Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study
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Background Specific immunotherapy is the only currently available allergen‐orientated treatment able to modify the natural history of respiratory allergic diseases. Safety and clinical efficacy of this treatment are well documented, but evidence about the ability to reduce new sensitizations is still poor. Objective We report a retrospective study conducted in order to assess the prevention of new sensitizations in monosensitized subjects treated with specific immunotherapy vs. monosensitized patients treated with anti‐allergic drugs. Methods 8396 monosensitized patients with respiratory symptoms were selected according to an open, retrospective design. Group A included 7182 patients submitted to specific immunotherapy (and anti‐allergic drugs when needed) for 4 years and then treated with drugs for at least 3 years. Group B included 1214 patients treated only with drugs for at least 7 years. All patients underwent prick test with a standard panel of allergens and total and specific IgE determination before and after 4 years of treatment and again 3 years later. Results Groups were well balanced. Polysensitized subjects were 23.75% in Group A and 68.03% in Group B after 4 years (P < 0.0001) and 26.95% and 76.77%, respectively, after 7 years (P < 0.0001). Asthmatic subjects were more prone to develop polysensitization in comparison to subjects suffering only from rhinitis (32.14% instead of 27.29% after 4 years, 36.5% instead of 31.33% after 7 years; P < 0.0001). Specific IgE decreased by 24.11% in Group A and increased by 23.87% in Group B (P < 0.0001). Total IgE decreased by 17.53% in Group A and increased by 13.71% in Group B (P < 0.0001). Conclusions Specific immunotherapy was observed retrospectively to reduce new sensitizations in monosensitized subjects suffering from respiratory allergic diseases.
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Allergen immunotherapy is thought to help halt progression of allergic disease, including prevention of new allergic sensitivities and development of asthma.
“AIT is also thought to help halt the progression of allergic disease, including prevention of new allergic sensitivities and the development of asthma.1624,1626,1678,1797,1798,1824-1826”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1626]
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- Authors
- Purello‐D'Ambrosio, F., Gangemi, S., Merendino, R. A., Isola, S., Puccinelli, P., Parmiani, S., & Ricciardi, L.
- Affiliations
- University of Messina (IT)
- ALK-Abelló (Italy) (IT)
- Corresponding author
- Gangemi, S.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2001-08
- Volume
- 31
- Issue
- 8
- Pages
- 1295-1302
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W2085196853
- Cited by
- 281
- References
- 76
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 12 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 17 · 2013: 9 · 2012: 14
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical & Experimental Allergy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- allergen immunotherapy, polysensitization, allergic respiratory diseases, asthma, allergic rhinitis, antiallergic drugs, specific IgE, total IgE, allergen sensitization
- MeSH terms
- Contraindications, Administration, Inhalation, Administration, Oral, Adult, Allergens, Epitopes, Asthma, Desensitization, Immunologic, Drug Administration Schedule, Female, Follow-Up Studies, Histamine H1 Antagonists, Humans, Hypersensitivity, Delayed, Immunoglobulin E, Italy, Male, Retrospective Studies, Rhinitis, Receptors, Adrenergic, beta-2, Anti-Allergic Agents, Adrenergic beta-2 Receptor Agonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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