The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Identifying the links between obesity, insulin resistance and β‐cell function: potential role of adipocyte‐derived cytokines in the pathogenesis of type 2 diabetes
Abstract
A combination of insulin resistance and pancreatic β‐cell dysfunction underlies most cases of type 2 diabetes. While the interplay of these two impairments is believed to be important in the development and progression of type 2 diabetes, the mechanisms involved are unclear. A number of factors have been suggested as possibly linking insulin resistance and β‐cell dysfunction in the pathogenesis of type 2 diabetes mellitus. Pro‐inflammatory cytokines such as tumour necrosis factor‐α (TNF‐α) have deleterious effects on both glucose homeostasis and β‐cell function, and can disrupt insulin signalling pathways in both pancreatic β cells and liver and adipose tissue. The anti‐inflammatory activity of the thiazolidinedione anti‐diabetic agents is potentially beneficial, given the possible role of pro‐inflammatory cytokines in linking insulin resistance with β‐cell dysfunction.
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Cited by
Boden, G., & Shulman, G. I. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.3.x · Cited by 1,300
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Metadata
- Authors
- Greenberg, A. S., & McDaniel, M. L.
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2002-05-16
- Volume
- 32
- Issue
- s3
- Pages
- 24-34
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W2026703925
- Cited by
- 290
- References
- 128
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greenberg, A. S., & McDaniel, M. L. (2002). Identifying the links between obesity, insulin resistance and β‐cell function: potential role of adipocyte‐derived cytokines in the pathogenesis of type 2 diabetes. European Journal of Clinical Investigation. https://doi.org/10.1046/j.1365-2362.32.s3.4.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
