Somatic mutation of immunoglobulin VH6 genes in human infants

Ridings, J; Dinan, L; Williams, R; Roberton, D; Zola, H

doi:10.1046/j.1365-2249.1998.00694.x

Cited by 53T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies ResearchImmunodeficiency and Autoimmune Disorders

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Somatic mutation of immunoglobulin VH6 genes in human infants

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Ridings, J, Dinan, L, Williams, R, Roberton, D, Zola, H·2001·Clinical and Experimental Immunology

DOI 10.1046/j.1365-2249.1998.00694.xPMC PMC1905087

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Abstract

SUMMARY: Infants respond to antigen by making antibody that is generally of low affinity for antigen. Somatic hypermutation of immunoglobulin genes, and selection of cells expressing mutations with improved affinity for antigen, are the molecular and cellular processes underlying the maturation of antibody affinity. We have reported previously that neonates and infants up to 2 months of age, including individuals undergoing strong immunological challenge, show very few mutated VH6 sequences, with low mutation frequencies in mutated sequences, and little evidence of selection. We have now examined immunoglobulin genes from healthy infants between 2 and 10 months old for mutation and evidence of selection. In this age group, the proportion of VH6 sequences which are mutated and the mutation frequency in mutated sequences increase with age. There is evidence of selection from 6 months old. These results indicate that the process of affinity maturation, which depends on cognate T–B cell interaction and functional germinal centres, is approaching maturity from 6 months old.

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B cells from neonates and infants aged less than 2 months show decreased somatic hypermutation compared with adults, limiting affinity maturation of antibodies.
“B cells from neonates and infants aged less than 2 months show decreased somatic hypermutation compared with adults, limiting affinity maturation of antibodies [37].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [37]

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Somatic hypermutation of immunoglobulin genes in human neonates
Ridings, J., Nicholson, I., Goldsworthy, W., HASLAM, R., Roberton, D. M., & Zola, H. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.3631264.x · Cited by 51
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Rosa, F. D., & Santoni, A. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200207)32:7 · Cited by 67
Age‐related impaired affinity maturation and differential D‐JH gene usage in human VH6‐expressing B lymphocytes from healthy individuals
van Dijk‐Härd, I., Söderström, I., Feld, S., Holmberg, D., & Lundkvist, I. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270613 · Cited by 50
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Authors: Ridings, J., Dinan, L., Williams, R., Roberton, D., & Zola, H.
Affiliations: The University of Adelaide (AU)
Flinders University (AU)
Corresponding author: Zola, H
ORCID: Williams, R
Zola, H
Venue: Clinical and Experimental Immunology
Publisher: Oxford University Press (OUP)
Published: 1998-10
Volume: 114
Issue: 1
Pages: 33-39
ISSN: 0009-9104 (ISSN-L)
1365-2249
DOI: 10.1046/j.1365-2249.1998.00694.x
PMC: PMC1905087
OpenAlex: W2032014294
Cited by: 53
References: 26
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 2
FWCI: 0.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical & Experimental Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords: somatic hypermutation, immunoglobulin variable heavy chain, affinity maturation, infants, mutation frequency, germinal center, T cell-B cell interaction
MeSH terms: Adult, Humans, Immunoglobulin Variable Region, Immunoglobulin alpha-Chains, Immunoglobulin Heavy Chains, Infant, Mutation, Genetic Variation, Complementarity Determining Regions

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Somatic mutation of immunoglobulin VH6 genes in human infants

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