Toll-Like Receptor Pathways in Autoimmune Diseases

Pathogen Recognition and Innate Immunity

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Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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Toll-like receptor signalling

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Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

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Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry

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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

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Toll-like receptors in innate immunity

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Matrix metalloproteinases and their inhibitors in connective tissue remodeling

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Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

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Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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A family of cytokine-inducible inhibitors of signalling

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The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

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IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors

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A new protein containing an SH2 domain that inhibits JAK kinases

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Structure and function of a new STAT-induced STAT inhibitor

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Diagnostic criteria for multiple sclerosis

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

Kagan, J. C., Su, T., Horng, T., Chow, A. Y., Akira, S., & Medzhitov, R. M. (2008) · Nature Immunology · doi:10.1038/ni1569 · Cited by 1,256 · see citing works

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6668 · Cited by 1,227 · see citing works

The evolution of vertebrate Toll-like receptors

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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells

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TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

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Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

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Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

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Psoriasis − epidemiology and clinical spectrum

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

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Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

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IRAK: A Kinase Associated with the Interleukin-1 Receptor

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Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Horng, T., Barton, G. M., Flavell, R. A., & Medzhitov, R. M. (2002) · Nature · doi:10.1038/nature01180 · Cited by 809 · see citing works

MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?

Sonkoly, E., Wei, T., Janson, P. C. J., Sääf, A., Lundeberg, L., Tengvall-Linder, M., Norstedt, G., Alenius, H., Homey, B., Scheynius, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000610 · Cited by 754 · see citing works

Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis

Thwaites, R. S., Chamberlain, G., & Sacre, S. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00001 · Cited by 748 · see citing works

Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

Compton, T., Kurt‐Jones, E. A., Boehme, K. W., Belko, J., Latz, E., Golenbock, D. T., & Finberg, R. W. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4588-4596.2003 · Cited by 676 · see citing works

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 652 · see citing works

Tumor necrosis factor receptor-associated factors (TRAFs)

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Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

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Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells

Bhaumik, D., Scott, G. K., Schokrpur, S., Patil, C. K., Campisi, J., & Benz, C. C. (2008) · Oncogene · doi:10.1038/onc.2008.171 · Cited by 621 · see citing works

Toll-like receptors modulate adult hippocampal neurogenesis

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Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines

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Gene expression profile analysis of the rat macrophages infected with Toxoplasma gondii

赵志军, 林茹, 郭雅琪, 钟利, Tao, W., 王姝, 殷国民, & 董辉 (2016) · Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) · doi:10.3969/j.issn · Cited by 562 · see citing works

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

Janssens, S., & Beyaert, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00053-4 · Cited by 559 · see citing works

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

Honda, K., Yanai, H., Mizutani, T., Negishi, H., Shimada, N., Suzuki, N., Ohba, Y., Takaoka, A., Yeh, W., & Taniguchi, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406933101 · Cited by 526 · see citing works

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8

Vollmer, J., Tluk, S., Schmitz, C., Hamm, S., Jurk, M., Forsbach, A., Akira, S., Kelly, K. M., Reeves, W. H., Bauer, S., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051696 · Cited by 515 · see citing works

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

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Hemagglutinin Protein of Wild-Type Measles Virus Activates Toll-Like Receptor 2 Signaling

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The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products

Bowie, A., & O'Neill, L. A. J. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.4.508 · Cited by 495 · see citing works

Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies

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Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

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Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis.

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RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll‐like receptor 3

Brentano, F., Schorr, O., Gay, R. E., Gay, S., & Kyburz, D. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21273 · Cited by 377 · see citing works

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

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TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review

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Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

Sloane, J. A., Batt, C. E., Ma, Y. C., Harris, Z. M., Trapp, B. D., & Vartanian, T. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006496107 · Cited by 362 · see citing works

Overexpression of toll‐like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll‐like receptor expression in early and longstanding arthritis

Ospelt, C., Brentano, F., Rengel, Y., Stańczyk, J., Kolling, C., Tak, P. P., Gay, R. E., Gay, S., & Kyburz, D. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24140 · Cited by 351 · see citing works

The expression of toll‐like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll‐like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells

Roelofs, M. F., Joosten, L. A. B., Abdollahi‐Roodsaz, S., van Lieshout, A. W. T., Sprong, T., van den Hoogen, F. H. J., van den Berg, W. B., & Radstake, T. R. D. J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21278 · Cited by 334 · see citing works

Expression of Toll‐like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin‐12 and interleukin‐18 via interferon‐γ

Radstake, T. R. D. J., Roelofs, M. F., Bastiaansen-Jenniskens, Y. M., Oppers‐Walgreen, B., van Riel, P. L. C. M., Barrera, P., Joosten, L. A. B., & van den Berg, W. B. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20678 · Cited by 331 · see citing works

A macrophage marker, siglec‐1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type i interferons and toll‐like receptor agonists

York, M. R., Nagai, T., Mangini, A. J., Lemaire, R., van Seventer, J. M., & Lafyatis, R. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22382 · Cited by 327 · see citing works

