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Psoriasis − epidemiology and clinical spectrum
Abstract
Despite psoriasis being a common skin disease, there are still a number of unanswered questions. One of these is the prevalence of the disease, as there is a lack of specific data, with the majority of studies reporting estimates only. Population based studies are rare and longitudinal observations on changing prevalence rates are lacking. This contrasts with other T-cell mediated autoimmune diseases where the number of those affected is rising. Epidemiological studies revealed that a distinct group of diseases is quite frequently associated with psoriasis, e.g. arthritis, colitis, diabetes and hypertension. In contrast, atopic dermatitis and allergies are less frequently seen compared to normal rates of occurrence. As the psoriatic immune response pattern relates to activated Th-1 cells, psoriasis and atopic dermatitis appear to be mutually exclusive due to the Th-1/Th-2 dichotomy.
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Cited by
Efalizumab for Patients With Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial
Gordon, K. B., Papp, K. A., Hamilton, T. K., Walicke, P. A., Dummer, W., Li, N., Bresnahan, B. W., Menter, A., & for the Efalizumab Study Group (2003) · JAMA · doi:10.1001/jama.290.23.3073 · Cited by 391
Toll-Like Receptor Pathways in Autoimmune Diseases
Chen, J.-Q., Szodoray, P., & Zeher, M. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8473-z · Cited by 315
Goh, C., Finkel, M., Christos, P., & Sinha, A. (2006) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.01676.x · Cited by 261
Should we systematically test patients with clinically isolated syndrome for auto-antibodies?
Negrotto, L., Tur, C., Tintoré, M., Arrambide, G., Sastre-Garriga, J., Río, J., Comabella, M., Nos, C., Galán, I., Vidal-Jordana, A., et al. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515575338 · Cited by 11
Metadata
- Authors
- Christophers, E.
- Venue
- Clinical and Experimental Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-06
- Volume
- 26
- Issue
- 4
- Pages
- 314-320
- ISSN
- 0307-6938 (ISSN-L)
- OpenAlex
- W2106686862
- Cited by
- 972
- References
- 0
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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