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Cited by 33Growth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and TreatmentsHypothalamic control of reproductive hormones

Hypothalamic derangement in traumatized patients: growth hormone (GH) and prolactin response to thyrotrophin‐releasing hormone and GH‐releasing hormone

De Marinis, Mancini, Valle, Bianchi, Gentilella, Liberale, Mignani, Pennisi +1 more·1999·Clinical Endocrinology
DOI 10.1046/j.1365-2265.1999.00721.x
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Abstract

Objective To study the impact of severe head injury on both basal pituitary hormone secretion and the response to exogenous synthetic hypothalamic releasing factors (TRH and GHRH) in order to evaluate sequential changes in the central control of hypophyseal secretion in the days following head injury. Design Prospective clinical study Patients 21 comatose male patients with head injuries, each intubated and ventilated, intensively monitored and having no previous endocrine problems. Measurements AND RESULTS The GH and PRL responses to TRH (200 microg iv), and the GH and PRL responses to GHRH (50 microg iv) were evaluated, respectively, on the days 1 and 16 and on days 2, 7and 15 after admission. Daily blood samples were also collected for GH, PRL, TSH, T3 and T4 evaluation. In the basal samples taken on days 2, 7 and 15, IGF-I and cortisol were also determined. Nitrogen balance was assessed daily. On the day 1, TRH increased GH levels from 9.8 +/- 2.2 to 22.4 +/- 6.5 mU/l but failed to induce GH release on day 16. The PRL response to TRH was normal. The GH peak response to GHRH was normal on the day 2 (35.7 +/- 13.9 mU/l), but was increased on days 7 and 15 (68.3 +/- 10.7 mU/l on day 7; 73.8 +/- 9.2 mU/l on day 15, P Conclusions The evaluation of pituitary dynamics in the acute phase of a severe injury demonstrates an alteration of GH and PRL secretion, which correlate with the aminergic and/or peptidergic derangements. Taken together, our data suggest augmented tone of both…

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  • The percentage of patients with hypopituitarism after TBI or SAH varies between 20 and 80%.

    “The percentage of patients with hypopituitarism after TBI or SAH varied between 20 and 80%.”

    From Traumatic Brain Injury and Hypopituitarism (2005) · cites this paper as [16]

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Authors
Marinis, D., Mancini, Valle, Bianchi, Gentilella, Liberale, Mignani, Pennisi, & Corte, D.
Affiliations
Università Cattolica del Sacro Cuore (IT)
Corresponding author
De Marinis
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1999-06
Volume
50
Issue
6
Pages
741-747
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1046/j.1365-2265.1999.00721.x
OpenAlex
W2020080429
Cited by
33
References
41
Citations by year
2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2012: 2
FWCI
1.38
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 937 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
traumatic brain injury, hypothalamic-pituitary dysfunction, growth hormone secretion, prolactin secretion, thyrotropin-releasing hormone, growth hormone-releasing hormone, comatose patients, nitrogen balance, insulin-like growth factor I, cortisol, thyroid function, hypothalamic-pituitary-thyroid axis, hypothalamic-pituitary-adrenal axis
MeSH terms
Accidents, Traffic, Acute Disease, Adolescent, Adult, Craniocerebral Trauma, Humans, Hypothalamus, Male, Middle Aged, Pituitary Gland, Prolactin, Growth Hormone, Growth Hormone-Releasing Hormone, Thyrotropin-Releasing Hormone, Time Factors, Statistics, Nonparametric

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