Tissue Inhibitor of Metalloproteinase–1 Messenger Rna Expression Is Enhanced Relative to Interstitial Collagenase Messenger Rna in Experimental Liver Injury and Fibrosis

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Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

Negishi, H., Fujita, Y., Yanai, H., Sakaguchi, S., Ouyang, X., Shinohara, M., Takayanagi, H., Ohba, Y., Taniguchi, T., & Honda, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607181103 · Cited by 310 · see citing works

Leptin increase in multiple sclerosis associates with reduced number of CD4 + CD25 + regulatory T cells

Matarese, G., Carrieri, P. B., Cava, A. L., Perna, F., Sanna, V., Rosa, V. D., Aufiero, D., Fontana, S., & Zappacosta, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408995102 · Cited by 301 · see citing works

Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis

Baker, B. S., Ovigne, J. ‐., Powles, A. V., Corcoran, S., & Fry, L. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05287.x · Cited by 300 · see citing works

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology

Wu, H., & Arron, J. R. (2003) · BioEssays · doi:10.1002/bies.10352 · Cited by 299 · see citing works

Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation

Dolganiuc, A., Oak, S. A., Kodys, K., Golenbock, D. T., Finberg, R. W., Kurt‐Jones, E. A., & Szabó, G. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.067 · Cited by 294 · see citing works

Expression and Regulation of Toll-Like Receptor 2 in Rheumatoid Arthritis Synovium

Seibl, R., Birchler, T., Loeliger, S., Hossle, J. P., Gay, R. E., Saurenmann, T., Michel, B. A., Seger, R. A., Gay, S., & Lauener, R. P. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63918-1 · Cited by 286 · see citing works

SOCS1 and SOCS3 in the control of CNS immunity

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Chemokine Secretion of Rheumatoid Arthritis Synovial Fibroblasts Stimulated by Toll-Like Receptor 2 Ligands

Pierer, M., Rethage, J., Seibl, R., Lauener, R. P., Brentano, F., Wagner, U. G., Häntzschel, H., Michel, B. A., Gay, R. E., Gay, S., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1256 · Cited by 273 · see citing works

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7

Savarese, E., Chae, O.-W., Trowitzsch, S., Weber, G., Kastner, B., Akira, S., Wagner, H., Schmid, R. M., Bauer, S., & Krug, A. (2005) · Blood · doi:10.1182/blood-2005-07-2650 · Cited by 273 · see citing works

Innate and adaptive immunity and the pathophysiology of psoriasis

Gaspari, A. A. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.10.057 · Cited by 238 · see citing works

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

Reynolds, J., Martinez, G., Chung, Y., & Dong, C. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1120585109 · Cited by 237 · see citing works

Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies

Pierangeli, S. S., Vega-Ostertag, M. E., Raschi, E., Liu, X., Romay‐Penabad, Z., Micheli, V. D., Galli, M., Moia, M., Tincani, A., Borghi, M. O., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.065037 · Cited by 218 · see citing works

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

Zhang, X., Jin, J., Peng, X., Ramgolam, V. S., & Markovic‐Plese, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6988 · Cited by 201 · see citing works

Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjögren's syndrome

Spachidou, M. P., Bourazopoulou, E., Maratheftis, C. I., Kapsogeorgou, E., Moutsopoulos, H. Μ., Tzioufas, A. G., & Manoussakis, M. N. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03311.x · Cited by 185 · see citing works

The Toll-Like Receptor Adaptor Proteins MyD88 and Mal/TIRAP Contribute to the Inflammatory and Destructive Processes in a Human Model of Rheumatoid Arthritis

Sacre, S. M., Andreakos, E., Kiriakidis, S., Amjadi, P., Lundberg, A. M., Giddins, G. E. B., Feldmann, M., Brennan, F. M., & Foxwell, B. M. J. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060657 · Cited by 185 · see citing works

Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways

Dennehy, K. M., Willment, J. A., Williams, D. L., & Brown, G. D. (2009) · European Journal of Immunology · doi:10.1002/eji.200838543 · Cited by 176 · see citing works

TGF-α Regulates TLR Expression and Function on Epidermal Keratinocytes

Miller, L. S., Sørensen, O. E., Liu, P. T., Jalian, H. R., Eshtiaghpour, D., Behmanesh, B. E., Chung, W., Starner, T. D., Kim, J. J., Sieling, P. A., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6137 · Cited by 162 · see citing works

Innate Immune-Related Receptors in Normal and Psoriatic Skin

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Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts

Lee, A., Qiao, Y., Grigoriev, G., Chen, J., Park‐Min, K., Park, S. H., Ivashkiv, L. B., & Kalliolias, G. D. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37853 · Cited by 155 · see citing works

Reading the viral signature by Toll-like receptors and other pattern recognition receptors

Mogensen, T. H., & Paludan, S. R. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0620-6 · Cited by 146 · see citing works

Impaired IFN-γ-Dependent Inflammatory Responses in Human Keratinocytes Overexpressing the Suppressor of Cytokine Signaling 1

Federici, M., Giustizieri, M. L., Scarponi, C., Girolomoni, G., & Albanesi, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.434 · Cited by 136 · see citing works

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