Family history and risk of atopic dermatitis in children up to 4 years
Abstract
Background The aetiology of atopic dermatitis (AD) is presumably multi-factorial, with interactions between genetic and environmental factors. Objective To investigate the relation between atopic family history and development of AD up to 4 years. Methods Using annual questionnaires, we studied the cumulative incidence of AD in 0-4-year-olds in a prospective birth cohort of 4089. Atopic diseases in parents and siblings were recorded at birth. The occurrence of serum immunoglobulin E (IgE) antibodies to inhalant and food allergens was analysed in 2614 4-year-olds, and AD was divided into non-IgE-associated and IgE-associated. Results Of the children without atopic parents, 27.1% developed AD; of those with single or double parental atopic history, 37.9% and 50.0%, respectively, did so. The effects of parental history of eczema and of atopic respiratory disease (ARD) did not differ significantly, nor did those of maternal and paternal history. Parental history of ARD increased the risk significantly more for IgE-associated AD than for non-IgE-associated AD (odds ratio (OR) 2.0; 95% confidence interval (CI) 1.5-2.8 vs. OR 1.3; 95% CI 1.0-1.8), whereas the two forms lacked major differences in the effect of parental eczema. A history of eczema in older siblings was a risk indicator for both forms of AD (OR 2.1; 95% CI 1.4-3.3 vs. OR 1.8; 95% CI 1.2-2.6). Conclusions We found no difference between the effects of maternal and paternal atopic history. Parental eczema was a risk fact…
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About 70% of children with AD are sensitized to one or more antigens.
“About 70% of children with AD are sensitized to one or more antigens.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [8]
Several studies have confirmed an association between food allergies and more severe AD, as well as an association between early and persistent development of AD and food allergies, with greater likelihood of sensitization to milk, eggs, and peanuts.
“Several studies have confirmed an association between food allergies and more severe AD, as well as an association between the early and persistent development of AD and food allergies, observing a greater likelihood of sensitization to common foods such as milk, eggs, and peanuts.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [8]
Early-onset AD is related to the development of food allergies.
“In short, early-onset AD is related to the development of food allergies.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [8]
The child of one allergic parent is two to three times more likely to develop atopy, which increases to three to five times more when both parents are allergic.
“The child of one allergic parent is two to three times more likely to develop atopy, which increases to three to five times more when both parents are allergic.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [8]
Most children with AD have at least one parent with respiratory allergies, skin allergies, or both.
“Most children with AD have at least one parent with respiratory allergies, skin allergies, or both.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [8]
Food allergy worsens AD or increases the risk of comorbidities, including anaphylaxis.
“Conversely, food allergy worsens AD or increases the risk of comorbidities, including anaphylaxis.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [8]
Cited by
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Johansson, S. G. O., Bieber, T., Dahl, R., Friedmann, P. S., Lanier, B. Q., Lockey, R. F., Motala, C., Ortega Martell, J. A., Platts-Mills, T. A. E., Ring, J., et al. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.591 · Cited by 2,391 · see citing works
Jedrychowski, W., Perera, F., Maugeri, U., Mrozek-Budzyn, D., Miller, R. L., Flak, E., Mroz, E., Jacek, R., & Spengler, J. D. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000320376 · Cited by 98 · see citing works
Update on the pathogenesis of atopic dermatitis.
Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66 · see citing works
- Authors
- Böhme, M., Wickman, M., Lennart Nordvall, S., Svartengren, M., & Wahlgren, C. F.
- Affiliations
- Karolinska University Hospital (SE)
- Region Stockholm (SE)
- Karolinska Institutet (SE)
- Corresponding author
- Böhme, M.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2003-09
- Volume
- 33
- Issue
- 9
- Pages
- 1226-1231
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W1971804099
- Cited by
- 102
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 9 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 4 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical & Experimental Allergy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vårdalstiftelsen
- Karolinska Institutet
- Astma- och Allergiförbundet
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- atopic dermatitis, family history (medicine), serum IgE, sibling history, birth cohort
- MeSH terms
- Child, Preschool, Dermatitis, Atopic, Eczema, Family, Female, Humans, Immunoglobulin E, Male, Parents, Prospective Studies, Surveys and Questionnaires, Respiratory Hypersensitivity, Risk Factors, Cohort Studies, Odds Ratio
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