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Ovarian atypical endometriosis: its close association with malignant epithelial tumours
Abstract
The incidence of ovarian atypical endometriosis and its association with malignant epithelial tumours in a consecutive series of cases during the period 1987 to 1995 were studied. Atypical glandular changes were observed in four (1.7%) of 255 ovarian endometriosis cases and one patient with ovarian atypical endometriosis developed subsequent endometrioid carcinoma in the abdominal wall. Fifty-four (24.1%) of the 224 ovarian cancers were associated with ovarian endometriosis; 21 with typical and 33 with atypical endometriosis. Clear cell carcinomas and endometrioid carcinomas were most frequently associated with endometriosis, with 54% (27 of 50 cases) and 41.9% (13 of 31), respectively. Atypical endometriosis was found in 18 clear cell carcinomas, in seven endometrioid carcinomas, in four serous carcinomas, in three mucinous borderline tumours, and in one serous borderline tumour. In 13 cases, the atypical endometriosis was in contiguity with malignant epithelial tumours. We consider that atypical endometriosis possesses a precancerous potential or is most frequently associated with clear cell and endometrioid carcinomas. Close screening of cellular atypia or hyperplasia in ovarian endometriosis and careful long-term follow-up of patients with atypical endometriosis is required.
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“One of the reasons is that 14.7 to 22.8% of ovarian carcinomas coexist with atypical endometriosis [13,14].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [13]
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Cho, K. R., & Shih, I. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092246 · Cited by 694
Role of iron in carcinogenesis: cancer as a ferrotoxic disease
Toyokuni, S. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2008.01001.x · Cited by 552
Malignancy in Endometriosis: Frequency and Comparison of Ovarian and Extraovarian Types
Stern, R. C., Dash, R., Bentley, R. C., Snyder, M. J., Haney, A. F., & Robboy, S. J. (2001) · International Journal of Gynecological Pathology · doi:10.1097/00004347-200104000-00004 · Cited by 403
“The development of a neoplasm, be it epithelial or stromal, from atypical endometriosis, be it atypical epithelial or stromal cells, is well documented (6).”
BackgroundPrecursor lesions of ovarian epithelial malignancy
Feeley, K. M., & Wells, M. L. (2001) · Histopathology · doi:10.1046/j.1365-2559.2001.01042.x · Cited by 351
Metadata
- Authors
- FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., & USHIGOME, S.
- Affiliations
- Jikei University School of Medicine (JP)
- Corresponding author
- FUKUNAGA, M.
- ORCID
- FUKUNAGA, M.
- Venue
- Histopathology
- Publisher
- Wiley
- Published
- 1997-03
- Volume
- 30
- Issue
- 3
- Pages
- 249-255
- ISSN
- 0309-0167 (ISSN-L)
- 1365-2559
- OpenAlex
- W2084264037
- Cited by
- 333
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 19 · 2017: 8 · 2016: 10 · 2015: 17 · 2014: 17 · 2013: 14 · 2012: 22
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Histopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometrioma, endometrioid carcinoma, clear cell carcinoma, ovarian cancer, serous carcinoma, serous borderline tumor, long-term follow-up
- MeSH terms
- Adult, Carcinoma, Endometriosis, Female, Humans, Middle Aged, Ovarian Diseases, Ovarian Neoplasms
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