) · British Journal of Haematology · doi:10.1111/j.1365-2141.2000.02376.x · Cited by 297
Self-citationClinical Indications for Cardiovascular Magnetic Resonance (CMR): Consensus Panel Report #
Pennell, D., Sechtem, U., Higgins, C., Manning, W., Pohost, G., Rademakers, F., van Rossum, A., Shaw, L., & Kent Yucel, E. (2004) · Journal of Cardiovascular Magnetic Resonance · doi:10.1081/jcmr-200038581 · Cited by 274
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Self-citationThromboembolic Events in Beta Thalassemia Major: An Italian Multicenter Study
Borgna Pignatti, C., Carnelli, V., Caruso, V., Dore, F., De Mattia, D., Di Palma, A., Di Gregorio, F., Romeo, M. A., Longhi, R., Mangiagli, A., et al. (1998) · Acta Haematologica · doi:10.1159/000040814 · Cited by 192
Self-citationHepatocellular carcinoma in the thalassaemia syndromes
Borgna‐Pignatti, C., Vergine, G., Lombardo, T., Cappellini, M. D., Cianciulli, P., Maggio, A., Renda, D., Lai, M. E., Mandas, A., Forni, G., et al. (2004) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04732.x · Cited by 174
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Cited by
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
Gardenghi, S., Ramos, P., Marongiu, M. F., Melchiori, L., Breda, L., Guy, E., Muirhead, K., Rao, N., Roy, C. N., Andrews, N. C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41717 · Cited by 220
Tubman, V. N., Fung, E. B., Vogiatzi, M., Thompson, A. A., Rogers, Z. R., Neufeld, E. J., & Kwiatkowski, J. L. (2015) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000307 · Cited by 68
Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Jones, E., Pasricha, S.-R., Allen, A., Evans, P., Fisher, C. A., Wray, K., Premawardhena, A., Bandara, D., Perera, A., Webster, C., et al. (2015) · Blood · doi:10.1182/blood-2014-10-606491 · Cited by 68
Pattern of complications and burden of disease in patients affected by beta thalassemia major
Bonifazi, F., Conte, R., Baiardi, P., Bonifazi, D., Felisi, M., Giordano, P., Giannuzzi, V., Iacono, A., Padula, R., Pepe, A., et al. (2017) · Current Medical Research and Opinion · doi:10.1080/03007995.2017.1326890 · Cited by 49
Metadata
- Authors
- BORGNA‐PIGNATTI, C., CAPPELLINI, M. D., DE STEFANO, P., DEL VECCHIO, G. C., FORNI, G. L., GAMBERINI, M. R., GHILARDI, R., ORIGA, R., PIGA, A., ROMEO, M. A., ZHAO, H., & CNAAN, A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2005-11
- Volume
- 1054
- Issue
- 1
- Pages
- 40-47
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2168463967
- Cited by
- 426
- References
- 16
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- BORGNA‐PIGNATTI, C., CAPPELLINI, M. D., DE STEFANO, P., DEL VECCHIO, G. C., FORNI, G. L., GAMBERINI, M. R., GHILARDI, R., ORIGA, R., PIGA, A., ROMEO, M. A., ZHAO, H., & CNAAN, A. (2005). Survival and Complications in Thalassemia. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1345.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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