Cited by 336Endometriosis Research and TreatmentOvarian cancer diagnosis and treatmentEndometrial and Cervical Cancer Treatments

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Ovarian atypical endometriosis: its close association with malignant epithelial tumours

FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., USHIGOME, S.·1997·Histopathology

DOI 10.1046/j.1365-2559.1997.d01-592.x

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Abstract

The incidence of ovarian atypical endometriosis and its association with malignant epithelial tumours in a consecutive series of cases during the period 1987 to 1995 were studied. Atypical glandular changes were observed in four (1.7%) of 255 ovarian endometriosis cases and one patient with ovarian atypical endometriosis developed subsequent endometrioid carcinoma in the abdominal wall. Fifty-four (24.1%) of the 224 ovarian cancers were associated with ovarian endometriosis; 21 with typical and 33 with atypical endometriosis. Clear cell carcinomas and endometrioid carcinomas were most frequently associated with endometriosis, with 54% (27 of 50 cases) and 41.9% (13 of 31), respectively. Atypical endometriosis was found in 18 clear cell carcinomas, in seven endometrioid carcinomas, in four serous carcinomas, in three mucinous borderline tumours, and in one serous borderline tumour. In 13 cases, the atypical endometriosis was in contiguity with malignant epithelial tumours. We consider that atypical endometriosis possesses a precancerous potential or is most frequently associated with clear cell and endometrioid carcinomas. Close screening of cellular atypia or hyperplasia in ovarian endometriosis and careful long-term follow-up of patients with atypical endometriosis is required.

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Background
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Background
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“Though this rate is higher than reported in a literature review by Van Gorp et al(5) (36% CCC, 19% EC), it was similar to (42% EC, 54% CCC) the study reported by Fukunaga et al.(10) We found that the incidence of BAF250a loss by IHC in EaOC (55% in CCC and 33% in EC) was not remarkably different than our previous expe…”
BackgroundResultInfluential
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Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls
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“Gene expression profiling studies suggest that SBT is genetically distinct from high-grade serous cancers (40).”
Influential
The Endometriotic Tumor Microenvironment in Ovarian Cancer
Wendel, J. R. H., Wang, X., & Hawkins, S. M. (2018) · Cancers · doi:10.3390/cancers10080261 · Cited by 51
Endometriosis-associated Ovarian Clear Cell Carcinoma: A Special Entity?
Sun, Y., & Liu, G. (2021) · Journal of Cancer · doi:10.7150/jca.61107 · Cited by 52

Authors: FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., & USHIGOME, S.
Affiliations: Jikei University School of Medicine (JP)
Corresponding author: FUKUNAGA, M.
ORCID: FUKUNAGA, M.
Venue: Histopathology
Publisher: Wiley
Published: 1997-03
Volume: 30
Issue: 3
Pages: 249-255
ISSN: 0309-0167 (ISSN-L)
1365-2559
DOI: 10.1046/j.1365-2559.1997.d01-592.x
OpenAlex: W2084264037
Cited by: 333
References: 0
Citations by year: 2026: 5 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 19 · 2017: 8 · 2016: 10 · 2015: 17 · 2014: 17 · 2013: 14 · 2012: 22
FWCI: 4.72
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2434 d)
Locations: Histopathology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords: endometrioma, endometrioid carcinoma, clear cell carcinoma, ovarian cancer, serous carcinoma, serous borderline tumor, long-term follow-up
MeSH terms: Adult, Carcinoma, Endometriosis, Female, Humans, Middle Aged, Ovarian Diseases, Ovarian Neoplasms

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Ovarian atypical endometriosis: its close association with malignant epithelial tumours

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