Immunotherapy in allergic rhinitis and lower airway outcomes
Abstract
Allergic rhinitis and asthma constitute two clinical expressions of a single-condition, respiratory allergy. Allergen immunotherapy (AIT) is a form of treatment specifically aimed at modifying the response to sensitizing allergens. The inherent potential benefit of AIT is the simultaneous treatment of all clinical expressions of respiratory allergy. Current data support the effectiveness of subcutaneous and sublingual immunotherapy in rhinitis. Studies also provide proof for a beneficial effect in allergic asthma. Even more, substantial evidence points to the preventive effect on the progression from rhinitis to asthma. Despite the current knowledge on the basic mechanisms underlying the immunological effect of AIT is vast, the specific mechanisms for the preventive effect of primary sensitization or new sensitizations are poorly understood. This review aimed to provide a critical overview of the current knowledge on the effectiveness of AIT and its potential role in secondary prevention of respiratory allergy progression.
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Allergen-specific immunotherapy improves naso-ocular symptoms, including nasal obstruction, in allergic rhinitis.
“AIT modifies the natural history of the disease, improves naso-ocular symptoms (NO included), and reduces the need for medical treatment.”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [167]
Allergen-specific immunotherapy modifies the natural history of allergic rhinitis.
“AIT modifies the natural history of the disease, improves naso-ocular symptoms (NO included), and reduces the need for medical treatment.”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [167]
Allergen-specific immunotherapy improves quality of life in allergic rhinitis.
“In the long term, it can improve or prevent asthma and conjunctivitis, improve QOL, and prevent the development of new sensitizations to aeroallergens [134,167].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [167]
In the long term, allergen-specific immunotherapy can improve or prevent asthma and conjunctivitis in allergic rhinitis.
“In the long term, it can improve or prevent asthma and conjunctivitis, improve QOL, and prevent the development of new sensitizations to aeroallergens [134,167].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [167]
Allergen-specific immunotherapy reduces the need for medical treatment in allergic rhinitis.
“AIT modifies the natural history of the disease, improves naso-ocular symptoms (NO included), and reduces the need for medical treatment.”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [167]
Allergen-specific immunotherapy prevents the development of new sensitizations to aeroallergens.
“In the long term, it can improve or prevent asthma and conjunctivitis, improve QOL, and prevent the development of new sensitizations to aeroallergens [134,167].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [167]
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Allergen injection immunotherapy for seasonal allergic rhinitis
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Position Paper on Nasal Obstruction: Evaluation and Treatment
SEAIC Rhinoconjunctivitis Committee & SEORL Rhinology, A., Valero, A., Navarro, A., del Cuvillo, A., Alobid, I., Benito, Jr., Colás, C., de los Santos, G., Fernández Liesa, R., García-Lliberós, A., et al. (2018) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0232 · Cited by 76 · see citing works
- Authors
- Cardona, V., Luengo, O., & Labrador-Horrillo, M.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Allergy Section; Department of Internal Medicine; Hospital Vall d'Hebron; Barcelona Spain
- Corresponding author
- Cardona, V.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2016-08-15
- Volume
- 72
- Issue
- 1
- Pages
- 35-42
- ISSN
- 0105-4538 (ISSN-L)
- OpenAlex
- W2491932081
- Cited by
- 50
- References
- 5
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 11
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- allergen immunotherapy, allergic rhinitis, allergic asthma, respiratory allergy, subcutaneous immunotherapy, sublingual immunotherapy, secondary prevention, primary sensitization
- MeSH terms
- Allergens, Asthma, Desensitization, Immunologic, Humans, Immunotherapy, Treatment Outcome, Disease Progression, Rhinitis, Allergic
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