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Cited by 363T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians

FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., SANSONI, P.·1996·Immunology
DOI 10.1046/j.1365-2567.1996.d01-689.x
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Abstract

Ageing is associated with complex remodelling in the phenotypic and functional profiles of T lymphocytes. We investigated whether expression of CD28 antigen on T cells is conserved throughout adulthood and ageing in humans. For this purpose we analysed T cells obtained from peripheral blood of 102 healthy people of ages ranging from 20 to 105 years. We found an age‐related increase of CD28 − T cells in percentage and absolute number, predominantly among CD8 + T cells. CD28 − T cells from aged donors analysed by flow cytometry appeared as resting cells (not expressing CD25, CD38, CD69, CD71, DR), bearing markers of cytotoxic activity (CD11b and CD57) and with a phenotype compatible with ‘memory’ cells (up‐regulated CD2 and CD11a; CD62L absent). At the functional level, freshly isolated purified CD28 − CD8 + T cells showed high anti‐CD3 redirected cytotoxic activity against Fc‐bearing P815 cells. The same activity tested on freshly isolated bulk T lymphocytes was significantly augmented with age. We found a positive correlation between age, number of CD8 + CD28 − T cells and anti‐CD3 redirected cytotoxicity by freshly isolated T cells. These data suggest that an activation of unknown nature within the cytotoxic arm of the immune system occurs with age. We speculate that these cytotoxic T lymphocytes (CTL) in vivo may constitute armed effector cells for immediate killing of targets bearing peptides from pathogens of intracellular origin.

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Crossref · 10.1046/j.1365-2567.1996.d01-689.x

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Metadata

Authors
FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P.
Affiliations
  • University of Parma (IT)
  • University of Modena and Reggio Emilia (IT)
Corresponding author
SANSONI, P.
ORCID
FRANCESCHI, C.
Venue
Immunology
Publisher
Wiley
Published
1996-08
Volume
88
Issue
4
Pages
501-507
ISSN
  • 0019-2805 (ISSN-L)
  • 1365-2567
DOI
10.1046/j.1365-2567.1996.d01-689.x
OpenAlex
W2030414136
Cited by
362
References
36
Citations by year
2026: 6 · 2025: 8 · 2024: 13 · 2023: 12 · 2022: 15 · 2021: 13 · 2020: 14 · 2019: 13 · 2018: 15 · 2017: 23 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 9 · 2012: 5
FWCI
4.27
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2646 d)
Locations
  • Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centre National de la Recherche Scientifique
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
CD28-negative T cells, CD8+ T cells, cytotoxic T lymphocytes, aging, centenarians, T cell activation, cytotoxicity, T cell memory phenotype, CD11b, CD57, age-related immune changes
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Cell Separation, Cytotoxicity, Immunologic, Flow Cytometry, Humans, Middle Aged, CD3 Complex, CD28 Antigens, CD8-Positive T-Lymphocytes, Lymphocyte Count

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